Volume 2.46 | Nov 24

Extracellular Matrix News 2.46, November 24, 2011
     In this issue: PublicationsIndustry News | Policy News | Events | Jobs
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Nucleus Pulposus Cells Synthesize a Functional Extracellular Matrix and Respond to Inflammatory Cytokine Challenge following Long-Term Agarose Culture
To investigate direct links between interleukin-1 beta (IL-1β) and biomechanical changes, mature agarose constructs were treated with IL-1β, and effects on biomechanical properties, extracellular matrix composition and mRNA levels were quantified. [Eur Cell Mater] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Human Myxomatous Mitral Valve Prolapse: Role of Bone Morphogenetic Protein 4 in Valvular Interstitial Cell Activation
Researchers aimed to characterize bone morphogenetic protein 4 as a cellular regulator of mitral valvular interstitial cell activation towards a pathologic synthetic phenotype and to analyze the cellular phenotypic changes and extracellular matrix reorganization associated with the development of myxomatous mitral valve prolapse. [J Cell Physiol] Abstract

Polymorphisms of Genes Involved in Extracellular Matrix Remodeling and Abdominal Aortic Aneurysm
Researchers performed a candidate gene association study of polymorphisms in genes coding matrix metalloproteinases (MMPs), tissue inhibitors of MMPs, and elastin in abdominal aortic aneurysm. [J Vasc Surg] Abstract

H-Ras Isoform Modulates Extracellular Matrix Synthesis, Proliferation and Migration in Fibroblasts
To assess the individual role of H-Ras oncogene in basal and transforming growth factor-β1-mediated extracellular matrix synthesis, proliferation and migration in fibroblasts, researchers analyzed these processes in embryonic fibroblasts obtained from H-Ras knockout mice. [Am J Physiol Cell Physiol] Abstract

Tailoring Material Properties of a Nanofibrous Extracellular Matrix Derived Hydrogel
In this study researchers aimed to examine and tailor the material properties of a self-assembling extracellular matrix hydrogel derived from porcine myocardial tissue, which was developed as a tissue specific injectable scaffold for cardiac tissue engineering. [Nanotechnology] Abstract

Extracellular Matrix Enhances Differentiation of Adipose Stem Cells from Infrapatellar Fat Pad toward Chondrogenesis
The objective of this study was to improve proliferation and chondrogenic potential of adipose stem cells (ASCs) by expansion on extracellular matrix deposited by either ASCs or synovium-derived stem cells. [J Tissue Eng Regen Med] Abstract

Development of the Zebrafish Myoseptum with Emphasis on the Myotendinous Junction
Using a series of zebrafish specimens aged between 24 h post-fertilization and 2 years old, the present paper describes at the transmission electron microscope level the development of extracellular and intracellular elements of the myotendinous junction. [Cell Tissue Res] Abstract

Biological Functionalization of Dental Implants with Collagen and Glycosaminoglycans – A Comparative Study
In the present study, researchers hypothesized that the coating of titanium implants with components of the organic extracellular matrix increases bone formation and implant stability compared to an uncoated reference. [J Biomed Mater Res B Appl Biomater] Abstract

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CorMatrix Receives Full IDE Approval for the Prospective, Randomized Evaluation of New Onset Postoperative Atrial Fibrillation in Patients Receiving the CorMatrix® ECM® for Pericardial Closure
CorMatrix Cardiovascular, Inc. announced that the U.S. Food and Drug Administration has granted the company full IDE approval for its ongoing multi-center, prospective, randomized clinical trial aiming to demonstrate the safety and efficacy of the CorMatrix extracellular matrix (ECM) for Pericardial Closure to reduce the incidence of new onset postoperative atrial fibrillation following isolated primary coronary artery bypass graft surgery. [PRNewswire] Press Release

NUI Galway PhD Graduate Awarded Prestigious European Doctoral Award
Dr Michael Keeney, a PhD graduate of National University of Ireland (NUI) Galway, has been awarded the prestigious European Doctoral Award for his PhD studies. [National University of Ireland, Galway]
Press Release


National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW The McGowan Institute for Regenerative Medicine – 7th Symposium on Biologic Scaffolds for Regenerative Medicine
April 26-28, 2012
Napa Valley, United States

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Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Post-Doctoral/Research Scientist – (Mount Sinai School of Medicine)

Post-Doctoral Positions (Finnish Centre of Excellence in Cell-Extracellular Matrix Research) 

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