Volume 4.20 | May 23

Extracellular Matrix News 4.20 May 23, 2013
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Cochlin Produced by Follicular Dendritic Cells Promotes Antibacterial Innate Immunity
Investigators report that cochlin is specifically expressed by follicular dendritic cells and selectively localized in the fine extracellular network of conduits in the spleen and lymph nodes. During inflammation, cochlin was cleaved by aggrecanases and secreted into blood circulation. In models of lung infection with Pseudomonas aeruginosa and Staphylococcus aureus, Coch-/- mice showed reduced survival linked to defects in local cytokine production, recruitment of immune effector cells, and bacterial clearance. By producing cochlin, follicular dendritic cells thus contribute to the innate immune response in defense against bacteria. [Immunity] Full Article | Graphical Abstract

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Extracellular Matrix Metalloproteinase Inducer Shows Active Perivascular Cuffs in Multiple Sclerosis
Scientists investigated whether the expression of extracellular matrix metalloproteinase inducer varies with the temporal evolution of lesions in murine experimental autoimmune encephalomyelitis, whether it was uniformly upregulated across multiple sclerosis specimens, and whether it was a feature of inflammatory perivascular cuffs in multiple sclerosis lesions. [Brain] Abstract

Combination Therapy of Human Adipose-Derived Stem Cells and Basic Fibroblast Growth Factor Hydrogel in Muscle Regeneration
Investigators determined whether combination therapy using human adipose-derived stem cells and basic fibroblast growth factor incorporated into hydrogel could enhance muscle regeneration in a muscle laceration animal model. [Biomaterials] Abstract

Interleukin-13 Induces Collagen Type-1 Expression through Matrix Metalloproteinase-2 and Transforming Growth Factor-β1 in Airway Fibroblasts in Asthma
Investigators hypothesized that interleukin-13 stimulates collagen type-1 production by the airway fibroblast in a matrix metalloproteinase- and transforming growth factor-β1-dependent manner in human asthma as compared to healthy controls. [Eur Respir J] Abstract

Molecular Composition of Extracellular Matrix in the Vestibular Nuclei of the Rat
By using histochemical and immunohistochemical methods, scientists provide a detailed map of the distribution of extracellular matrix (ECM) molecules in the vestibular nuclear complex (VNC) of the rat. They observed common characteristics of the ECM staining pattern in the VNC and a number of differences among the individual vestibular nuclei and their subdivisions. [Brain Struct Funct] Abstract

Texas Three-Step Decellularization Protocol: Looking at the Cardiac Extracellular Matrix
Researchers describe testing of a series of protocols that enabled us to develop a novel optimized strategy for the enrichment and solubilization of extracellular matrix (ECM) components. Following tissue decellularization, they used acid extraction and enzymatic deglycosylation to facilitate re-solubilization. The end result is the generation of three fractions for each sample: soluble components, cellular components, and an insoluble ECM fraction. [J Proteomics] Abstract

Human Breast Cancer-Associated Fibroblasts Enhance Cancer Cell Proliferation through Increased TGF-α Cleavage by ADAM17
The authors demonstrated increased expression of ADAM17 protein in cancer-associated fibroblasts extracted from human breast carcinomas compared with donor-matched normal fibroblasts, and TGF-α secretion positively correlates with ADAM17 expression in these cells. [Cancer Lett] Abstract

Age-Related Bone Deterioration Is Diminished by Disrupted Collagen Sensing in Integrin α2β1 Deficient Mice
Scientists showed for the first time that integrin α2 deficiency is linked to collagen type I expression in bone. Investigating the femurs of wild type and integrin α2β1 deficient mice, they found that loss of integrin α2 results in altered bone properties. [Bone] Abstract

Human Amniotic Fluid- and Dental Pulp-Derived Stem Cells Seeded into Collagen Scaffold Repair Critical Size Bone Defects Promoting Vascularization
Researchers evaluated potential human stem cells, such as dental pulp stem cells and amniotic fluid stem cells, combined with collagen scaffold, to reconstruct critical size cranial bone defects in animal model. [Stem Cell Res Ther] Abstract | Full Article

Novel Biomimetic Hydroxyapatite/Alginate Nanocomposite Fibrous Scaffolds for Bone Tissue Regeneration
Hydroxyapatite/alginate nanocomposite fibrous scaffolds were fabricated via electrospinning and a novel in situ synthesis of hydroxyapatite that mimics mineralized collagen fibrils in bone tissue. [J Mater Sci Mater Med] Abstract

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Membrane-Type Matrix Metalloproteinases: Key Mediators of Leukocyte Function
This review summarizes the current knowledge on the expression of membrane-type matrix metalloproteinases in leukocytes and their contribution to the immune responses and to pathological conditions. [J Leukoc Biol] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.


Baxter Receives Marketing Authorization for HyQvia in European Union
Baxter International Inc. and Halozyme Therapeutics, Inc., announced that the European Commission has granted Baxter marketing authorization in all European Union Member States for the use of HyQvia as replacement therapy for adult patients with primary and secondary immunodeficiencies.  The product is a combination of human normal immunoglobulin (IGSC, 10%) and recombinant human hyaluronidase, which facilitates the dispersion and absorption of the IGSC. [Baxter International Inc.] Press Release

Halozyme Therapeutics Names David A. Ramsay Chief Financial Officer
Halozyme Therapeutics, Inc. announced the appointment of David A. Ramsay as Chief Financial Officer.  Mr. Ramsay was most recently Vice President, Corporate Development at Halozyme. [Halozyme Therapeutics, Inc.] Press Release

AxoGen, Inc. Receives Grant in Partnership with Vanderbilt University from U.S. Department of Defense
AxoGen, Inc. announced that the Company and Vanderbilt University have been awarded a shared $1.1 million grant, for which AxoGen’s portion is approximately 35%, from the Congressional Directed Medical Research Programs administrated by the U.S. Department of Defense to support the development and expansion of nerve repair technologies. [AxoGen, Inc.] Press Release

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Center for Biologics Evaluation and Research (United States)
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Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


NEW 9th Pan Pacific Connective Tissue Societies Symposium: The Extracellular Matrix Niche
November 24-27, 2013
Hong Kong, China

Visit our events page to see a complete list of events in the extracellular matrix community.


NEW PhD Studentship – ECM Components in Human Genetic Disorders (McGill University)

Postdoctoral Studentship – Molecular Biomechanics of α-Actin Remodeling (Eindhoven University of Technology)

Postdoctoral Fellow – Stem Cell and Cancer Biology (Johns Hopkins University School of Medicine)

PhD Position – Scaffolds Functionalization (FORTH-Ultrafast Laser Micro/Nano Processing)

Price Gilbert, Jr. Chair in Regenerative Engineering and Medicine (Georgia Institute of Technology)

Postdoctoral Position – Extracellular Matrix + Developmental Biology (Purdue University)

Postdoctoral Position – Tissue Engineering (Weizmann Institute of Science)

Postdoctoral Fellow – Extracellular Microenvironment in Blood Vessel Morphogenesis (Thomas Jefferson University)

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