Volume 4.38 | Sep 26

Extracellular Matrix News 4.38 September 26, 2013
Extracellular Matrix News
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Modulation of Keratocyte Phenotype by Collagen Fibril Nanoarchitecture in Membranes for Corneal Repair
Type I collagen membranes with tailored fibril nanoarchitectures were fabricated through a vitrification processing, which mimicked, to a degree, the collagen maturation process of corneal stromal extracellular matrix in vivo. [Biomaterials] Abstract
Brain Food: NeuroCult SM1 for Long-Term Primary Neuronal Culture. View Data!
PUBLICATIONS (Ranked by impact factor of the journal)
Lutheran/Basal Cell Adhesion Molecule Promotes Tumor Cell Migration by Modulating Integrin-Mediated Cell Attachment to Laminin-511
Investigators showed that the preferential binding of lutheran/basal cell adhesion molecule (Lu/B-CAM) to laminin α5 promotes tumor cell migration. The attachment of Lu/B-CAM-transfectants to laminin-511 was slightly weaker than that of control cells, and this was because Lu/B-CAM disturbed integrin binding to laminin α5. [J Biol Chem] Abstract | Full Article

Bves and NDRG4 Regulate Directional Epicardial Cell Migration through Autocrine Extracellular Matrix Deposition
Studies reveal that Blood vessel epicardial substance/N-myc Downstream Regulated Gene 4 (Bves/NDRG4) interaction is required for trafficking of internalized fibronectin through the “autocrine extracellular matrix deposition” fibronectin recycling pathway. Importantly, the authors demonstrated that Bves/NDRG4-mediated fibronectin recycling is indeed essential for epicardial cell directional movement thus linking these two cell processes. [Mol Biol Cell] Abstract

miR-128 Regulates Non-Myocyte Hyperplasia, Deposition of Extracellular Matrix and Islet1 Expression during Newt Cardiac Regeneration
In-situ hybridization techniques revealed a localized expression pattern for miR-128 in the cardiomyocytes and non-cardiomyocytes in close proximity to the regeneration zone and in vivo knockdown studies revealed a regulatory role for miR-128 in proliferating non-cardiomyocyte populations and extracellular matrix deposition. [Dev Biol] Abstract

A Unique Tool to Selectively Detect the Chondrogenic IIB Form of Human Type II Procollagen Protein
Procollagens IIA/D can be re-expressed by dedifferentiating chondrocytes and in osteoarthritic cartilage. Therefore, investigators aimed to determine which isoform(s) is (are) synthesized in vivo in normal and pathological situations and in vitro, to fully assess the phenotype of cells producing type II collagen protein. [Matrix Biol] Abstract

Adenovirus Conducted Connective Tissue Growth Factor on Extracellular Matrix in Trabecular Meshwork and Its Role on Aqueous Humor Outflow Facility
Scientists detected the effect of adenovirus conducted connective tissue growth factor transfection on either the expression of extracellular matrix components or aqueous humor outflow facility. [Mol Biol Rep] Abstract

Effects of Carbon Nanotubes in a Chitosan/Collagen-Based Composite on Mouse Fibroblast Cell Proliferation
Researchers investigated the in vitro cytocompatibility of carbon nanotubes (CNTs) in a chitosan/collagen-based composite. Mouse fibroblasts were cultured on the surface of a novel material consisting of CNTs in a chitosan/collagen-based composite. Cell adhesion and proliferation were observed, and cell apoptosis was measured. [Cell Mol Neurobiol] Abstract

Structure and Barrier Properties of Human Embryonic Stem Cell Derived Retinal Pigment Epithelial Cells Are Affected by Extracellular Matrix Protein Coating
The authors investigated the role of extracellular matrix (ECM) proteins to the structure and function of human embryonic stem cell derived retinal pigment epithelial (hESC-RPE) cells during their differentiation and maturation from hESCs into RPE cells in adherent differentiation cultures on several human ECM proteins found in native human Bruch’s membrane namely collagen I, collagen IV, laminin, fibronectin, vitronectin, as well as on commercial substrates of xeno-free CELLstartTM and MatrigelTM. [Tissue Eng Part A] Abstract

New TeSR™-E8™ is Here- For Feeder-Free Culture of Human ES Cells and iPS Cells
Cell-Scaffold Interactions in the Bone Tissue Engineering Triad
The success of bone tissue engineering relies on understanding the interplay between progenitor cells, regulatory signals, and the biomaterials/scaffolds used to deliver them – otherwise known as the tissue engineering triad. This review discusses the roles of these fundamental components with a specific focus on the interaction between cell behavior and scaffold structural properties. [Eur Cell Mater] Abstract | Full Article

Collagen XV: Exploring Its Structure and Role within the Tumor Microenvironment
The authors examined the structure of collagen XV, its functional domains, and its involvement in cell-surface receptor-mediated signaling pathways, which provide further insights into its role in the suppression of malignancy. [Mol Cancer Res] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.
Adheron Therapeutics Names New Senior Leadership
Adheron Therapeutics, a biotechnology company that is focused on leveraging pioneering technology that disrupts cell adhesion to treat a variety of diseases, has announced the appointments of Robert Baltera as executive chairman of the board and Hari Kumar as chief executive officer, effective immediately. [PR Newswire Association LLC] Press Release

National Cancer Institute Awards $48.6 Million Grant to MD Anderson
Broad, deep and outstanding research in cancer science, treatment and prevention have earned The University of Texas MD Anderson Cancer Center a $48.6-million, five-year grant from the National Cancer Institute and an “exceptional” ranking, the highest possible, from the National Cancer Institute’s extensive peer-review process. [The University of Texas MD Anderson Cancer Center] Press Release

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NEW Signal Transduction by Engineered Extracellular Matrices
July 6-11, 2014
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Visit our events page to see a complete list of events in the extracellular matrix community.
NEW PhD Fellowship – Physics & Biochemistry of Cell – Polysaccharide Matrix Interactions (CIC Biomagune)

PhD Studentship – Molecular Force Sensors for Measuring Forces in the Extracellular Matrix (Radboud University Nijmegen)

Postdoctoral Position – Development of Uni-Lamellar Scaffolds for Bio-Mineralization in Bone Repair (Fujifilm)

Postdoctoral Position – Electro-Spinning: Scaffolding and Drug Delivery for Regenerative Medicine Applications (Center for Nanomedicine and Tissue Engineering)

PhD Position – Biomaterial Imaging (Uppsala University)

Postdoctoral Position – Tissue Engineering (Weizmann Institute of Science)

PhD Position – Molecular Cell Biology (Weizmann Institute of Science)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Technologist – Mesenchymal Cell Research (STEMCELL Technologies Inc.)

Research Technologist – Cell Culture Media & Matrices (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies Inc.)

Quality Control Analyst – Media (STEMCELL Technologies Inc.)

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