Volume 3.13 | Apr 5

Extracellular Matrix News 3.13, April 5, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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Tissue Specific Synthetic ECM Hydrogels for Three-Dimensional In Vitro Maintenance of Hepatocyte Function
Researchers investigated whether extracts prepared from acellular liver extracellular matrix (ECM), or from whole liver tissue, could be combined with collagen type I, hyaluronic acid (HA), or heparin-conjugated HA hydrogels to enhance survival and functional output of primary human hepatocytes. [Biomaterials] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Hyaluronan Impairs Vascular Function and Drug Delivery in a Mouse Model of Pancreatic Cancer
Scientists examined the role of an abundant extracellular matrix component, the megadalton glycosaminoglycan hyaluronan, as a novel therapeutic target in pancreatic ductal adenocarcinoma. [Gut] Abstract

N-Cadherin-Mediated Cell-Cell Adhesion Promotes Cell Migration in a Three-Dimensional Matrix
Using hepatocyte growth factor-treated MDCK cells that underwent a complete epithelial-to-mesenchymal transition, researchers analyzed cell-cell adhesion between these highly invasive transformed epithelial cells in a three-dimensional collagen matrix. [J Cell Sci] Abstract

MT1-MMP-Dependent Remodeling of Cardiac Extracellular Matrix Structure and Function following Myocardial Infarction
This study identified MT1-matrix metalloproteinase (MMP) as a key MMP responsible for effecting postinfarction cardiac extracellular matrix remodeling and cardiac dysfunction. [Am J Pathol] Abstract

Three-Dimensional Electrospun Poly(Lactide-co-ε-Caprolactone) for Small Diameter Vascular Grafts
Researchers studied small diameter vascular grafts in vitro by seeding smooth muscle cells on the electrospun poly(lactide-co-ε-caprolactone) scaffolds, culturing and constructing a three-dimensional network. [Tissue Eng Part A] Abstract

Matrix Stiffness-Induced Myofibroblast Differentiation Is Mediated by Intrinsic Mechanotransduction
Researchers aimed to determine the intrinsic mechanisms of mechanotransduction in the regulation of matrix stiffness-induced myofibroblast differentiation. [Am J Respir Cell Mol Biol] Abstract

Heparin Interacting Protein Mediated Assembly of Nano-Fibrous Hydrogel Scaffolds for Guided Stem Cell Differentiation
These studies demonstrated that a nano-fibrous hyaluronic acid hydrogel can render the formulation of a therapeutically effective platform for in vitro adipogenesis applications. [Macromol Biosci] Abstract

Age Impacts Extracellular Matrix Metabolism in Chondrocytes Encapsulated in Degradable Hydrogels
Scientists compare extracellular matrix anabolic and catabolic metabolisms by juvenile and adult chondrocytes in hydrolytically degradable hydrogels. [Biomed Mater] Abstract

Improved Cartilage Repair via In Vitro Pre-Maturation of MSC-Seeded Hyaluronic Acid Hydrogels
Researchers assess both the maturation and integration of mesenchymal stem cell (MSC)-laden hyaluronic acid hydrogels in an in vitro cartilage defect model. [Biomed Mater] Abstract

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Cardium Announces U.S. Market Introduction of Excellagen™
Cardium Therapeutics announced market introduction of its Excellagen™ professional-use, syringe-based wound care product for the management of diabetic foot ulcers, pressure ulcers and other dermal wounds. [Cardium Therapeutics] Press Release

REMEDI Announces Collaborations with Chinese Universities
The Regenerative Medicine Institute (REMEDI) announced collaborations with both Shanghai Jiao Tong University and the Fourth Medical Military University Hospital in Xi’an. The agreement will see REMEDI work closely with both Chinese partners in a number of research areas and will facilitate student and researcher exchange between Galway and China. [The Regenerative Medicine Institute] Press Release


National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


NEW The 2nd International Symposium of Materials on Regenerative Medicine
August 29-31, 2012
Taipei, Taiwan

Visit our events page to see a complete list of events in the extracellular matrix community.

Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Hematology (STEMCELL Technologies, Inc.)

Scientist – hPSC (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Postdoctoral Position (Thomas Jefferson University)

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