Volume 4.04 | Jan 31

Extracellular Matrix News 4.04 January 31, 2013
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LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis
Scientists demonstrated a critical role for lysyl oxidase (LOX) in establishing a milieu within fibrosing tissues that is favorable to growth of metastatic tumor cells. They showed that LOX-dependent collagen crosslinking is involved in creating a growth-permissive fibrotic microenvironment capable of supporting metastatic growth by enhancing tumor cell persistence and survival. [Cancer Res] Abstract

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Ideal Scaffolds that Represent Native Extracellular Matrix (ECM) Properties of Musculofascial Tissues Have Great Importance in Musculofascial Tissue
Investigators developed a decellularization protocol for processing pig composite musculofascial tissues. Decellularized muscle and decellularized fascia, which are two important components of decellularized musculofascial ECM, were comprehensively characterized. [Biomaterials] Abstract

Leptin-Mediated Regulation of MT1-MMP Localization Is Kinesin Family Member 1B-Dependent and Enhances Gastric Cancer Cell Invasion
The authors characterized the influence of leptin on the generation and surface localization of membrane type 1-matrix metalloproteinase (MT1-MMP) in gastric cancer (GC) and elucidated its molecular mechanisms. Results revealed that leptin promoted GC cell invasion in vitro by upregulating MT1-MMP expression. [Carcinogenesis] Abstract

Hyaluronic Acid Click Hydrogels Emulate the Extracellular Matrix
This study demonstrates the versatility of hyaluronic acid based hydrogels with independent control over hydrogel properties such as mechanics, architecture, and spatial distribution of biological factors. Hydrogels were prepared by reacting furan-modified hyaluronic acid with bis-maleimide-poly(ethylene glycol) in a Diels-Alder click reaction. [Langmuir] Abstract

Extracellular Matrix Protein Lumican Promotes Clearance and Resolution of Pseudomonas aeruginosa Keratitis in a Mouse Model
Lumican is a major component of the cornea, yet its role in counteracting live bacteria in the cornea remains poorly understood. Scientists investigated Pseudomonas aeruginosa infections of the cornea in lumican deficient mice. [PLoS One] Full Article

The Impact of Compact Layer in Biphasic Scaffold on Osteochondral Tissue Engineering
A novel biphasic scaffold composed of a bony phase, chondral phase and compact layer was developed. The compact layer-free biphasic scaffold taken as control group was also fabricated. Researchers evaluated the impact of the compact layer in the biphasic scaffold. [PLoS One] Full Article

Comparison of In Vivo Adipogenic Capabilities of Two Different Extracellular Matrix Microparticle Scaffolds
Adipose tissue extract microparticle scaffolds from human adipose tissue and small intestine submucosa microparticle scaffolds from porcine jejunum were prepared. Their effects on the adipogenic capabilities of human adipose-derived stem cells were compared in vivo. [Plast Reconstr Surg] Abstract

Stage Specific Effect of Leptin on the Expressions of Estrogen Receptor and Extracellular Matrix in a Model of Chondrocyte Differentiation
Researchers investigated the effect of leptin on the expression of estrogen receptors and extracellular matrix in ATDC5 cells, an in vitro model of endochondral ossification. [Cytokine] Abstract

Collagen/Beta1 Integrin Interaction Is Required for Embryoid Body Formation during Cardiogenesis from Murine Induced Pluripotent Stem Cells
The role of extracellular matrix/integrin interaction in the formation of embryoid bodies (EBs) during cardiogenesis from murine induced pluripotent stem cells (miPSCs) remains unclear. Here, collagen type I and beta1 integrin were expressed and upregulated synergistically during the formation of miPSC-derived EBs, with a peak expression at day three of differentiation. [BMC Cell Biol] Abstract | Full Article

In Vitro Evaluation of the Interactions between Human Corneal Endothelial Cells and Extracellular Matrix Proteins
To evaluate the interaction of human corneal endothelial cells (CECs) with extracellular matrix (ECM) proteins, cells were seeded on ECM-coated tissue culture dishes, including collagen type I, collagen type IV, fibronectin (FN), FN coating mix and laminin. Cell adhesion and proliferation of human CECs on each substratum and expression of CEC markers were studied. [Biomed Mater] Full Article

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Spheroid Culture as a Tool for Creating 3D Complex Tissues
The authors review new possibilities that combine the strengths of spheroid culture with new microenvironment fabrication methods that allow for the creation of large numbers of highly reproducible, complex tissues. [Trends Biotechnol] Abstract

Current Approaches to Electrospun Nanofibers for Tissue Engineering
The authors discuss current approaches to the development of modular electrospun fibers as scaffolds for tissue engineering. Their chemical and physical characteristics can be tuned for the regeneration of specific target tissues by co-spinning of multiple materials and by post-modification of the surface of electrospun fibers. [Biomed Mater] Abstract | Full Article

Hanson Wade REGEN 2013 - Clinical Trials & Reimbursement Meeting


Clinical Trial Finds CorMatrix ECM® Technology Does Not Increase Incidence of Postoperative Cardiac Tamponade or Graft Closure
CorMatrix® Cardiovascular, Inc. announced preliminary results of its New Onset Post-Operative Atrial Fibrillation Clinical Trial. The randomized, prospective trial evaluated the use of CorMatrix ECM® to close the pericardium of patients undergoing first-time coronary artery bypass grafting at 15 U.S. clinical sites by examining post-operative clinical outcomes and the incidence of selected complications. [Business Wire] Press Release

Salk Institute Awarded Historic $42 Million Grant From the Helmsley Charitable Trust
The Salk Institute for Biological Studies has received a $42 million gift-the largest in the Institute’s history-to establish the Helmsley Center for Genomic Medicine, a research center dedicated to decoding the common genetic factors underlying many complex chronic human diseases. The award, from the Leona M. and Harry B. Helmsley Charitable Trust, will support interdisciplinary research that paves the way to new therapies for chronic illnesses such as cancer, diabetes and Alzheimer’s disease. [Salk Institute for Biological Studies] Press Release

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NEW International Conference on Tissue Engineering (ICTE) 2013
June 6-8, 2013
Leiria, Portugal

Visit our events page to see a complete list of events in the extracellular matrix community.


Postdoctoral Position – Tissue Engineering (Weizmann Institute of Science)

Staff Scientist – Stem Cell-Based Therapy Manufacturing (City of Hope Medical Group)

Early Stage Researcher – Laser-Made 3D Scaffolds for Tissue Engineering Applications (FORTH)

Postdoctoral Fellow – Cell-Extracellular Matrix Interactions in Cardiovascular Development & Disease (Thomas Jefferson University)

Postdoctoral Fellow (Medical University of Warsaw, Poland)

Postdoctoral Position – Tissue Development, Homeostasis and Malignancy (University of Oulu)

Postdoctoral Position – Extracellular Matrix & Developmental Biology (Purdue University)

Postdoctoral Position (Nencki Institute of Experimental Biology)

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