Volume 3.21 | May 31

Extracellular Matrix News 3.21 May 31, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Extracellular Matrix Tethering Regulates Stem Cell Fate
Scientists found that stem cells exert a mechanical force on collagen fibers and gauge the feedback to make cell-fate decisions. [Nat Mater] Abstract

Learn more about the new smartphone app for human blood cell frequencies
PUBLICATIONS (Ranked by impact factor of the journal)

In Vitro Microvessels for the Study of Angiogenesis and Thrombosis
Scientists engineered living microvascular networks in three-dimensional tissue scaffolds and demonstrated their biofunctionality in vitro. [Proc Natl Acad Sci USA] Abstract | Press Release

High-Throughput Cellular Screening of Engineered Extracellular Matrix Based on Combinatorial Polyelectrolyte Multilayer Films
Researchers developed a combinatorial method to generate coatings that self assemble from solutions of polyelectrolytes in water, layer by layer, to produce a polyelectrolyte multilayer coating that has enabled high-throughput screening for cellular biocompatibility. [Biomaterials] Abstract

Confluence Switch Signaling Regulates ECM Composition and Plasmin Proteolytic Cascade in Keratinocytes
Scientists demonstrated that confluence dependent-signaling orchestrates not only growth-inhibition and differentiation but also controls extracellular matrix (ECM)-proteolysis and basement membrane formation. [J Cell Sci] Abstract

Oriented Lamellar Silk Fibrous Scaffolds to Drive Cartilage Matrix Orientation: Towards Annulus Fibrosus Tissue Engineering
By offering the combined effect of cell/matrix alignment and chondrogenic support, the developed silk fibroin scaffolds with precise fiber orientation in lamellar form represent a suitable substrate for tissue engineering of the annulus fibrosus part of intervertebral disc. [Acta Biomater] Abstract

Proteomic Analysis of α4β1 Integrin Adhesion Complexes Reveals α-Subunit-Dependent Protein Recruitment
Researchers report the isolation of ligand-induced adhesion complexes associated with wild-type α4β1 integrin, an activated α4β1 variant in the absence of the α cytoplasmic domain and a chimeric α4β1 variant with α5 leg and cytoplasmic domains, and the cataloguing of their proteomes by MS. [Proteomics] Abstract

Prostaglandins but Not Leukotrienes Alter Extracellular Matrix Protein Deposition and Cytokine Release in Primary Human Airway Smooth Muscle Cells and Fibroblasts
Increasing evidence suggests that eicosanoids may directly mediate remodeling. Researchers assessed whether these substances could alter extracellular matrix proteins and the inflammatory profiles of primary human airway smooth muscle cells and fibroblasts. [Am J Physiol Lung Cell Mol Physiol] Abstract

Beta3 Integrin Modulates Transforming Growth Factor Beta Induced (TGFBI) Function and Paclitaxel Response in Ovarian Cancer Cells 
Scientists suggest that different extracellular matrix components use distinct signaling mechanisms in ovarian cancer cells and in particular, that TGFBI preferentially interacts through a beta3 integrin receptor mediated mechanism to regulate the response of cells to paclitaxel-induced cell death. [Mol Cancer]
Abstract | Full Article

Extracellular Matrix Constituents Interfere with Newcastle Disease Virus Spread in a Solid Tissue and Diminishes Its Potential Oncolytic Activity
The results of this study indicate that the extracellular matrix acts as a barrier to virus spreading within solid tumor tissues and that this restriction must be overcome to achieve effective oncolysis with Newcastle disease virus. [J Gen Virol] Abstract

Comparison of Decellularization Techniques for Preparation of Extracellular Matrix Scaffolds Derived from Three-Dimensional Cell Culture
Scientists developed a method to prepare cultured cell-derived extracellular matrix scaffolds by combining three-dimensional cell culture, decellularization, and selective template removal. [J Biomed Mater Res A] Abstract

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INDUSTRY NEWS

Maryland Stem Cell Research Commission Funds 40 New Proposals in FY 2012
The board of directors of the Maryland Technology Development Corporation approved the Commission’s recommendation to fund 40 new proposals with the Maryland Stem Cell Research Fund’s $12.4 million FY 2012 budget. [Maryland Stem Cell Research Fund] Press Release

Biostem US, Corporation Appoints Philip A. Lowry, MD as Chairman of Its Scientific and Medical Board of Advisors
Biostem U.S., Corporation announced that Philip A. Lowry, MD, has been appointed as the Chairman of its Scientific and Medical Board of Advisors. [Biostem U.S.] Press Release

POLICY NEWS

White House Petitioned to Make Research Free to Access
More than 17,000 people have signed an online petition urging US President Barack Obama to require all scientific journal articles resulting from US taxpayer-funded research to be made freely available online. [White House, United States] Press Release

Horizon 2020: A €80 Billion Battlefield for Open Access
As negotiations proceed to shape the next installment of Europe’s gargantuan research funding programs, scientists, librarians, and publishers are eagerly awaiting the answer to a critical question: How strong will the new seven-year program, called Horizon 2020, be on Open Access? [European Commission, European Union] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW American Society for Bone and Mineral Research (ASBMR) 2012 Annual Meeting
October 12-15, 2012
Minneapolis, United States

Visit our events page to see a complete list of events in the extracellular matrix community.

JOB OPPORTUNITIES
Research Associate – Chemistry (STEMCELL Technologies, Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)


Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)


Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)


Postdoctoral Research Fellow – Protein Chemistry/Immuno-Receptor Biology (Genentech)


Postdoctoral Research Position – Molecular Cell Biology (Weizmann Institute of Science)

Postdoctoral Positions – Cell-Extracellular Matrix Research (Finnish Centre of Excellence in Cell-Extracellular Matrix Research)

Temporary Research Associate Position – Extracellular Matrix and Stem Cell Application in Regenerative Medicine (Università di Pisa)


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