Volume 4.41 | Oct 17

Extracellular Matrix News 4.41 October 17, 2013
Extracellular Matrix News
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Augmentation of Integrin-Mediated Mechanotransduction by Hyaluronic Acid
Investigators showed that hyaluronic acid, a soft polymeric glycosaminoglycan matrix component prominent in embryonic tissue and upregulated during multiple pathologic states, augments or overrides mechanical signaling by some classes of integrins to produce a cellular phenotype otherwise observed only on very rigid substrates. [Biomaterials] Abstract
 Brain Food: NeuroCult SM1 for Long-Term Primary Neuronal Culture
PUBLICATIONS (Ranked by impact factor of the journal)
Extended Interaction Network of Procollagen C-Proteinase Enhancer-1 in the Extracellular Matrix
Scientists searched for additional partners of procollagen C-proteinase enhancer 1 (PCPE-1) in the extracellular matrix, which could provide new insights into its biological roles. They identified seventeen new partners of PCPE-1 by surface plasmon resonance imaging. [Biochem J] Abstract | Full Article

Glycosyltransferases and Glycosaminoglycans in Bleomycin and Transforming Growth Factor-β1-Induced Pulmonary Fibrosis
Researchers investigated the expression and regulation of proteoglycan core protein and key enzymes implicated in synthesis and sulfation of glycosaminoglycans in bleomycin and adenovirus-transforming growth factor-β1-induced lung fibrosis in rats. [Am J Respir Cell Mol Biol] Abstract

Fenofibrate Attenuated Glucose-Induced Mesangial Cells Proliferation and Extracellular Matrix Synthesis via PI3K/AKT and ERK1/2
The effect of fenofibrate on high-glucose induced cell proliferation and extracellular matrix exertion and its mechanisms were investigated in cultured rat mesangial cells by the methylthiazoletetrazolium assay, flow cytometry and western blot. [PLoS One] Full Article

Molecular Properties and Fibril Ultrastructure of Types II and XI Collagens in Cartilage of Mice Expressing Exclusively the α1(IIA) Collagen Isoform
Biochemical analyses showed that type IIA collagen extracted from ki/ki mouse rib cartilage can form homopolymers that are stabilized predominantly by hydroxylysyl pyridinoline cross-links at levels that differed from wild type rib cartilage. The findings indicate that mature type II collagen derived exclusively from type IIA procollagen molecules can form hetero-fibrils with type XI collagen and contribute to cartilage structure and function. [Matrix Biol] Abstract

Crosslinking of Collagen Scaffolds Promotes Blood and Lymphatic Vascular Stability
Although chemical crosslinking has been used to stiffen collagen and protect it against enzymatic degradation in vivo, it remains unclear how crosslinking alters the vascularization of collagen hydrogels. In this study, the authors examined how the crosslinking agents genipin and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide alter vascular stability and function in microfluidic type I collagen gels in vitro. [J Biomed Mater Res A] Abstract

Effects of N-Acetyl-L-Cysteine on Adhesive Strength between Breast Cancer Cell and Extracellular Matrix Proteins after Ionizing Radiation
Investigators evaluated the effect of N-acetyl-l-cysteine, a common reactive oxygen species scavenger, on the adhesive affinity between MDA-MB-231 breast cancer cells and extracellular matrix (ECM) proteins after ionizing radiation. They focused mainly on fibronectin, a representative ECM protein. [Life Sci] Abstract

Hrd1 Participates in the Regulation of Collagen I Synthesis in Renal Fibrosis
Researchers examined the hypothesis that Hrd1 posttranslationally regulates collagen synthesis in renal interstitial fibrogenesis. Unilateral ureteral obstruction induced Hrd1 expression, predominantly in the renal interstitium and tubular epithelium of fibrotic kidneys. [Mol Cell Biochem] Abstract

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The Extostosin Family: Proteins with Many Functions
The mammalian extostosin (EXT) proteins have glycosyltransferase activities relevant for heparan sulfate chain polymerization, however their exact role in this process is still confusing. In this review, the authors summarize current knowledge about the biochemical activities and some proposed functions of the members of the EXT protein family and their roles in human disease. [Matrix Biol] Full Article

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.
Yale Researchers Initiate Clinical Trial Evaluating Halozyme’s Recombinant Hyaluronidase in Artificial Pancreas Study
Halozyme Therapeutics, Inc. announced the first patient has been dosed in a closed loop control (artificial pancreas) clinical study involving Halozyme’s recombinant human hyaluronidase being performed by researchers at Yale School of Medicine in patients with type 1 diabetes. [Halozyme Therapeutics, Inc.]
Press Release

360ip and CCRM Join Forces to Source Best Intellectual Property in Regenerative Medicine
360ip and the Canadian Centre for Commercialization of Regenerative Medicine (CCRM) are signing a collaboration agreement to work together in a variety of areas, including developing a fund to invest in best-in-class regenerative medicine technologies and companies in Asia, Europe and North America. [MarketWire L.P.] Press Release

From our sponsor: Free wallchart from Nature Neuroscience – Neural Stem Cells. Request your copy.
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 6th International Epithelial-Mesenchymal Transition Meeting
November 13-16, 2013
Alicante, Spain

NEW Building The Extracellular Matrix: Molecules, Cells and Evolution
April 7-8, 2014
Bristol, United Kingdom

Visit our events page to see a complete list of events in the extracellular matrix community.
NEW PhD Studentship – Molecular Force Sensors for Extracellular Matrix (Radboud University Nijmegen)

NEW PhD Studentship – Collagen IV and Angiogenesis (University of East Anglia)

PhD Fellowship – Physics & Biochemistry of Cell – Polysaccharide Matrix Interactions (CIC Biomagune)

Assistant Professor – Department of Cell Biology and Anatomy (Rosalind Franklin University of Medicine and Science)

Postdoctoral Position – Pancreatic Cancer Biology and Experimental Therapeutics (Massachusetts General Hospital / Radiation Oncology)

Postdoctoral Position – Tissue Engineering (Weizmann Institute of Science)

PhD Position – Molecular Cell Biology (Weizmann Institute of Science)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Technologist – Cell Culture Media & Matrices (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies Inc.)

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