Volume 3.14 | Apr 12

Extracellular Matrix News 3.14, April 12, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Osteopontin Is a Novel Downstream Target of SOX9 with Diagnostic Implications for Progression of Liver Fibrosis in Humans
Scientists’ data reinforce sex-determining region Y-box 9 (SOX9) as a core factor mediating expression of extracellular matrix components involved in liver fibrosis. [Hepatology] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Injectable and Thermo-Sensitive PEG-PCL-PEG Copolymer/Collagen/n-HA Hydrogel Composite for Guided Bone Regeneration
A novel three-component biomimetic hydrogel composite was successfully prepared in this study, which was composed of triblock PEG-PCL-PEG copolymer, collagen and nano-hydroxyapatite (n-HA). [Biomaterials] Abstract

Estradiol Protects the Dermal Hyaluronan/Versican Matrix during Photoaging by Release of Epidermal Growth Factor from Keratinocytes
Researchers aimed to explore the molecular mechanisms mediating the effects of estrogen on hyaluronan-rich extracellular matrix during photoaging. [J Biol Chem] Abstract

O-Linked LacdiNAc-Modified Glycans in Extracellular Matrix Glycoproteins Are Specifically Phosphorylated at the Subterminal GlcNAc
In searching for mammalian proteins modified with O-linked LacdiNAc, researchers identified six positive species among nine endogenous and recombinant O-glycoproteins, which were extracellular matrix, or matrix-related proteins. [J Biol Chem] Abstract

Effects of Cryopreservation, Decellularization and Novel ECM Conditioning on the Quasi-Static and Time-Dependent Properties of the Pulmonary Valve Leaflet
The stress-strain, relaxation and creep behavior of the ovine pulmonary valve leaflet was investigated under planar-biaxial loading conditions to determine the effects of decellularization and a novel post-decellularization extracellular matrix (ECM) conditioning process. [Acta Biomater] Abstract

Granzyme B Cleaves Decorin, Biglycan and Soluble Betaglycan, Releasing Active Transforming Growth Factor-β1
Researchers’ objective was to identify proteoglycan (PG) substrates of granzyme B (GrB) and examine the ability of GrB to release PG-sequestered transforming growth factor-β1 into the extracellular milieu. [PLoS One] Abstract

Increased Fibrosis and Interstitial Fluid Pressure in Two Different Types of Syngeneic Murine Carcinoma Grown in Integrin β3-Subunit Deficient Mice
Scientists show that αVβ3 expressed by stromal cells is involved in the control of interstitial fluid pressure, extracellular volume and collagen scaffold architecture in experimental murine carcinoma. [PLoS One] Abstract

Survival of Cord Blood Hematopoietic Stem Cells in a Hyaluronan Hydrogel for Ex Vivo Biomimicry
A hyaluronic acid scaffold has been used for the first time to maintain long-term cultures of CD34+ hematopoietic cells obtained from human cord blood. [J Tissue Eng Regen Med] Abstract

Integrin-Mediated Adhesion of Human Mesenchymal Stem Cells to Extracellular Matrix Proteins Adsorbed to Polymer Surfaces
Researchers have investigated the ability of human bone marrow derived stem cells to adhere to extracellular matrix proteins, including fibronectin and vitronectin which are present in plasma and serum. [Biomed Mater] Abstract

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INDUSTRY NEWS

American CryoStem, PGen to Develop Stem Cells for Wound Healing
American CryoStem and Protein Genomics (PGen) have agreed to work together to develop cellular therapies for the wound healing and other regenerative markets. [Genetic Engineering & Biotechnology News]
Press Release

ACOS and Avedro Announce Initiation of a Phase III Study on Accelerated Corneal Cross-Linking
ACOS (The American-European Congress of Ophthalmic Surgery) and Avedro, Inc. jointly announced the initiation of a Phase III, multi-center, randomized, controlled evaluation to study accelerated corneal collagen cross-linking in eyes with keratoconus or corneal ectasia after refractive surgery. [Avedro, Inc.]
Press Release

Smith Medical Partners Announces Logistics Agreement for Cardium’s National Distribution of Excellagen™
Smith Medical Partners announced an exclusive logistics and cold chain services agreement with Cardium Therapeutics to support its recently launched wound care product, Excellagen™. [Smith Medical Partners] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW 3rd Tissue Engineering and Regenerative Medicine International Society (TERMIS) World Congress
September 5-8, 2012
Vienna, Austria

Visit our events page to see a complete list of events in the extracellular matrix community.

JOB OPPORTUNITIES
Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)


Scientist – Hematology (STEMCELL Technologies, Inc.)

Scientist – hPSC (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)


Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Postdoctoral Position (Thomas Jefferson University)


Postgraduate Position – Cutaneous Biology (Northwestern University) 


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