Volume 3.32 | Aug 16

Extracellular Matrix News 3.32 August 16, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Mechanical Force Regulates Integrin Turnover in Drosophila In Vivo
Researchers suggest that integrin-extracellular matrix adhesive stability is continuously controlled by force in vivo through integrin-dependent auto-regulatory feedback mechanisms so that tissues can quickly adapt to and withstand mechanical stresses. [Nat Cell Biol] Abstract

Air-Liquid Interface Culture for Respiratory Research: Watch Q&A Video
PUBLICATIONS (Ranked by impact factor of the journal)

A Candida albicans Biofilm-Induced Pathway for Matrix Glucan Delivery: Implications for Drug Resistance
Scientists identified three glucan modification enzymes that function to deliver glucan from the cell to the extracellular matrix. They showed that the enzymes are crucial for both delivery of β-1,3 glucan to the biofilm matrix and for accumulation of mature matrix biomass. [PLoS Pathog] Full Article

Hyaluronic Acid-Human Blood Hydrogels for Stem Cell Transplantation
Researchers aimed to develop and characterize a naturally-derived, autologous, biodegradable hydrogel in order to improve acute stem cell retention in the myocardium. [Biomaterials] Abstract

Light Activated Cell Migration in Synthetic Extracellular Matrices
Scientists demonstrated a strategy for manipulating individual mammalian stem cells in defined synthetic hydrogels through selective optical activation of Rac, an intracellular signaling protein that plays a key role in cell migration. [Biomaterials] Abstract

Modeling In Vivo Skeletal Muscle Aging In Vitro Using Three-Dimensional Bioengineered Constructs
Researchers suggest that three-dimensional bioengineered skeletal muscle constructs represent an in vitro model of the in vivo cell niche with multiple population doubled constructs displaying similar characteristics to aging/atrophied muscle in vivo. [Aging Cell] Abstract 

A Novel Mutation in β Integrin Reveals an Integrin-Mediated Interaction between the Extracellular Matrix and cki-1/p27KIP1
Scientists demonstrated that the β integrin PAT-3 regulates the localization and expression of cyclin dependent kinase inhibitor 1 (CKI-1). [PLoS One] Full Article

Nanopatterned Cardiac Cell Patches Promote Stem Cell Niche Formation and Myocardial Regeneration
Researchers combined autologous cardiosphere-derived cells with nanotopographically defined hydrogels mimicking the native myocardial matrix, to form in vitro cardiac stem cell niches, and control cell function and fate. [Integr Biol] Abstract

Full-Thickness Skin Wound Healing Using Human Placenta-Derived Extracellular Matrix Containing Bioactive Molecules
Results suggested that human placenta-derived extracellular matrix sheets provide microenvironment favorable to the growth and differentiation of cells, and positive modulate the healing of full-thickness wounds. [Tissue Eng Part A] Abstract

Biodegradable Scaffold Fabricated of Electrospun Albumin Fibers: Mechanical and Biological Characterization
Scientists presented a fibrous scaffold comprised solely of albumin. The scaffold was fabricated using the electrospinning method, and resulted in micro-scale fibers that demonstrated mechanical properties similar to those of elastin fibers, a common component of connective tissue extracellular matrix. [Tissue Eng Part C Methods] Abstract

Learn more about the new smartphone app for human blood cell frequencies

INDUSTRY NEWS

Professor Receives NIH Grant to Study Collagen Peptides as a Cancer Treatment Delivery Method
Katarzyna Slowinska, an associate professor of chemistry at California State University, Long Beach, has received a four-year, $433,500 grant from the National Institute of Health’s (NIH) National Institute of General Medical Sciences to pursue using short strands of amino acids called peptides to serve as drug nanocarriers. [California State University, Long Beach] Press Release

Shu-Tung Li, Founder and Chief Executive Officer of Collagen Matrix, Inc. Selected for Induction into the New Jersey Inventors Hall of Fame
Collagen Matrix, Inc. announced that Dr. Shu-Tung Li was selected as a 2012 inductee into the New Jersey Inventors Hall of Fame co-sponsored by Stevens Institute of Technology and Greenberg Traurig, LLP. His award recognition is for “Patented Technology Related to: Collagen based medical implants for the repair and regeneration of soft tissue and bones.” [PR Newswire Association LLC] Press Release

Stem Cell Society Singapore Symposium 2012 - Stem Cell Based Therapy

POLICY NEWS

Inquiry Launch: Regenerative Medicine
The House of Lords Science and Technology Committee have launched an inquiry into regenerative medicine. The Committee will consider whether the UK is in a position to support the translation of knowledge from world-leading research in the field of regenerative medicine to treatments, and to benefit from the associated commercial opportunities. [House of Lords Science and Technology Committee, United Kingdom]
Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW American Society for Investigative Pathology (ASIP) 2013 Annual Meeting
April 20-24, 2013
Boston, United States

Visit our events page to see a complete list of events in the extracellular matrix community.

JOB OPPORTUNITIES

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)


Research Technologist – Research and Development (STEMCELL Technologies, Inc.)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)


Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Assistant Professor – Cell Biology and Physiology (Washington University School of Medicine)

Assistant Professor – Cell and Extracellular Matrix Research (University of Oulu)


Postdoctoral Research Position – Molecular Cell Biology (Weizmann Institute of Science)

Professor – Molecular Cell-Extracellular Matrix Interplay (University of Oulu)


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