Volume 2.42 | Oct 27

Extracellular Matrix News 2.42, October 27, 2011
     In this issue: PublicationsIndustry News | Policy News | Events | Jobs
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TOP STORY
ATXN1 Protein Family and CIC Regulate Extracellular Matrix Remodeling and Lung Alveolarization
Researchers demonstrate a critical role of ATAXIN1 (ATXN1)/ATXN1-Like-Capicua (ATXN1L-CIC) complexes in extracellular matrix (ECM) remodeling during development and their potential roles in pathogenesis of disorders affecting ECM remodeling. [Dev Cell] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

A Hybrid Nanofiber Matrix to Control the Survival and Maturation of Brain Neurons
Researchers design a versatile test bed to study the extracellular matrix contribution in neuron development and the design of optimal neuronal scaffold biomaterials. [Biomaterials] Abstract

Cyclic Nucleotide Phosphodiesterase 1A: A Key Regulator of Cardiac Fibroblast Activation and Extracellular Matrix Remodeling in the Heart
The objective of this study was to define and characterize the specific phosphodiesterase isoform that is altered during cardiac fibroblast activation and functionally important for regulating myofibroblast activation and extracellular matrix synthesis. [Basic Res Cardiol] Abstract

Critical Role of Factor XIII in the Initial Stages of Carbon Tetrachloride-Induced Adult Liver Remodeling
Although it has been hypothesized that the formation factor XIII (FXIII)-mediated fibrin–fibronectin provisional matrix is a critical step for extracellular matrix remodeling, researchers show in an FXIII subunit A–deficient murine model of acute liver injury that the lack of FXIII subunit A did not interfere with collagen reconstruction and resolution after acute liver injury. [Am J Pathol] Abstract

Effect of Self-Assembled Nanofibrous Silk/Polycaprolactone Layer on the Osteoconductivity and Mechanical Properties of Biphasic Calcium Phosphate Scaffolds
The cytocompatibility of extracellular matrix-like composite scaffolds was investigated by studying the attachment, morphology, proliferation and bone-related gene expression of primary human bone-derived cells. [Acta Biomater] Abstract

Cardiomyocytes In Vitro Adhesion Is Actively Influenced by Biomimetic Synthetic Peptides for Cardiac Tissue Engineering
In this study, three synthetic fragments of fibronectin, vitronectin and stromal-derived factor-1 were investigated for the first time as potential adhesive sequences for cardiomyocytes compared to smooth muscle cells. [Tissue Eng Part A] Abstract

Inhibition of TGF-β Signaling and Decreased Apoptosis in IUGR-Associated Lung Disease in Rats
Researchers investigated the effects of intrauterine growth restriction (IUGR) on lung function, expression of extracellular matrix components and transforming growth factor (TGF)-β signaling in rats. [PLoS One] Abstract

Right Ventricular Outflow Tract Repair with a Cardiac Biologic Scaffold
In this study, a porcine cardiac-extracellular matrix patch or Dacron patch was used to reconstruct a full-thickness right ventricular outflow tract defect in a rat model with end points of structural remodeling function at 16 weeks. [Cells Tissues Organs] Abstract

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INDUSTRY NEWS

Halozyme Announces Positive Results From Phase II Ultrafast Insulin Trials in Patients with Type 1 and Type II Diabetes
Halozyme Therapeutics, Inc., a biopharmaceutical company developing and commercializing products targeting the extracellular matrix for the diabetes, cancer, dermatology and drug delivery markets, announced positive results from two Phase II clinical trials of its ultrafast PH20 insulin analog formulations in patients with Type 1 and Type II diabetes. [Halozyme Therapeutics, Inc.] Press Release

Cell Biologist Chris A. Kaiser to Lead NIH’s National Institute of General Medical Sciences
National Institutes of Health (NIH) announced the selection of Chris A. Kaiser, Ph.D., as the new director of the National Institute of General Medical Sciences. [National Institutes of Health] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Stem Cells USA & Regenerative Medicine Congress 
September 18-20, 2012 
Boston, United States 

Visit our events page to see a complete list of events in the extracellular matrix community.

JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Quality Control Technologist – Cell Separation (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Post-Doctoral Research Associate (Tina Izard Lab) – Cancer Biology (Scripps Florida)

Lead Scientist – Tissue Engineering and Biomaterials (National Institutes of Health / Geneva Foundation)

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