Volume 2.41 | Oct 20

Extracellular Matrix News 2.41, October 20, 2011
     In this issue: PublicationsIndustry News | Policy News | Events | Jobs
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TOP STORY
A Syndecan-4 Hair Trigger Initiates Wound Healing through Caveolin- and RhoG-Regulated Integrin Endocytosis
Using atomic force microscopy, researchers have measured cell avidity for fibronectin and defined a mechanism for the outside-in regulation of a5ß1-integrin. [Dev Cell] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Adipose Tissue Extracellular Matrix and Vascular Abnormalities in Obesity and Insulin Resistance
This study was intended to better characterize the extracellular matrix and vascularity of insulin-resistant adipose tissue. [J Clin Endocrinol Metab] Abstract

Human sLZIP Induces Migration and Invasion of Cervical Cancer Cells via Expression of Matrix Metalloproteinase-9
In this study, researchers investigated the role of sLZIP in matrix metalloproteinase-9 expression and its involvement in cervical cancer development. [J Biol Chem] Abstract

FosB Regulates Stretch-Induced Expression of Extracellular Matrix Proteins in Smooth Muscle
Researchers identify a novel role for the AP-1 subunit FosB in stretch-induced extracellular matrix expression in smooth muscle cells. [Am J Pathol] Abstract

Collective Epithelial Cell Invasion Overcomes Mechanical Barriers of Collagenous Extracellular Matrix by a Narrow Tube-Like Geometry and Matrix Metalloproteinase 14-Dependent Local Softening
Researchers identified two strategies utilized by mammary epithelial cells that can independently minimize extracellular matrix mechanical resistance during collective cell invasion. [Integr Biol] Abstract

Heparan Sulfate Affects Elastin Deposition in Fibroblasts Cultured from Donors of Different Ages
Using two different in vitro experimental models, researchers investigated the role of heparan sulfate on elastin deposition and assembly. [Rejuvenation Res] Abstract

Mechanical Forces-Induced Human Osteoblasts Differentiation Involves MMP-2/MMP-13/MT1-MMP Proteolytic Cascade
In this study, researchers investigated the contribution of both proteolytic cascades, matrix metalloproteinase (MMP)-3/MMP-1 and MMP-2/MMP-13/MT1-MMP in the differentiation of human osteoblasts cultured in a floating type I collagen lattice versus an attached-collagen lattice. [J Cell Biochem] Abstract

In Vitro Influence of the Extracellular Matrix in Myoepithelial Cells Stimulated by Malignant Conditioned Medium
Researchers performed a study towards the effect of different extracellular matrix proteins (basement membrane matrix, type I collagen and fibronectin) on morphology and differentiation of benign myoepithelial cells from pleomorphic adenoma cultured with malignant cell culture medium from squamous cell carcinoma. [Oral Oncol] Abstract

Characterization of the Natural History of Extracellular Matrix Production in Tissue-Engineered Vascular Grafts during Neovessel Formation
In this study, researchers conclude that extracellular matrix (ECM) production during neovessel formation is characterized by early ECM deposition followed by extensive remodeling. [Cells Tissues Organs] Abstract

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INDUSTRY NEWS

New Swedish Fellowship Program Aims to Give Young Researchers a Leg Up
The Wallenberg Academy Fellows program, announced by the Knut and Alice Wallenberg Foundation in Stockholm, will give generous start-up funds and access to positions in Swedish universities to 125 grantees over the next 5 years. [ScienceInsider] Press Release

Cell Biologist Chris A. Kaiser to Lead NIH’s National Institute of General Medical Sciences
National Institutes of Health (NIH) Director Francis S. Collins, M.D., Ph.D., announced the selection of Chris A. Kaiser, Ph.D., as the new director of the National Institute of General Medical Sciences. [National Institutes of Health] Press Release 

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW International Society for Cellular Therapy 
June 5-8, 2012 
Seattle, United States 

Visit our events page to see a complete list of events in the extracellular matrix community.

JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Quality Control Technologist – Cell Separation (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Post-Doctoral Research Associate (Tina Izard Lab) – Cancer Biology (Scripps Florida)

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