Volume 4.29 | Jul 25

Extracellular Matrix News 4.29 June 25, 2013
Extracellular Matrix News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
The Use of Bioinspired Alterations in the Glycosaminoglycan Content of Collagen-GAG Scaffolds to Regulate Cell Activity
Glycosaminoglycans (GAGs) of increasing sulfation (hyaluronic acid, chondroitin sulfate, heparin) were incorporated into a collagen-GAG scaffold under development for tendon tissue engineering. Manipulating the degree of GAG sulfation significantly impacts sequestration of growth factors from the media. [Biomaterials] Abstract
New TeSR™-E8™ is Here, For Feeder-Free Culture of Human ES Cells and iPS Cells
 
PUBLICATIONS (Ranked by impact factor of the journal)
β1 Integrin Is a Crucial Regulator of Pancreatic β-Cell Expansion
Researchers showed that ablation of the β1 integrin gene in developing pancreatic β-cells reduces their ability to expand during embryonic life, during the first week of postnatal life, and thereafter. [Development] Abstract

Dermatopontin Regulates Fibrin Formation and Its Biological Activity
Scientists examined the role of dermatopontin (DP) on fibrin function. DP interacted with both the fibrin monomer and fibrils, and was incorporated into the fibrils during fibrin formation. [J Invest Dermatol] Abstract

The Small GTPase N-Ras Regulates Extracellular Matrix Synthesis, Proliferation and Migration in Fibroblasts
Researchers investigated some of the mechanisms involved in the development of renal fibrosis, assessing the individual role of N-Ras in basal and transforming growth factor-β1-mediated extracellular matrix synthesis, proliferation, and migration in immortalized N-Ras deficient fibroblasts. [Biochim Biophys Acta] Abstract

ECM-Incorporated Hydrogels Crosslinked via Native Chemical Ligation to Engineer Stem Cell Microenvironments
Limiting the precise study of the biochemical impact of whole molecule extracellular matrix (ECM) proteins on stem cell differentiation is the lack of 3D in vitro models that can accommodate many different types of ECM. Here researchers sought to generate such a system while maintaining consistent mechanical properties and supporting stem cell survival. [Biomacromolecules] Abstract

Surface α-Enolase Promotes Extracellular Matrix Degradation and Tumor Metastasis and Represents a New Therapeutic Target
The authors demonstrated that surface α-enolase promotes extracellular matrix degradation and invasion of cancer cells and that targeting surface α-enolase is a promising approach to suppress tumor metastasis. [PLoS One] Full Article

Extracellular Matrix Composition Significantly Influences Pancreatic Stellate Cell (PSC) Gene Expression Pattern: Role of Transgelin in PSC Function
The authors aimed to compare PSC gene expression after culture on plastic, Matrigel™ and collagen I; validate the gene array data for transgelin, the most highly dysregulated gene in PSCs grown on activating versus non-activating matrices, at mRNA and protein levels; examine the role of transgelin in PSC function; and assess transgelin expression in human chronic pancreatitis sections. [Am J Physiol Gastrointest Liver Physiol] Abstract

Polypropylene Surgical Mesh Coated with Extracellular Matrix Mitigates the Host Foreign Body Response
A method for applying a porcine dermal extracellular matrix hydrogel coating to a polypropylene mesh is described herein with the associated effects upon the host tissue response and biaxial mechanical behavior.[J Biomed Mater Res A] Abstract

A New Method to Determine Rate-Dependent Material Parameters of Corneal Extracellular Matrix
The biomechanical properties of the cornea are largely governed by the composition and structure of the stromal layer which is an extracellular matrix composed of collagen fibrils embedded in a hydrated soft matrix. In the present study, unconfined compression experiments were used to investigate the influence of loading rates on compressive behavior of nineteen porcine corneal specimens. [Ann Biomed Eng] Abstract

Directed Differentiation of Pluripotent Stem Cells - A Cell Stem Cell Poster
 
REVIEWS
The Pathobiology of Collagens in Glioma
The authors provide a comprehensive overview of the nature of collagens found in gliomas and offer insights into the mechanisms by which cancer cells interact with this extracellular matrix via receptors including the integrins, discoidin domain receptors and Endo180. [Mol Cancer Res] Abstract

Extracellular Matrix Microenvironment Contributes Actively to Pulmonary Fibrosis
The authors describe the contribution of an altered, profibrotic extracellular matrix (ECM) microenvironment to pulmonary fibrosis and how it changes cell behavior and actively drives disease progression. [Curr Opin Pulm Med] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.
 
INDUSTRY NEWS
Novozymes Biopharma’s Hyasis Increases In Vitro Drug Release from 10 Minutes to 15 Hours
An investigation undertaken by Novozymes Biopharma DK has shown that when the corticosteroid dexamethasone is formulated in a cross-linked hyaluronic acid hydrogel, the drug’s in vitro release time increases from under 10 minutes to approximately 15 hours. [Novozymes Biopharma DK] Press Release

Organovo and Methuselah Foundation Announce Funding of Bioprinting Research at Research Institutions
Organovo Holdings, Inc. and Methuselah Foundation announced that Methuselah Foundation has initiated a campaign in which it will fund research at major research institutions using Organovo’s proprietary NovoGen Bioprinting technology. [Organovo Holdings Inc.] Press Release

New wallchart from our sponsor: Mesenchymal Stem Cells (A Nature Reviews Molecular Cell Biology collaboration). Request your free copy.
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 2nd International Conference on Tissue Engineering and Regenerative Medicine (ICTERM-2013)
November 15-17, 2013
Rourkela, India

NEW 11th Annual Commercial Translation of Regenerative Medicine
November 25-26, 2013
London, United Kingdom

Visit our events page to see a complete list of events in the extracellular matrix community.
 
JOB OPPORTUNITIES
NEW PhD Position – Biomaterials for Regenerative Medicine (Institute for Bioengineering of Catalonia)

PhD Position – Molecular Cell Biology (Weizmann Institute of Science)

Postdoctoral Fellow – Mechanisms Contributing to Metastases of Breast Cancer Cells (Mount Sinai Medical Center/Icahn School of Medicine at Mount Sinai)

Assistant/Associate Professor Position – Correlative Light and Electron Microscopy (Universite de Montreal)

Director of Cell Processing Facility (S L Collins Associates, Inc.)

PhD Position – 3D Structured Self-Assembled Hydrogels for Tissue Engineering (Delft University of Technology)

Postdoctoral Position – Tissue Engineering (Weizmann Institute of Science)


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