Volume 2.37 | Sep 22

Extracellular Matrix News 2.37, September 22, 2011
     In this issue: PublicationsIndustry News | Policy News | Events | Jobs
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Cultured Cell-Derived Extracellular Matrix Scaffolds for Tissue Engineering
In this study, extracellular matrix scaffolds derived from mesenchymal stem cells, chondrocytes, and fibroblasts were prepared by culturing cells in a selectively removable poly(lactic-co-glycolic acid) template. [Biomaterials] Abstract


PUBLICATIONS (Ranked by Impact Factor of the Journal)

Fibronectin- and Collagen-Mimetic Ligands Regulate Bone Marrow Stromal Cell Chondrogenesis in Three-Dimensional Hydrogels
This study aimed to determine whether collagen- and fibronectin-mimetic ligands would retain biologic functionality in three-dimensional hydrogels, whether different extracellular matrix-mimetic ligands differentially influence in vitro chondrogenesis, and if effects of ligands on differentiation depend on soluble biochemical stimuli. [Eur Cell Mater] Abstract

Long Term Performance of Polycaprolactone Vascular Grafts in a Rat Abdominal Aorta Replacement Model
In this study, polycaprolactone micro and nano-fiber based vascular grafts were evaluated in the rat abdominal aorta replacement model for 1.5, 3, 6, 12, and 18 months (n = 3 for each time point). [Biomaterials] Abstract

Two-Tier Hydrogel Degradation to Boost Endothelial Cell Morphogenesis
Cell-responsive degradation of biofunctional scaffold materials is required in many tissue engineering strategies and commonly achieved by the incorporation of protease-sensitive oligopeptide units. In extension of this approach, researchers combined protease-sensitive and -insensitive cleavage sites for the far-reaching control over degradation rates of starPEG-heparin hydrogel networks with orthogonally modulated elasticity, RGD presentation and VEGF delivery. [Biomaterials] Abstract

Enhancing Cell Penetration and Proliferation in Chitosan Hydrogels for Tissue Engineering Applications
The aim of this study was to develop a process to create highly porous three-dimensional chitosan hydrogels suitable for tissue engineering applications. [Biomaterials] Abstract

Porcine Small Diameter Arterial Extracellular Matrix Supports Endothelium Formation and Media Remodeling Forming a Promising Vascular Engineered Biograft
The findings indicate the potential of such decellularized arterial extracellular matrix for future small caliber vascular graft reconstruction therapies. [Tissue Eng Part A] Abstract

A Dual Regulation of Breast Tubulogenesis by Extracellular Matrix Composition and Stromal Cells
Here, researchers used a 3-dimensional in vitro culture to study the roles of stromal cells and extracellular matrix components during mammary tubulogenesis. [Tissue Eng Part A] Abstract

Evaluation of a Thin and Mechanically Stable Collagen Cell Carrier
In the present study, researchers evaluated the mechanical and the cell biological properties of a novel, thin, and planar collagen scaffold. [Tissue Eng Part C] Abstract

MMP Mediated Degradation of Type VI Collagen Is Highly Associated with Liver Fibrosis – Identification and Validation of a Novel Biochemical Marker Assay
The aim of this study was to develop an ELISA detecting a fragment of type VI collagen generated by matrix metalloproteinase (MMP)-2 and MMP-9, and evaluate this assay in two preclinical models of liver fibrosis. [PLoS ONE] Abstract

Cone Outer Segment Extracellular Matrix as Binding Domain for Interphotoreceptor Retinoid-Binding Protein (IRBP)
Here, researchers explore the association of IRBP with the interphotoreceptor matrix of cones versus rods in cone dominant retinas from chicken (Gallus domesticus), turkey (Meleagris gallopavo), and pig (Sus scrofa). [J Comp Neurol] Abstract

Engineering the Growth Factor Microenvironment with Fibronectin Domains to Promote Wound and Bone Tissue Healing
Researchers present an approach for engineering the cellular microenvironment to greatly accentuate the effects of vascular endothelial growth factor–A and platelet-derived growth factor–BB (PDGF-BB) for skin repair, and of bone morphogenetic protein–2 and PDGF-BB for bone repair. [Sci Transl Med] Abstract



Halozyme Therapeutics to Present at the JMP Securities Healthcare Conference on September 28
Halozyme Therapeutics, Inc., a biopharmaceutical company developing and commercializing products targeting the extracellular matrix, announced that management will be presenting at the JMP Securities Healthcare Conference in New York. [Halozyme Therapeutics, Inc.] Press Release

AACR Releases Landmark Cancer Progress Report
The American Association for Cancer Research (AACR) unveiled the AACR Cancer Progress Report 2011 during a press conference at the National Press Club in Washington, D.C. [American Association for Cancer Research] Press Release


National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


NEW 2011 Bioreactor & Growth Environments for Tissue Engineering Training Course
November 14-16, 2011
Keele, United Kingdom

Visit our events page to see a complete list of events in the extracellular matrix community.


Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Research and Development Technologist (STEMCELL Technologies)

Post-Doctoral Position: Extracellular Matrix and Tendon Development (Institut de Génomique Fonctionnelle de Lyon)

Post-Doctoral Research Associate (Tina Izard Lab) – Cancer Biology (Scripps Florida)

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