Volume 3.24 | Jun 21

Extracellular Matrix News 3.24 June 21, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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Synergistic Effects of Hypoxia and Extracellular Matrix Cues in Cardiomyogenesis
Scientists evaluated the expression of four extracellular matrix proteins – fibronectin, collagen I, collagen IV, and laminin – over a period of 20 days in H1 and H9 human embryonic stem cell-derived embryoid bodies under hypoxic and normoxic conditions. [Biomaterials] Abstract

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PUBLICATIONS (Ranked by impact factor of the journal)

Proteomic Analysis of Extracellular Matrix from the Hepatic Stellate Cell Line LX-2 Identifies CYR61 and Wnt-5a as Novel Constituents of Fibrotic Liver
Scientists catalogued the components of fibrotic liver extracellular matrix to obtain insights into disease aetiology and aid identification of new biomarkers. [J Proteome Res] Abstract

Laminin Regulates Postnatal Oligodendrocyte Production by Promoting Oligodendrocyte Progenitor Survival in the Subventricular Zone
Researchers report that Lama2, the gene that encodes the laminin α2-subunit, regulates postnatal oligodendrogenesis. [Glia] Abstract

Decellularized Cartilage as a Novel Biomatrix for Cartilage Tissue Engineering Applications
Researchers developed and applied a novel chemical process to completely decellularize and sterilize human and porcine cartilage tissues to generate a new type of bio-implant matrix. To characterize this matrix, and determine the effect of the decellularization process, the content of denatured collagen and the content of glycosaminoglycans wG were determined. [Tissue Eng Part A] Abstract

Extracellular Matrix Assembly and Three-Dimensional Organization during Paraxial Mesoderm Development in the Chick Embryo
Investigators performed a detailed, three-dimensional analysis of the distribution of two extracellular matrix components, fibronectin and laminin, during the development of the chick paraxial mesoderm. [Dev Biol] Abstract

Endogenous Production of Fibronectin Is Required for Self-Renewal of Cultured Mouse Embryonic Stem Cells
Researchers showed that the ubiquitous extracellular matrix protein fibronectin is required for self-renewal decisions in cultured mouse embryonic stem cells. [Exp Cell Res] Abstract

Successful Recellularization of Human Tendon Scaffolds Using Adipose-Derived Mesenchymal Stem Cells and Collagen Gel
Scientists manufactured a recellularized biocompatible scaffold from cadaveric tissue for use in total or partial tendon injuries. [J Tissue Eng Regen Med] Abstract

Breast Epithelial Tissue Morphology Is Affected in Three-Dimensional Cultures by Species-Specific Collagen-Based Extracellular Matrix
Researchers explored whether collagen type I fibers with distinct biomechanical and fiber-assembling properties, isolated from either bovine or rat tail tendon, differentially affected the epithelial phenotype in a tissue culture model of the human breast. [J Biomed Mater Res A] Abstract

Genistein Attenuates Advanced Glycation End Product-Induced Expression of Fibronectin and Connective Tissue Growth Factor
Researchers investigated the effect of advanced glycation end products on the expression of connective tissue growth factor (CTGF) and fibronectin (FN) in human peritoneal mesothelial cells (HPMC). They also observed the effect of genistein on the expression of CTGF and FN in HPMC induced by advanced glycation end products. [Am J Nephrol] Abstract

Regional Variations in the Distribution and Colocalization of Extracellular Matrix Proteins in the Juvenile Bovine Meniscus
Regional variations in the tissue-level and pericellular distributions of collagen types I, II and VI and the proteoglycans aggrecan, biglycan and decorin were examined in the juvenile bovine meniscus. [J Anat] Abstract

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New Company Will Commercialize Worcester Polytechnic Institute’s Pioneering Research on Microthread Technology
Called VitaThreads LLC, the new company will build on the pioneering research of founders George Pins and Glenn Gaudette. VitaThreads will produce biopolymer threads and sutures for tissue regeneration, wound healing, and cell therapy applications. [Worcester Polytechnic Institute] Press Release

Shire’s Advanced BioHealing Commits to Developing Regenerative Medicine Campus
Shire plc announced that its Regenerative Medicine business, Advanced BioHealing, Inc., has entered into a lease agreement with BioMed Realty Trust, Inc. which will allow the company to further expand its operational footprint and presence in the San Diego area over the next several years. [Shire plc] Press Release


National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


NEW The 10th International Association of Science and Technology for Development (IASTED) International Conference on Biomedical Engineering
February 13-15, 2013
Innsbruck, Austria

Visit our events page to see a complete list of events in the extracellular matrix community.

Research Associate – Chemistry (STEMCELL Technologies, Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)

Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Postdoctoral Research Fellow – Protein Chemistry/Immuno-Receptor Biology (Genentech)

Postdoctoral Research Position – Molecular Cell Biology (Weizmann Institute of Science)

Assistant Professor – Cell and Extracellular Matrix Research (University of Oulu)

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