Volume 2.32 | Aug 18

Extracellular Matrix News 2.32, August 18, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
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TOP STORY

Engineering Extracellular Matrix Structure in 3D Multiphase Tissues
In this paper, researchers demonstrate a method to engineer local variations in the density and size of collagen fibers throughout 3D tissues. [Biomaterials]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Lysyl Oxidase-Like Protein-2 Regulates Sprouting Angiogenesis and Type IV Collagen Assembly in the Endothelial Basement Membrane
Researchers performed a proteomic analysis of extracellular matrix from endothelial cells maintained in hypoxia, a major stimulator of angiogenesis. [Blood]

Hyperphosphorylation of Mouse Cardiac Titin Contributes to Transverse Aortic Constriction-Induced Diastolic Dysfunction
Transverse aortic constriction-induced heart failure results in increased extracellular matrix-based and titin-based passive stiffness. [Circ Res]

The Inhibition of Infection by Wound Pathogens on Scaffold in Tissue-Forming Process Using N-Acetyl Cysteine
This in vitro study evaluated whether N-acetyl cysteine prevented bacterial infection of gingival fibroblasts and osteoblasts on a scaffold. [Biomaterials]

Low Carotid Calcium Score Is Associated With Higher Levels of Glycosaminoglycans, Tumor Necrosis Factor-Alpha, and Parathyroid Hormone in Human Carotid Plaques
This study assesses the relation between carotid calcium score by computed tomography and plaque composition, namely extracellular matrix, inflammatory mediators, and calcium metabolites. [Stroke]

Immobilizing Reporters for Molecular Imaging of the Extracellular Microenvironment in Living Animals
Researchers report here an immobilization strategy using a collagen binding protein to deliver and confine synthetic reporters to the extracellular microenvironment in vivo for non-invasively imaging the activity of targets in the microenvironment. [ACS Chem Biol]

Using Self-Assembled Monolayers To Understand α8β1-Mediated Cell Adhesion to RGD and FEI Motifs in Nephronectin
This paper describes the use of self-assembled monolayers to study the adhesion of α8β1-presenting cells to the RGD and DLFEIFEIER ligands in nephronectin and found that both ligands can independently mediate cell adhesion through nonoverlapping binding sites on the integrin. [ACS Chem Biol]

Peculiarities of the Extracellular Matrix in the Interstitium of the Renal Stem/Progenitor Cell Niche
The applied technique appears to be a suitable method to illuminate the interstitium in stem/progenitor cell niches of specialized tissues, the microenvironment of tumors and extension of degeneration. [Histochem Cell Biol]

Pulmonary Fibroblasts Mobilize the Membrane-Tethered Matrix Metalloprotease, MT1-MMP, to Destructively Remodel and Invade Interstitial Type I Collagen Barriers
Herein, membrane type-1 matrix metalloprotease (MT1-MMP) is identified as the dominant, and direct-acting, protease responsible for the type I collagenolytic activity mediated by both mouse and human pulmonary fibroblasts. [Am J Physiol Lung Cell Mol Physiol]

Extracellular Matrix (ECM) Molecules Implicated in Hypertrophic and Keloid Scarring
To summarize what is known about the expression and composition of ECM molecules in abnormal scarring, an extensive search of the literature was conducted, focusing on keywords connected to skin scarring, hypertrophic scars and keloid disease. The transcription and translation of collagen I and III, fibronectin, laminin, periostin and tenascin are all increased in raised dermal scar tissue. [J Eur Acad Dermatol Venereol]

ECM-Based Triple Layered Scaffolds for Vascular Tissue Engineering
The present study focused on the development of three layered small-diameter (<6 mm) extracellular matrix (ECM)-based vessels. These were engineered artificially through the freeze-drying technique. [Int J Mol Med]

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INDUSTRY NEWS

Kensey Nash Reports Fourth Quarter and Full Fiscal Year 2011 Financial Results
Kensey Nash Corporation, a medical device company primarily focused on regenerative medicine for a wide range of medical procedures, reported the results for its fourth quarter and fiscal year ended June 30, 2011. [Kensey Nash Corporation Press Release]

GHSU Launches New Institute for Regenerative and Reparative Medicine
A new Institute for Regenerative and Reparative Medicine is working to help the body repair itself as it grows synergy between Georgia Health Sciences University (GHSU) and the community. [Georgia Health Sciences University Press Release]

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW International Society for Cellular Therapy: BMCOGS & Reimbursement Roundtable
September 14, 2011
Minneapolis, United States

JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)
                               

Research and Development Technologist (STEMCELL Technologies)             


Extracellular Matrix Protein Study (Università degli Studi di Genova)

Integrable Systems, Matrix Models and Asymptotics Fellowship (Scuola Superiore Internazionale di Studi Avanzati)

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