Volume 2.43 | Nov 3

Extracellular Matrix News 2.43, November 3, 2011
     In this issue: PublicationsIndustry News | Policy News | Events | Jobs
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TOP STORY
Engineering Pro-Angiogenic Peptides Using Stable Disulfide-Rich Cyclic Scaffolds
Fragments from the extracellular matrix proteins laminin and osteopontin, and a sequence from VEGF, have potent proangiogenic activity despite their small size (< 10 residues). Here researchers show that the therapeutic potential of these peptides can be significantly improved by “grafting” them into cyclic peptide scaffolds. [Blood] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Epimorphin Promotes Human Hepatocellular Carcinoma Invasion and Metastasis through Activation of Focal Adhesion Kinase/Extracellular Signal-Regulated Kinase/Matrix Metalloproteinase-9 Axis
Researchers demonstrate that epimorphin, an extracellular protein, is strongly elevated in activated hepatic stellate cells within tumor stroma. [Hepatology] Abstract

Neural Cell Type-Specific Responses to Glycomimetic Functionalized Collagen
In this study, researchers have functionalized type I collagen with peptide mimics of two glycans: (1) polysialic acid and (2) an epitope first discovered on human natural killer cells. [Biomaterials] Abstract

Glycosaminoglycans from Aged Human Hippocampus Have Altered Capacities to Regulate Trophic Factors Activities but Not Aβ42 Peptide Toxicity
Here, researchers studied levels and composition of glycosaminoglycans isolated from adult and aged human hippocampus and investigated if their changes can influence the function of important trophic factors and the Aβ42 peptide toxicity. [Neurobiol Aging] Abstract

Simultaneous Analysis of Heparan Sulfate, Chondroitin/Dermatan Sulfates and Hyaluronan Disaccharides by Glycoblotting-Assisted Sample Preparation Followed by Single-Step ZIC-HILIC Chromatography
The present work describes a novel analytical technique that enables high throughput cellular/tissue glycosaminoglycomics for all three families of uronic acid-containing glycosaminoglycans, hyaluronan, chondroitin sulfate/dermatan sulfate, and heparan sulfate. [Anal Chem] Abstract

Protein and Mineral Composition of Osteogenic Extracellular Matrix Constructs Generated with a Flow Perfusion Bioreactor
This study investigated the temporal composition of an osteogenic extracellular matrix construct generated by culturing mesenchymal stem cells in an electrospun biodegradable poly(ε-caprolactone) fiber mesh scaffold within a flow perfusion bioreactor. [Biomacromolecules] Abstract

Proteomic Analysis of Col11a1-Associated Protein Complexes
Extracellular matrix molecules and cellular proteins that were identified as interacting with the amino terminal domain of collagen alpha 1(XI) directly or indirectly, included proteoglycans, collagens, and matricellular molecules, some of which also play a role in fibrillogenesis, while others are known to function in the maintenance of tissue integrity. [Proteomics] Abstract

Enhanced Secretion of Tissue Inhibitor of Metalloproteinases-1 by Human Hypertrophic Scar Keratinocytes Could Contribute to Fibrosis
The findings of this study represent an important advance in understanding the role of keratinocytes as a direct potent modulator for matrix degradation and scar tissue remodeling, possibly through inactivation of matrix metalloproteinases (MMPs). [Burns] Abstract

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INDUSTRY NEWS

Halozyme Therapeutics Announces Data from Two Phase I Studies of PEGPH20 Demonstrating Targeting of Hyaluronan in Tumor Stroma
Halozyme Therapeutics, Inc., a biopharmaceutical company developing and commercializing products targeting the extracellular matrix for the diabetes, cancer, dermatology and drug delivery markets, announced clinical trial results related to Halozyme’s clinical stage drug, pegylated rHuPH20 (PEGPH20). [Halozyme Therapeutics, Inc.] Press Release

CCMTR Begins Collaboration with Wake Forest University Institute for Regenerative Medicine
NC State’s Center for Comparative Medicine and Translational Research (CCMTR) and the Institute for Regenerative Medicine at Wake Forest’s Baptist Medical Center are pooling resources in order to find safe and effective ways to use stem cells to regenerate damaged organs in people and pets. [North Carolina (NC) State University College of Veterinary Medicine]
Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW European Molecular Biology Laboratory Conference – Stem Cells in Cancer and Regenerative Medicine
Heidelberg, Germany
August 29-September 1, 2012

Visit our events page to see a complete list of events in the extracellular matrix community.

JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Quality Control Technologist – Cell Separation (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Post-Doctoral/Research Scientist – (Mount Sinai School of Medicine)

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