Volume 2.31 | Aug 11

Extracellular Matrix News 2.31, August 11, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
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TOP STORY
Extracellular Matrix Structure and Nano-Mechanics Determine Megakaryocyte Function
In this work researchers focus on the regulation of megakaryocyte development by type I collagen. [Blood]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Effects of Hypoxias and Scaffold Architecture on Rabbit Mesenchymal Stem Cell Differentiation towards a Nucleus Pulposus-Like Phenotype
The data showed the promise of using 3D nanofibrous scaffolds in combination with TGF-β1 and hypoxic induction to regenerate functional nucleus pulposus grafts for intervertebral disc replacement. [Biomaterials]

Mechanical and Biological Properties of Keratose Biomaterials
The degraded keratose was observed to remodel with the natural collagen extracellular matrix, verifying the benefit of using keratose as a temporary matrix for regenerative medicine applications. [Biomaterials]

Elucidating the Mechanobiology of Malignant Brain Tumors Using a Brain Matrix-Mimetic Hyaluronic Acid Hydrogel Platform
Researchers synthesized brain-mimetic extracellular matrices based on hyaluronic acid with a range of stiffnesses that encompasses normal and tumorigenic brain tissue and functionalized these materials with short Arg-Gly-Asp (RGD) peptides to facilitate cell adhesion. [Biomaterials]

Influence of Chondroitin Sulfate and Hyaluronic Acid on Structure, Mechanical Properties, and Glioma Invasion of Collagen I Gels
To mimic the extracellular matrix surrounding high grade gliomas, composite matrices composed of either acid-solubilized or pepsin-treated collagen and the glycosaminoglycans chondroitin sulfate and hyaluronic acid are prepared and characterized. [Biomaterials]

Bioprinting of Growth Factors Onto Aligned Sub-Micron Fibrous Scaffolds for Simultaneous Control of Cell Differentiation and Alignment
Herein, oriented sub-micron fibers, which are morphologically similar to musculoskeletal extracellular matrix, were spatially patterned with growth factors using an inkjet-based bioprinter to create geometric and biochemical cues that direct musculoskeletal cell alignment and differentiation in vitro in registration with fiber orientation and printed patterns, respectively. [Biomaterials]

Regeneration of Uterine Horns in Rats by Collagen Scaffolds Loaded with Collagen-Binding Human Basic Fibroblast Growth Factor
In the present study, a collagen targeting basic fibroblast growth factor (bFGF) delivery system was constructed by a collagen membrane loaded with bFGF fused a collagen-binding domain to the N-terminal which limits the diffusion of bFGF from collagen. [Biomaterials]

Artificial Extracellular Matrix Proteins Containing Phenylalanine Analogues Biosynthesized in Bacteria Using T7 Expression System and the PEGlyation
In vivo incorporation of the phenylalanine analogues into an artificial extracellular matrix protein (aECM-CS5-ELF) was accomplished by using a bacterial expression host that harbors a mutant phenylalanyl-tRNA synthetase with an enlarged binding pocket. [Biomacromolecules]

Peculiarities of the Extracellular Matrix in the Interstitium of the Renal Stem/Progenitor Cell Niche
The applied technique appears to be a suitable method to illuminate the interstitium in stem/progenitor cell niches of specialized tissues, the microenvironment of tumors and extension of degeneration. [Histochem Cell Biol]

Overexpression of HTRA1 Leads to Ultrastructural Changes in the Elastic Layer of Bruch’s Membrane via Cleavage of Extracellular Matrix Components
The data implicate that HTRA1 overexpression leads to an altered elastogenesis in Bruch’s membrane through fibulin 5 cleavage. It highlights the importance of extracellular matrix related proteins in the development of age-related macular degeneration (AMD) and links HTRA1 to other AMD risk genes such as fibulin 5, fibulin 6, ARMS2 and TIMP3. [PLoS ONE]

Human Mesenchymal Stem Cells Seeded on Extracellular Matrix Scaffold: Viability and Osteogenic Potential
A new combination between cells and ECM-scaffold, containing extracellular matrix (ECM) has here been analyzed. [J Cell Physiol]

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INDUSTRY NEWS

Halozyme Therapeutics Reports Second Quarter 2011 Financial Results
Halozyme Therapeutics, Inc., a biopharmaceutical company developing and commercializing products targeting the extracellular matrix for the diabetes, cancer, dermatology and drug delivery markets, reported financial results for the second quarter of 2011 and discussed recent business progress. [Halozyme Therapeutics, Inc. Press Release]

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW Scaffolding in Regenerative Medicine
September 12, 2011
Webinar
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Extracellular Matrix Protein Study (Università degli Studi di Genova)

Integrable Systems, Matrix Models and Asymptotics Fellowship (Scuola Superiore Internazionale di Studi Avanzati)

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