Volume 3.00 | Jan 5

Extracellular Matrix News 3.00, January 5, 2012
     In this issue: PublicationsIndustry News | Policy News | Events | Jobs
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TOP STORY

Extracellular Matrix in Airway Smooth Muscle Is Associated with Dynamics of Airway Function in Asthma
First, researchers investigated the difference in extracellular matrix (ECM) expression in airway smooth muscle between asthma and controls. Second, they examined whether ECM expression is associated with bronchoconstriction and bronchodilation in vivo. [Allergy] Abstract


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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Integrins Regulate Repulsion-Mediated Dendritic Patterning of Drosophila Sensory Neurons by Restricting Dendrites in a 2D Space
Removing neuronal integrins or blocking epidermal laminin production causes dendrites to grow into the epidermis, suggesting that integrin-laminin interaction attaches dendrites to the extracellular matrix. [Neuron] Abstract

Newly Visualized Fibrillar Collagen Scaffolds Dictate Entamoeba histolytica Invasion Route in the Human Colon
In this study, investigators determined the impact of the collagen fibers architecture on the invasive process of the enteric parasite Entamoeba histolytica. [Cell Microbiol] Abstract


Distinct Recycling of Active and Inactive β1 Integrins
Data provide new insights into the endocytic traffic of integrins and imply the possibility of a previously unappreciated cross-talk between pathways regulating integrin activity and traffic. [Traffic] Abstract


Micro- and Macrorheology of Jellyfish Extracellular Matrix
Investigators found that the extracellular matrix behaved as a viscoelastic gel at the macroscopic scale and as a much softer and heterogeneous viscoelastic structure at the microscopic scale. [Biophys J] Abstract


Altered Synaptic Marker Abundance in the Hippocampal Stratum Oriens of Ts65Dn Mice Is Associated with Exuberant Expression of Versican
The purpose of this study was to identify changes in synaptic structure in the hippocampus in a model of Down syndrome, the Ts65Dn mouse, and to determine the relationship to proteoglycan abundance and/or cleavage and cognitive disability. [ASN Neuro] Abstract


Maladaptive Matrix Remodeling and Regional Biomechanical Dysfunction in a Mouse Model of Aortic Valve Disease
The objective of this study was to examine extracellular matrix remodeling and biomechanical properties in regional aortic valve tissue and determine the impact of early aortic valve malformation on late aortic valve disease in the elastin insufficient mouse model. [Matrix Biol] Abstract

Mechanical Properties of Tyramine Substituted-Hyaluronan Enriched Fascia Extracellular Matrix
The objective of this study was to determine the extent to which tyramine substituted-hyaluronan treatment was associated with mechanical property changes of fascia after implantation in the rat model. [J Biomed Mater Res A] Abstract


Collagen-Silica Xerogel Nanohybrid Membrane for Guided Bone Regeneration
Findings suggest that the collagen-silica xerogel hybrid can be used as a guided bone regeneration membrane. [J Biomed Mater Res A] Abstract


Heparan Sulfate Niche for Cell Proliferation in the Adult Brain
To determine to which extent cell proliferation is associated with N-sulfated heparan sulfates (N-sulfated HS), investigators mapped N-sulfated HS and proliferating cells by immunohistochemistry throughout the adult mouse brain. [Neurosci Lett] Abstract


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INDUSTRY NEWS

Biomerix Receives CE Mark Approval For ASSURE Soft Tissue Repair Mesh
Biomerix Corporation announced that it has received CE Mark approval for its ASSURE soft tissue repair mesh, a novel composite mesh intended for the reconstruction of hernias and soft tissue deficiencies and for the temporary bridging of fascial defects. [Biomerix Corporation] Press Release


Rice’s Grande-Allen wins AHA Established Investigator Award
Rice University’s Jane Grande-Allen, one of the world’s foremost experts on the biomechanics of heart-valve tissue, has won an Established Investigator Award from the American Heart Association. Grande-Allen’s specialty is studying the unique biological and material properties of valves so doctors can better understand and treat valve disease. [Rice University] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Keystone Symposia on Molecular and Cellular Biology: Structural Biology of Cellular Processes
January 22-27, 2012
Keystone, United States

NEW Molecular Medicine Tri-Conference 2012
February 19-23, 2012
San Francisco, United States

Visit our events page to see a complete list of events in the extracellular matrix community.

JOB OPPORTUNITIES

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Postdoctoral Positions – Tissue-Engineering (Sabanci University)

Postdoctoral Position – Molecular Cell Biology (Weizmann Institute of Science)

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