Volume 3.03 | Jan 26

Extracellular Matrix News 3.03, January 26, 2012
     In this issue: PublicationsIndustry News | Policy News | Events | Jobs
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TOP STORY
Proteomics Analysis of Cardiac Extracellular Matrix Remodeling in a Porcine Model of Ischemia-Reperfusion Injury
In this study researchers have applied a novel proteomic method for the analysis of extracellular matrix in cardiovascular tissues to a porcine model of ischemia-reperfusion injury. [Circulation] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Biologic Scaffold Composed of Skeletal Muscle Extracellular Matrix
The present study describes an enzymatic and chemical decellularization process for isolating skeletal muscle extracellular matrix (ECM) scaffolds using established decellularization criteria and characterized the structure and chemical composition of the resulting ECM. [Biomaterials] Abstract

The Influence of Chitosan Hydrogel on Stem Cell Engraftment, Survival and Homing in the Ischemic Myocardial Microenvironment
Researchers explored an injectable chitosan hydrogel for stem cell delivery into ischemic heart and investigated the beneficial effects and mechanisms of the hydrogel. [Biomaterials] Abstract

Self-Attaching and Cell-Attracting In Situ Forming Dextran-Tyramine Conjugates Hydrogels for Arthroscopic Cartilage Repair
Researchers’ in vitro and ex vivo functional studies evidenced the covalent bonding of tyramine-containing hydrogels to tyrosine residues in cartilaginous matrix proteins. [Biomaterials] Abstract

Chondrogenic Differentiation of Rat MSCs on Porous Scaffolds of Silk Fibroin/Chitosan Blends
Researchers compared the formation of cartilaginous tissue in the silk fibroin/chitosan blended scaffolds with rat mesenchymal stem cells (MSCs) and cultured in vitro for 3 weeks. [Biomaterials] Abstract

Antiatherosclerotic Effect of an Antibody that Binds to Extracellular Matrix Glycosaminoglycans
The aim of this study was to characterize the recognition and antiatherogenic properties of a chimeric monoclonal antibody that reacts with sulfated molecules. [Arterioscler Thromb Vasc Biol] Abstract

Association of Randall Plaque with Collagen Fibers and Membrane Vesicles
Researchers hypothesized that Randall plaque formation is similar to that of vascular calcification, involving components of extracellular matrix, including membrane bound vesicles and collagen fibers. [J Urol] Abstract

Passive Mechanical Properties of Rat Abdominal Wall Muscles Suggest an Important Role of the Extracellular Connective Tissue Matrix
Researchers found that extracellular connective tissue matrix provided a stiffening effect and enhanced the resistance to lengthening at long muscle lengths. [J Orthop Res] Abstract

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INDUSTRY NEWS

Penn Lung Biologists to Receive $2.5 Million to Study Repair and Regeneration
The Perelman School of Medicine at the University of Pennsylvania (Penn) is one of six institutions to be named part of the National Heart, Lung, and Blood Institute’s Lung Repair and Regeneration Consortium. Each of the institutions will receive $2.5 million over five years. [Perelman School of Medicine, University of Pennsylvania] Press Release

Academic Institutions Won Most of the California Institute for Regenerative Medicine’s $1.3 Billion in Awards over Past Five Years
Focus of California’s stem cell agency has been on setting up a foundation for leadership. [Genetic Engineering & Biotechnology News] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW European Society of Cardiology – Frontiers in Cardiovascular Biology 2012
March 30-April 1, 2012
London, United Kingdom

Visit our events page to see a complete list of events in the extracellular matrix community.
JOB OPPORTUNITIES

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Postdoctoral Positions – Tissue-Engineering (Sabanci University)

Postdoctoral Fellow (Mount Sinai School of Medicine)


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