Volume 2.47 | Dec 1

Extracellular Matrix News 2.47, December 1, 2011
     In this issue: PublicationsIndustry News | Policy News | Events | Jobs
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TOP STORY
Involvement of Perineuronal and Perisynaptic Extracellular Matrix in Alzheimer’s Disease Neuropathology
In this study researchers investigated extracellular matrix organization in primary sensory, secondary and associative areas of the temporal and occipital lobe. [Brain Pathol] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

CNT Reinforced Hybrid Microgels as Scaffold Materials for Cell Encapsulation
Here, researchers present reinforced CNT-gelatin methacrylate hybrid as a biocompatible, cell-responsive hydrogel platform for creating cell-laden three dimensional constructs. [ACS Nano] Abstract

BMP-2-Embedded Atelocollagen Scaffold for Tissue-Engineered Cartilage Cultured in the Medium Containing Insulin and Triiodothyronine – A New Protocol for Three Dimensional In Vitro Culture of Human Chondrocytes
Researchers examined the in vitro cartilage regeneration of tissue-engineered pellets that consisted of human auricular chondrocytes and atelocollagen, and that were incubated in vitro under the stimulation with BMP-2, insulin and triiodothyronine. [Tissue Eng Part C Methods] Abstract

Dystroglycan Promotes Filopodial Formation and Process Branching in Differentiating Oligodendroglia
In the current study researchers report that the extracellular matrix receptor dystroglycan is necessary for laminin enhancement of filopodial formation, process outgrowth, and process branching in differentiating oligodendroglia. [J Neurochem] Abstract

Increased Matrix Synthesis by Fibroblasts with Decreased Proliferation on Synthetic Chitosan-Gelatin Porous Structures
Researchers investigated the influence of porous structures, hydrogels and membranes on the growth of normal human fibroblasts and their matrix production in a serum-free system. [Biotechnol Bioeng] Abstract

Cartilage Oligomeric Matrix Protein Enhances Matrix Assembly during Chondrogenesis of Human Mesenchymal Stem Cells
To test the hypothesis that cartilage oligomeric matrix protein/thrombospondin-5 (COMP/TSP5) functions in the assembly of the extracellular matrix during cartilage morphogenesis, researchers have employed mesenchymal stem cell chondrogenesis in vitro as a model to examine the effects of COMP over-expression on neo-cartilage formation. [J Cell Biochem] Abstract

Biophysicochemical Evaluation of Chitosan-Hydroxyapatite-Marine Sponge Collagen Composite for Bone Tissue Engineering
Scientists’ observations suggest that novel chitosan-hydroxyapatite-marine sponge collagen composite scaffolds are promising biomaterials for matrix-based bone repair and bone augmentation. [J Biomed Mater Res A] Abstract


Topographic Characterization and Protein Quantification of Esophageal Basement Membrane for Scaffold Design Reference in Tissue Engineering
This study reports basement membrane’s basic topographic characters and quantification of structural and major proteins involving collagen IV, laminin, entactin, proteoglycans of porcine esophagus. [J Biomed Mater Res B Appl Biomater] Abstract

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INDUSTRY NEWS

Medical Engineering Pioneers’ Royal Prize
Two decades of world-leading medical engineering research and impact have been rewarded with the Queen’s Anniversary Prize, which is the country’s highest accolade for an academic institution. [University of Leeds] Press Release

Virginia Tech’s Rylander Wins National Biomedical Engineering Award
Biomedical engineer Marissa Nichole Rylander is the recipient of the 2012 Y.C. Fung Young Investigator Award. [EurekAlert!] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW Gordon Research Conferences: Biomineralization
August 12-17, 2012
New London, United States

Visit our events page to see a complete list of events in the extracellular matrix community.
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Post-Doctoral/Research Scientist – (Mount Sinai School of Medicine)

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