Volume 3.47 | Nov 29

Extracellular Matrix News 3.47 November 29, 2012

     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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Templated Agarose Scaffolds for the Support of Motor Axon Regeneration into Sites of Complete Spinal Cord Transection
Investigators examined whether template agarose scaffolds seeded with bone marrow stromal cells secreting brain-derived neurotrophic factor would support regeneration into severe, complete spinal cord transection sites. [Biomaterials] Abstract

New: Directed Differentiation of Pluripotent Stem Cells
PUBLICATIONS (Ranked by impact factor of the journal)

Syndecan-4 Signaling via NFAT Regulates Extracellular Matrix Production and Cardiac Myofibroblast Differentiation in Response to Mechanical Stress
Scientists examined the potential roles of the transmembrane proteoglycan syndecan-4 and the calcineurin-dependent transcription factor nuclear factor of activated T-cells (NFAT) in myofibroblast differentiation. [J Mol Cell Cardiol] Abstract

Sulfated Hyaluronan Containing Collagen Matrices Enhance Cell-Matrix-Interaction, Endocytosis, and Osteogenic Differentiation of Human Mesenchymal Stromal Cells
Researchers investigated the influence of artificial extracellular matrix composed of collagen type I and hyaluronan or sulfated hyaluronan on the molecular adaptation of osteogenic-differentiated human mesenchymal stromal cells. [J Proteome Res] Abstract

Fetal Fibronectin Signaling Induces Matrix Metalloproteinases and COX-2 in Amnion Cells and Preterm Birth in Mice
Scientists investigated the pathological function of fetal fibronectin on cell type-specific matrix metalloproteinases and prostaglandin synthesis in fetal membranes. [J Biol Chem] Abstract | Full Article

Hyaluronan (HA) Interacting Proteins Receptor for Hyaluronan Mediated Motility and Hyaluronidase Impact Prostate Cancer Cell Behavior and Invadopodia Formation in 3D HA-Based Hydrogels
To study the individual functions of hyaluronan interacting proteins in prostate cancer motility through connective tissues, investigators developed a novel three-dimensional (3D) HA hydrogel assay that provides a flexible, quantifiable, and physiologically relevant alternative to current methods. [PLoS One] Full Article

Fibronectin-Integrin Signaling Is Required for L-Glutamine’s Protection against Gut Injury
Researchers aimed to investigate if extracellular matrix stabilization and fibronectin-integrin osmosensing pathways are related to L-glutamine’s cell protective mechanism in the intestine. [PLoS One] Full Article

Hyaluronic Acid-Dependent Protection in H9C2 Cardiomyocytes: A Cell Model of Heart Ischemia Reperfusion Injury and Treatment
The authors aimed to in vitro investigate whether hyaluronic acid is able to reduce reactive oxygen species-induced heart ischemia-reperfusion injury and activate the cardiomyocyte’s damage surveillance systems. [Toxicology] Abstract

The Effect of Collagen Nerve Conduits Filled with Collagen-Glycosaminoglycan Matrix on Peripheral Motor Nerve Regeneration in a Rat Model
Investigators hypothesized that providing a synthetic mimic of the Schwann cell basal lamina in the form of a collagen-glycosaminoglycan matrix would improve the bridging of the nerve gap and functional motor recovery. [J Bone Joint Surg Am] Abstract

Channeled Scaffolds Implanted in Adult Rat Brain
Scaffolds with aligned channels based on acrylate copolymers were studied as colonizable structures both in vitro with neural progenitor cells and in vivo, implanted without cells in two different locations, in the cortical plate of adult rat brains and close to the subventricular zone. [J Biomed Mater Res Part A]
Abstract | Press Release

Compression-Induced Alignment and Elongation of Human Mesenchymal Stem Cell (hMSC) in 3D Collagen Constructs Is Collagen Concentration Dependent
The authors aimed to investigate the collagen concentration dependence of the compression-induced hMSC organization. Results demonstrated that the compression-induced alignment and elongation of hMSCs exhibited a biphasic dose-dependent relationship with collagen concentration, and associated well with both collagen ligand density and elastic modulus of the constructs. [J Biomed Mater Res Part A] Abstract

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Engineering Approaches for Investigating Tumor Angiogenesis: Exploiting the Role of the Extracellular Matrix
The authors explored how the emerging engineering approaches are being used to unlock the complex mechanisms regulating tumor angiogenesis. Emphasis is placed on models using natural and synthetic biomaterials to generate scaffolds mimicking the extracellular matrix, which is known to play a critical role in angiogenesis. [Cancer Res] Abstract

IntelliCell BioSciences Announces Research Agreement with the New Jersey Center for Biomaterials at Rutgers-The State University of New Jersey
IntelliCell BioSciences, Inc. announced that it has entered a sponsored research agreement with the New Jersey Center for Biomaterials at Rutgers-The State University of New Jersey. Initial research will focus on documenting any differences between IntelliCell’s proprietary cellular population and similar cell populations isolated from human adipose tissue using conventional methods of cell isolation. [PR Newswire Association LLC] Press Release

Stem Cell Pioneer Recognized for 20 Years of Discovery and Innovation
Dr. David Harris, Professor of Immunology at the University of Arizona and a scientific pioneer in the field of stem cell banking, was the recipient of the Arizona BioIndustry Association™ 2012 award for “20 Years of Discovery and Innovation”. Dr. Harris is a graduate of Wake Forest University, the leading center for stem cell regenerative medicine and tissue engineering in the world. [Adicyte, Inc] Press Release


National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


NEW Gordon Research Seminar – Collagen
July 13-14, 2013
New London, United States

Visit our events page to see a complete list of events in the extracellular matrix community.


Scientist or Engineer – hPSC Bioengineer (STEMCELL Technologies, Inc.)

Product Quality Scientist (STEMCELL Technologies, Inc.)

Scientist – Endothelial Cell Research (STEMCELL Technologies, Inc.)

Scientist or Engineer – hPSC Bioengineer (STEMCELL Technologies, Inc.)

Quality Control Analyst (STEMCELL Technologies, Inc.)

Research Technologist – Cell Separation (STEMCELL Technologies, Inc.)

Postdoctoral Position – Tissue Engineering (Weizmann Institute of Science)

Postdoctoral Position – Matrix Biology (University of Washington)

Postdoctoral Position(s) – Nanomedicine/Bioengineering (Ian Wark Research Institute)

Postdoctoral Position(s) – Nanotechnology, Scaffold Engineering, and Biomaterials (University of Michigan)

Senior Researcher Position – Biomaterials for Regenerative Medicine (University of Aveiro)

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