Volume 2.27 | Jul 14

Extracellular Matrix News 2.27, July 14, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
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TOP STORY
Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis
Researchers show that caveolin-1 favors cell elongation in three-dimensional cultures and promotes Rho- and force-dependent contraction, matrix alignment, and microenvironment stiffening through regulation of p190RhoGAP. [Cell]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Conducting Polymers with Immobilized Fibrillar Collagen for Enhanced Neural Interfacing
This study demonstrates that the direct coupling of extracellular matrix components such as collagen, followed by their further self-assembly into three-dimensional matrices, has the potential to improve the neural-electrode interface of implant electrodes by encouraging nerve cell attachment and differentiation. [Biomaterials]

Characterization of Early Extracellular Matrix Secretions in a Three-Dimensional Thixotropic Cell Culture System
In this current study, researchers developed a thixotropic polymer-silica nanocomposite gel that may be used to characterize the extracellular matrix secretions of cells cultured in a three-dimensional environment. [Acta Biomater]

Expansion on Extracellular Matrix Deposited by Human Bone Marrow Stromal Cells Facilitates Stem Cell Proliferation and Tissue-Specific Lineage Potential
In this study, researchers assess the rejuvenation effect of extracellular matrix deposited by human bone marrow stromal cells (hBMSCs) on hBMSC expansion and tissue-specific lineage differentiation potential. [Tissue Eng Part A]

The Feelgood Mutation in Zebrafish Dysregulates COPII-Dependent Secretion of Select Extracellular Matrix Proteins in Skeletal Morphogenesis
Researchers demonstrate that the zebrafish feelgood mutation causes a single amino acid substitution within the DNA-binding domain of transcription factor Creb3l2. [Dis Model Mech]

L-Carnosine Inhibits High-Glucose-Mediated Matrix Accumulation in Human Mesangial Cells by Interfering with TGF-β Production and Signaling
In this present study, researchers tested the hypothesis that L-carnosine inhibits TGF-β production and signaling, thereby reducing hyperglycemia-associated extracellular matrix accumulation. [Nephrol Dial Transplant]

Large Proteoglycan Complexes and Disturbed Collagen Architecture in the Corneal Extracellular Matrix of Mucopolysaccharidosis Type VII (Sly Syndrome)
In this study, researchers analyze novel pathologic changes in Sly Syndrome to determine the nature of proteoglycan-collagen associations in stromal ultrastructure. [Invest Ophthalmol Vis Sci]

Extracellular Matrix Fluctuations during Early Embryogenesis
Researchers show that the extracellular matrix moves as a composite material, whereby distinct molecular components as well as spatially separated layers exhibit similar displacements. [Phys Biol]

Extracellular Matrix Metalloproteinase as a Novel Target for Pancreatic Cancer Therapy
The objective of this study was to evaluate extracellular matrix metalloproteinase as a novel target in orthotopic pancreatic cancer murine models. [Anticancer Drugs]

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INDUSTRY NEWS
Baxter and Halozyme Announce Top-Line Results of Phase III Study of HyQ in Patients with Primary Immunodeficiency
Baxter International Inc. and Halozyme Therapeutics announced top-line results of a phase III study of HyQ, an investigational facilitated subcutaneous immune globulin product for use in patients with primary immunodeficiency. [Halozyme Therapeutics Inc., Press Release]

Researchers Receive Grants from NCCN Oncology Research Program Funded Through Pfizer
The National Comprehensive Cancer Network (NCCN) Oncology Research Program received $2.1 million in research funding from Pfizer, Inc. to support research at NCCN Member Institutions in order to gain further insight into the use of axitinib in various tumor types. [National Comprehensive Cancer Network Press Release]
POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Cancer Research Global Summit 
August 16-17, 2011 
London, United Kingdom


NEW Stem Cell Society Singapore Symposium 2011 
November 17-18, 2011 
Singapore, Singapore

JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Extracellular Matrix Protein Study (Università degli Studi di Genova)

Research Associate in Synthetic Biology (Institute of Systems and Synthetic Biology)


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