Volume 4.28 | Jul 18

Extracellular Matrix News 4.28 July 18, 2013

Extracellular Matrix News

     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs

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Extracellular Matrix of Secondary Lymphoid Organs Impacts on B-Cell Fate and Survival
Scientists describe a unique extracellular matrix niche in the spleen, the marginal zone (MZ), characterized by the basement membrane glycoproteins, laminin a5 and agrin, that promotes formation of a specialized population of MZ B lymphocytes that respond rapidly to blood-borne antigens. [Proc Natl Acad Sci USA] Abstract

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PUBLICATIONS (Ranked by impact factor of the journal)

Injectable Laminin-Functionalized Hydrogel for Nucleus Pulposus Regeneration
An injectable, laminin-111 functionalized poly(ethylene glycol) (PEG-LM111) hydrogel was developed as a biomaterial carrier for cell delivery to the intervertebral disc (IVD). They evaluated the mechanical properties of the PEG-LM111 hydrogel, and its ability to retain delivered cells in the IVD space. [Biomaterials]
| Press Release

The Anti-Metastatic Activity of Collagenase-2 in Breast Cancer Cells Is Mediated by a Signaling Pathway Involving Decorin and miR-21
Researchers showed that collagenase-2 (Mmp8) expression causes a decrease in miR-21 levels that in turn leads to a reduction in tumor growth and lung metastasis formation by MDA-MB-231 breast cancer cells. By using both in vitro and in vivo models, they demonstrated that the mechanism responsible for these MMP-8 beneficial effects involves cleavage of decorin by MMP-8 and a subsequent reduction of transforming growth factor ß signaling that controls miR-21 levels. [Oncogene] Abstract

Collagen Architecture in Pregnancy-Induced Protection from Breast Cancer
Utilizing tumor cells capable of transitioning from indolent to proliferative/invasive states, investigators demonstrated that mammary extracellular matrix from parous rats (parous matrix) decreases tumor growth and impedes cellular phenotypes associated with tumor cell invasion compared to nulliparous matrix. [J Cell Sci] Abstract

Posttranslational Modifications in Type I Collagen from Different Tissues Extracted from Wild Type and Prolyl 3-Hydroxylase 1 Null Mice
Scientists found that type I collagen extracted from tendon, skin and bone of wild type and prolyl 3-hydroxylase 1 null mice showed distinct patterns of 3-hydroxylation and glycosylation of hydroxylysine residues. The A1 site in the a1-chain of type I collagen is almost completely 3-hydroxylated in every tissue of the wild type mice. [J Biol Chem] Abstract | Full Article

Insulin and IGF1 Modulate Turnover of Polysialylated Neuronal Cell Adhesion Molecule (PSA-NCAM) in a Process Involving Specific Extracellular Matrix Components
Regulation of cell-surface PSA-NCAM is traditionally viewed as a direct consequence of polysialyltransferase activity. Taking advantage of the polysialyltransferase Ca2+-dependent activity, researchers demonstrated in TE671 cells that downregulation of PSA-NCAM synthesis constitutes a necessary but not sufficient condition to reduce cell-surface PSA-NCAM; instead, PSA-NCAM turnover required internalization of the molecule into the cytosol. PSA-NCAM internalization was specifically triggered by collagen in the extracellular matrix and prevented by insulin-like growth factor and insulin. [J Neurochem] Abstract | Press Release

Nonlinear Strain Stiffening Is Not Sufficient to Explain How Far Cells Can Feel on Fibrous Protein Gels
The authors systematically investigated the distance fibroblasts can sense a rigid boundary through fibrous gels by quantifying the spread areas of human lung fibroblasts and 3T3 fibroblasts cultured on sloped collagen and fibrin gels. [Biophys J] Abstract

Extracellular Matrix of Adipogenically Differentiated Mesenchymal Stem Cells Reveals a Network of Collagen Filaments, Mostly Interwoven by Hexagonal Structural Units
Little is known about the structural organization of matrix especially of mesenchymal stem cell-derived adipogenic extracellular matrix (ECM). Here, researchers focused on the composition and architecture of the fat ECM to understand the cellular behavior on functional bases. [Matrix Biol] Abstract

Collagen Morphology and Texture Analysis: From Statistics to Classification
Researchers present an image analysis methodology capable of quantifying morphological changes in tissue collagen fibril organization caused by pathological conditions. [Sci Rep] Abstract

Matrix-Specified Differentiation of Human Decidua Parietalis Placental Stem Cells
Researchers studied the effect of collagen type I on stem cell lineage specification. They altered the properties of collagen type I by incorporating carbon nanotubes (CNT). The collagen-CNT composite material was stiffer with thicker fibers and longer D-period. Human decidua parietalis stem cells were found to differentiate exclusively and rapidly towards neural cells on the collagen-CNT matrix. [Biochem Biophys Res Commun] Abstract

On the Potential of Hydrated Storage for Naturally Derived ECMs and Associated Effects on Mechanical and Cellular Performance
This study evaluated the effects of up to 16 weeks hydrated storage on the mechanical and cellular performance of stented and unstented tubular scaffolds. Investigators aimed to demonstrate the viability, mechanical integrity, and bioactive potential of xenogeneic extracellular matrices (ECMs) as potential off-the-shelf vascular prosthetic devices. [J Biomed Mater Part B] Abstract

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Regulating Tension in Three-Dimensional Culture Environments
The authors describe the role of tension in regulating cell behavior in three-dimensional collagen and fibrin matrices with a focus on the effective use of global boundary conditions to modulate the tension generated by populations of cells acting in concert. [Exp Cell Res] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.




First In-Depth Study of Knee Cartilage Repair Technique Shows Improvement in Patient Outcomes and Regeneration of Knee Cartilage
A natural tissue graft can spur regeneration of cartilage and improve symptoms in patients who have cartilage damage in their knee, according to a study by researchers from Hospital for Special Surgery. [Press release from Hospital for Special Surgery discussing research presented at the American Orthopaedic Society for Sports Medicine (AOSSM), Chicago] Press Release

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Spanish Scientists Successfully Generate ‘Artificial Bones’ from Umbilical Cord Stem Cells
Scientists have patented a new biomaterial that facilitates generating bone tissue-artificial bones in other words-from umbilical cord stem cells. The material, consisting of an activated carbon cloth support for cells that differentiate giving rise to a product that can promote bone growth, has recently been presented at a press conference at the Biomedical Research Centre, Granada. [EurekAlert!] Press Release

ThermoGenesis and TotipotentRx Announce Definitive Merger Agreement
ThermoGenesis Corp. and TotipotentRx Corporation announced that they have entered into a definitive merger agreement. The combined company is expected to become one of the first fully integrated regenerative medicine companies, developing clinically validated, commercially scalable, point-of-care cell therapies for major therapeutic markets, including orthopedic, cardiovascular and neurologic indications. [ThermoGenesis Corp.] Press Release




National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)




NEW The European Society of Gene and Cell Therapy (ESGCT) and Sociedad Española de Terapia Génica y Celular (SETGyC) Collaborative Congress 2013
October 25-28, 2013
Madrid, Spain

Visit our events page to see a complete list of events in the extracellular matrix community.




NEW PhD Position – Molecular Cell Biology (Weizmann Institute of Science)

NEW Postdoctoral Fellow – Mechanisms Contributing to Metastases of Breast Cancer Cells (Mount Sinai Medical Center/Icahn School of Medicine at Mount Sinai)

NEW Assistant/Associate Professor Position – Correlative Light and Electron Microscopy (Universite de Montreal)

Director of Cell Processing Facility (S L Collins Associates, Inc.)

PhD Position – 3D Structured Self-Assembled Hydrogels for Tissue Engineering (Delft University of Technology)

Postdoctoral Position – Tissue Engineering (Weizmann Institute of Science)

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