Volume 4.43 | Oct 31

Extracellular Matrix News 4.43 October 31, 2013
Extracellular Matrix News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Human iPS Cell-Derived Alveolar Epithelium Repopulates Lung Extracellular Matrix
Researchers generated a relatively homogeneous population of alveolar epithelial type II (AETII) and type I (AETI) cells from human induced pluripotent stem cells (iPSCs) that had phenotypic properties similar to those of mature human AETII and AETI cells. They used these cells to explore whether lung tissue can be regenerated in vitro. [J Clin Invest] Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
The Concave Face of Decorin Mediates Reversible Dimerization and Collagen Binding
Scientists found that mutations on the concave face of decorin abolished collagen binding, regardless of whether the mutant proteins retained the ability to dimerize or not. [J Biol Chem] Abstract | Full Article

Activation of Brain Endothelial Cells by Interleukin-1 Is Regulated by the Extracellular Matrix after Acute Brain Injury
Investigators report that extracellular matrix (ECM) remodeling in the cerebrovasculature critically regulates interleukin (IL)-1-induced endothelial cell activation after cerebral ischaemia. Expression levels of ECM molecules associated with the cerebrovasculature, namely fibronectin and collagen IV, strongly increased in brain blood vessels after middle cerebral artery occlusion (MCAo) in a time-dependent manner, reaching a peak of vascular expression 48 hours after MCAo. [Mol Cell Neurosci] Abstract

Complexation and Sequestration of BMP-2 from an ECM Mimetic Hyaluronan Gel for Improved Bone Formation
Bone morphogenetic protein-2 (BMP-2) is considered a promising adjuvant for the treatment of skeletal non-union and spinal fusion. However, BMP-2 delivery in a conventional collagen scaffold necessitates a high dose to achieve an efficacious outcome. To lower its effective dose, the authors precomplexed BMP-2 with the glycosaminoglycans dermatan sulfate or heparin, prior to loading it into a hyaluronic acid hydrogel. [PLoS One] Abstract

Early Kinetics of Integration of Collagen-Glycosaminoglycan Regenerative Scaffolds in a Diabetic Mouse Model
Collagen-glycosaminoglycan scaffolds, originally designed to treat severe burns, are now commonly used in patients with complex wounds associated with diabetes mellitus. The authors investigated how the thickness of the scaffold would affect cellular integration with the diabetic host and whether this can be accelerated using subatmospheric pressure wound therapy devices. [Plast Reconstr Surg] Abstract

Prostate Transglutaminase (TGase-4, TGaseP) Enhances the Adhesion of Prostate Cancer Cells to Extracellular Matrix, the Potential Role of TGase-Core Domain
The impact of TGase-4 on in vitro cell-matrix adhesion, cell migration, growth and in vivo growth were investigated. TGase-4 markedly increased cell-matrix adhesion and cellular migration, and resulted in a rapid growth of prostate tumors in vivo. [J Transl Med] Full Article

Conditioned Medium as a Strategy for Human Stem Cells Chondrogenic Differentiation
Scientists aimed to achieve chondrogenic differentiation of two different sources of stem cells using conditioned medium, without adding growth factors. They tested both human bone marrow-derived mesenchymal stem cells (hBSMCs) and human Wharton’s jelly-derived stem cells (hWJSCs). Cultures using hWJSCs showed significantly higher GAGs accumulation and expression of cartilage-related genes (aggrecan, Sox9 and collagen type II) when compared to hBMSCs cultures. [J Tissue Eng Regen Med] Abstract

Collagen-Chitosan-Laminin Hydrogels for the Delivery of Insulin-Producing Tissue
Human circulating angiogenic cells and porcine islet cells embedded in collagen-chitosan hydrogels, with and without laminin, were investigated as potential engineered biomaterials for the treatment of type 1 diabetes. Hydrogels were evaluated in vitro for their physical properties and cell compatibility. [J Tissue Eng Regen Med] Abstract

Development of a Rotational Cell-Seeding System for Tubularized Extracellular Matrix (ECM) Scaffolds in Vascular Surgery
In this in vitro study a rotational cell-seeding rig (RCR) was constructed to assess the potential for endothelialization of tubular ECM constructs. Human aortic endothelial cells were cultured onto the luminal surfaces of tubular porcine urinary bladder matrix scaffolds and rotated in the RCR at experimental rotational speeds. [J Biomed Mater Res B Appl Biomater] Abstract

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REVIEWS
The Role of Extracellular Matrix in Corneal Wound Healing
This review focuses on the biological functions of several ECM components, such as osteopontin (OPN), tenascin (TCN), and lumican. The loss of OPN or TCN reduces macrophage invasion and myofibroblast differentiation in the healing stroma and is associated with the suppression of fibrogenic gene expression in response to injury sustained in mice. [Cornea] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.
 
INDUSTRY NEWS
Treena Livingston Arinzeh Receives Innovators Award from NJ Inventors Hall of Fame
Treena Livingston Arinzeh, a professor of biomedical engineering at New Jersey Institute of Technology (NJIT), received an Innovators Award from the New Jersey Inventors Hall of Fame in recognition of her research and inventions utilizing biomaterials and regenerative medicines for orthopedic and neural disorders. [New Jersey Institute of Technology] Press Release

Colorado State University Bioengineers Receive Grant to Help Reconstructed Knees Regrow Soft Tissue
Researchers in the Colorado State University School of Biomedical Engineering are developing a material that can help injured knees regenerate soft tissue after reconstructive surgery. Principal Investigator Tammy Haut Donahue and Co-Investigator Ketul Popat, associate professors in the Mechanical Engineering department at Colorado State University, are part of a three-year, $1.2 million grant in conjunction with collaborators in Ireland and Northern Ireland. [Colorado State University] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 1st Matrix Biology Europe (MBE) Conference
June 21-24, 2014
Rotterdam, Netherlands

Visit our events page to see a complete list of events in the extracellular matrix community.
 
JOB OPPORTUNITIES
NEW Multiple Positions (Wake Forest Institute for Regenerative Medicine)

PhD Position – Extracellular Matrix Research (Nencki Institute of Experimental Biology)

PhD Studentship – Molecular Force Sensors for Extracellular Matrix (Radboud University Nijmegen)

PhD Studentship – Collagen IV and Angiogenesis (University of East Anglia)

Assistant Professor – Department of Cell Biology and Anatomy (Rosalind Franklin University of Medicine and Science)

Postdoctoral Position – Tissue Engineering (Weizmann Institute of Science)

PhD Position – Molecular Cell Biology (Weizmann Institute of Science)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies Inc.)


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