Volume 2.40 | Oct 13

Extracellular Matrix News 2.40, October 13, 2011
     In this issue: PublicationsIndustry News | Policy News | Events | Jobs
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TOP STORY
Lack of Tissue Inhibitor of Metalloproteinases 2 (TIMP2) Leads to Exacerbated Left Ventricular Dysfunction and Adverse Extracellular Matrix (ECM) Remodeling in Response to Biomechanical Stress
Lack of TIMP2 leads to exacerbated cardiac dysfunction and remodeling after pressure overload because of excess activity of membrane type matrix metalloproteinase and loss of integrin β1D, leading to nonuniform ECM remodeling and impaired myocyte–ECM interaction. [Circulation] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Artificial Niche Microarrays for Probing Single Stem Cell Fate in High Throughput
Researchers report a microengineered platform comprised of soft hydrogel microwell arrays with modular stiffness (shear moduli of 1–50 kPa) in which individual microwells can be functionalized with combinations of proteins spotted by robotic technology. To validate the platform, researchers tested the effect of cell-cell interactions on adipogenic differentiation of adherent human mesenchymal stem cells (MSCs) and the effect of substrate stiffness on osteogenic MSC differentiation. [Nat Methods] Abstract | Press Release

Sympathetic Control of Bone Mass Regulated by Osteopontin
Using cell-based and murine genetics approaches, researchers show that this activity of the sympathetic nervous system requires osteopontin, a cytokine and one of the major members of the noncollagenous extracellular matrix proteins of bone. [Proc Natl Acad Sci USA] Abstract

Like-Acetylglucosaminyltransferase (LARGE)-Dependent Modification of Dystroglycan at Thr-317/319 is Required for Laminin Binding and Arenavirus Infection
Because the N-terminal region adjacent to the paired Thr residues is removed during posttranslational maturation of dystroglycan, the results demonstrate that the ligand-binding activity resides at the extreme N terminus of mature α-dystroglycan and is crucial for α-dystroglycan to coordinate the assembly of extracellular matrix proteins and to bind arenaviruses on the cell surface. [Proc Natl Acad Sci USA] Abstract

Changes in the Chondrocyte and Extracellular Matrix Proteome during Post-Natal Mouse Cartilage Development
This first proteomic analysis of cartilage development in vivo reveals the breadth of protein expression changes during chondrocyte maturation and extracellular matrix remodeling in the mouse femoral head. [Mol Cell Proteomics] Abstract

The Effects of Acellular Amniotic Membrane Matrix on Osteogenic Differentiation and ERK1/2 Signaling in Human Dental Apical Papilla Cells
In this study, it was found that both basement membrane side and collagenous stroma side of the acellular amniotic membrane matrix were capable of providing a preferential environment for driving the osteogenic differentiation of human dental apical papilla cells with proven stem cell characteristics. [Biomaterials] Abstract

Spatial Arrangement of Polycaprolatonec/Collagen Nanofibrous Scaffolds Regulates the Wound-Healing Related Behaviors of Human Adipose Stromal Cells
This study on the expression of extracellular matrix (ECM) related genes in human adipose stromal cells revealed higher synthesis capacity for critical ECM molecules including tropoelastin, collagen I and matrix metalloproteinase (MMP)-1, on the aligned nanofibers. [Tissue Eng Part A] Abstract

Dynamic Compressive Loading Enhances Cartilage Matrix Synthesis and Distribution and Suppresses Hypertrophy in hMSC-Laden Hyaluronic Acid Hydrogels
In this study, researchers investigated the effect of dynamic compressive loading on chondrogenesis, the production and distribution of cartilage specific matrix, and the hypertrophic differentiation of human mesenchymal stem cells (MSCs) encapsulated in hyaluronic acid hydrogels during long term culture. [Tissue Eng Part A] Abstract

Engineering 3D Cell Instructive Microenvironments by Rational Assembly of Artificial Extracellular Matrices and Cell Patterning
In this work, researchers introduce a flexible strategy that relies on the combination of artificial extracellular matrices with patterning techniques as well as a layer-by-layer approach to mimic rationally-designed instructive milieus. [Integr Biol] Abstract

Diabetic Impairment of C-kit Bone Marrow Stem Cells Involves the Disorders of Inflammatory Factors, Cell Adhesion and Extracellular Matrix Molecules
Researchers investigated the mechanisms responsible for diabetes-related functional impairment of bone marrow stem cells by extensively screening the expression levels of inflammatory factors, cell cycle regulating molecules, extracellular matrix molecules and adhesion molecules. [PLoS ONE] Abstract

Colorectal Cancer Desmoplastic Reaction Up-Regulates Collagen Synthesis and Restricts Cancer Cell Invasion
In this study, researchers analyzed desmoplasia in vivo in human colorectal carcinoma tissue, detecting an up-regulation of collagen I, collagen IV and collagen V in human colorectal cancer desmoplastic reaction. [Cell Tissue Res] Abstract

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INDUSTRY NEWS

CorMatrix Receives Carotid Artery Repair Indication for its CorMatrix® ECM®
CorMatrix Cardiovascular, Inc., a medical device company dedicated to developing and delivering unique extracellular matrix (ECM) biomaterial devices that harness the body’s innate ability to repair damaged cardio-vascular tissue, announced that the U.S. Food and Drug Administration has granted the company 510(k) clearance to market its CorMatrix® ECM® for Carotid Repair, which utilizes the company’s proprietary ECM Technology. [PRNewswire] Press Release

New National Tissue Engineering Centre to Develop Treatment for Early Osteoarthritis
Arthritis Research UK launched a £6 million experimental tissue engineering centre which aims to regenerate bone and cartilage by using patients’ own stem cells to repair the joint damage caused by osteoarthritis. [Arthritis Research UK] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW American Association for Cancer Research: Translational Cancer Research for Basic Scientists
October 30-November 4, 2011
Boston, United States

Visit our events page to see a complete list of events in the extracellular matrix community.

JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Quality Control Technologist – Cell Separation (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Post-Doctoral Position: Extracellular Matrix and Tendon Development (Institut de Génomique Fonctionnelle de Lyon)

Post-Doctoral Research Associate (Tina Izard Lab) – Cancer Biology (Scripps Florida)

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