Volume 2.48 | Dec 8

Extracellular Matrix News 2.48, December 8, 2011
     In this issue: PublicationsIndustry News | Policy News | Events | Jobs
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TOP STORY
The Involvement of Integrin β1 Signaling in the Migration and Myofibroblastic Differentiation of Skin Fibroblasts on Anisotropic Collagen-Containing Nanofibers
In this study, the phenotypic expressions of normal human dermal fibroblasts on collagen-containing nanofibrous matrices with either isotropic or anisotropic fiber organizations were studied by immunostaining, migration assay and molecular analyses. [Biomaterials] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Consequences of Ineffective Decellularization of Biologic Scaffolds on the Host Response
The objective of this study was to evaluate the consequences of ineffective decellularization on host response. [Biomaterials] Abstract

Dual Regulation of Breast Tubulogenesis Using Extracellular Matrix Composition and Stromal Cells
Here, researchers used a three dimensional in vitro culture to study the roles of stromal cells and extracellular matrix components during mammary tubulogenesis. [Tissue Eng Part A] Abstract

Feedback Regulation of the α2(1) Collagen Gene via the Mek-Erk Signaling Pathway
In this study, a fibroblast-derived extracellular matrix was used to study the feedback regulation of type I collagen synthesis in fibroblasts. [IUBMB Life] Abstract

The Effect of Valproic Acid and Oxcarbamazepine on the Distribution of Adhesion Molecules in Embryo Implantation
This study was intended to investigate the effect of valproate and oxcarbamazepine on embryo implantation in terms of extracellular matrix protein distribution. [Toxicology] Abstract

Age-Related Intimal Stiffening Enhances Endothelial Permeability and Leukocyte Transmigration
Using in vitro and ex vivo models of vessel wall stiffness and aging, researchers
 show that stiffening of extracellular matrix within the intima promotes endothelial cell permeability-a hallmark of atherogenesis. [Sci Transl Med] Abstract

SPARC Modulates Expression of Extracellular Matrix Genes in Human Trabecular Meshwork Cells
The purpose of this study was to investigate the effects of secreted protein acidic and rich in cysteine (SPARC) on the expression of components of the extracellular matrix in cultured human trabecular meshwork cells. [Acta Ophthalmol] Abstract

Cigarette Smoke Extract Induces Select Matrix Metalloproteinase and Integrin Expression in Periodontal Ligament Fibroblasts
This study examined the direct effect of smoking on periodontal ligament fibroblasts and their production of various matrix components and remodeling enzymes. [J Periodontol] Abstract

Potential of Healing a Transected Anterior Cruciate Ligament with Genetically Modified Extracellular Matrix Bioscaffolds in a Goat Model
This study examined the potential advantages of using extracellular matrix bioscaffolds from galactosyl-α(1,3)galactose deficient pigs to heal the transected anterior cruciate ligament. [Knee Surg Sports Traumatol Arthrosc] Abstract

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INDUSTRY NEWS

Karolinska Institute and Mayo Clinic Strengthen Their Cooperation
The scope of Karolinska Institute’s cooperation with one of the world’s leading health organizations, Mayo Clinic, is now being extended through a formal contract. [Karolinska Institute] Press Release

ViroPharma and Halozyme Therapeutics Announce Positive Data From Initial Phase II Assessment of Subcutaneous Cinryze® (C1 Esterase Inhibitor [human]) with Hyaluronidase
ViroPharma Incorporated and Halozyme Therapeutics announced positive data from ViroPharma’s open-label, multiple dose Phase II clinical trial designed to evaluate the safety, pharmacokinetics and pharmacodynamics of subcutaneous administration of Cinryze® in combination with Halozyme’s Enhanze™ technology in subjects with hereditary angioedema. [Halozyme Therapeutics, Inc.]
Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW Keystone Symposia on Molecular and Cellular Biology – Fibrosis: Translation of Basic Research to Human Disease and Novel Therapeutics
March 30 – April 4, 2012
Big Sky, United States


Visit our events page to see a complete list of events in the extracellular matrix community.
JOB OPPORTUNITIES

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Post-Doctoral/Research Scientist – (Mount Sinai School of Medicine)

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