Volume 3.19 | May 17

Extracellular Matrix News 3.19, May 17, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
The Effect of Source Animal Age upon the In Vivo Remodeling Characteristics of an Extracellular Matrix Scaffold
Researchers compared the in vivo host response and remodeling outcomes of biologic scaffolds composed of small intestinal submucosa-extracellular matrix harvested from pigs that differed only in age. [Biomaterials] Abstract

Neurosphere or Adherent Monolayer Culture? Watch the Video to Learn How NeuroCult Does Both.
PUBLICATIONS (Ranked by Impact Factor of the Journal)

Single-Molecule Tracking of Collagenase on Native Type I Collagen Fibrils Reveals Degradation Mechanism
Findings provide a mechanistic paradigm for type I collagen degradation by matrix metalloprotease-1 (MMP1) and establish a general approach to investigate MMP-fibrillar collagen interactions. [Curr Biol] Abstract

Collagen XII and XIV – New Partners of Cartilage Oligomeric Matrix Protein in the Skin Extracellular Matrix Suprastructure
Investigators postulated that cartilage oligomeric matrix protein functions as an adapter protein in human skin, similar to its function in cartilage extracellular matrix, by organizing collagen I fibrils into a suprastructure mainly in the vicinity of anchoring plaques that stabilizes the cohesion between the upper dermis and the basement membrane zone. [J Biol Chem] Full Article

Extracellular Matrix Mineralization Promotes E11/gp38 Glycoprotein Expression and Drives Osteocytic Differentiation
Scientists investigated whether extracellular matrix mineralization could promote osteocyte formation. [PLoS One] Full Article

Alternation of Extracellular Matrix Remodeling and Apoptosis by Activation of the Aryl Hydrocarbon Receptor Pathway in Human Periodontal Ligament Cells
Researchers investigated the effects of benzo(a)pyrene on the extracellular matrix remodeling-related molecules, collagen type I, matrix metalloproteinase-1, alpha-smooth muscle actin expression and apoptosis in two different human periodontal ligament cells. [J Cell Biochem] Abstract

Arabinogalactan Proteins and the Extracellular Matrix Surface Network during Peach Palm Somatic Embryogenesis
Results correspond to an extracellular matrix surface network (ECMSN) associated with the development of somatic embryos and closely related to the expression of MAb JIM13. Scanning electron microscopy confirmed the presence of an ECMSN covering a specific group of cells and ultra-structural analyses revealed that the ECMSN had lipophilic substances. [Physiol Plant] Abstract

Parenchymal-Stromal Switching for Extracellular Matrix Production on Invasion of Oral Squamous Cell Carcinoma
Scientists studied the expression of four extracellular matrix molecules at the protein and messenger RNA levels in monocellular and two kinds of coculture systems between human squamous cell carcinoma and fibroblast cell lines, which may correspond to carcinoma in situ and squamous cell carcinoma, respectively. [Hum Pathol] Abstract

Electrospun Nanostructured Chitosan-Poly(Vinyl Alcohol) Scaffolds: A Biomimetic Extracellular Matrix as Dermal Substitute
Researchers electrospun and characterized chitosan (C)-poly(vinyl alcohol) (PVA) blend nanofibers as dermal substitutes and compared with two-dimensional C-PVA films. [Biomed Mater] Abstract

Listen Now: New Podcast on ALDH in Breast Cancer Treatment Response

INDUSTRY NEWS

Angel Biotechnology Holdings plc Announces Acquisition of Assets of Biomaterial Manufacturing Business, Launch of Angel Biomedical Limited
Angel Biotechnology Holdings plc announced with immediate effect the acquisition of the assets of an established biomaterial and collagen manufacturing business, through its newly formed and wholly owned subsidiary, Angel Biomedical Ltd. [Angel Biotechnology Holdings plc] Press Release

New Teva Representative Joins Mesoblast Board of Directors
Global regenerative medicine company Mesoblast Limited announced the appointment of Dr Ben-Zion Weiner as a non-executive Director of Mesoblast. [Mesoblast Limited] Press Release

POLICY NEWS

A Global Standard for Peer Review
After winning the strong backing of the White House, Subra Suresh convened a meeting of 47 leaders of research funding agencies from 44 countries. At the conclusion of closed-door sessions, the group will issue the first-ever global statement on the principles of merit review. [National Science Foundation, United States]
Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW World Stem Cells & Regenerative Medicine Congress 2013
March 18-21, 2013
Singapore, Singapore

Visit our events page to see a complete list of events in the extracellular matrix community.

JOB OPPORTUNITIES
Research Associate – Chemistry (STEMCELL Technologies, Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)


Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)


Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)


Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)


Postdoctoral Research Fellow – Protein Chemistry/Immuno-Receptor Biology (Genentech)


Postdoctoral Research Position – Molecular Cell Biology (Weizmann Institute of Science)

Postdoctoral Positions – Cell-Extracellular Matrix Research (Finnish Centre of Excellence in Cell-Extracellular Matrix Research)


Temporary Research Associate Position – Extracellular Matrix and Stem Cell Application in Regenerative Medicine (Università di Pisa)


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