Volume 2.26 | Jul 7

Extracellular Matrix News 2.26, July 7, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
Cell Therapy News on Facebook  Extracellular Matrix News on Twitter
TOP STORY
Three-Dimensional Culture of Hepatocytes on Porcine Liver Tissue-Derived Extracellular Matrix
The goal of this study was to investigate whether three-dimensional extracellular matrix derived from porcine liver can facilitate the growth and maintenance of physiological functions of liver cells. [Biomaterials]

ON118-NeuralAdherent_645x110_Video
CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Severe Lung Fibrosis Requires an Invasive Fibroblast Phenotype Regulated by Hyaluronan and CD44
Researchers found that targeted overexpression of hyaluronan synthase 2 by myofibroblasts produced an aggressive phenotype leading to severe lung fibrosis and death after bleomycin-induced injury. [J Exp Med]

The Effect of Stromal Components on the Modulation of the Phenotype of Human Bronchial Epithelial Cells in Three Dimensional Culture
Researchers suggest that lung cancer-associated fibroblasts may alter the human bronchial epithelial cell phenotype by modifying biomechanical signals conveyed through the extracellular matrix. [Biomaterials]

Engineering Articular Cartilage with Spatially-Varying Matrix Composition and Mechanical Properties from a Single Stem Cell Population Using a Multi-Layered Hydrogel
In this current study, researchers demonstrate that layer-by-layer organization of specific biomaterial compositions creates three dimensional niches that allow a single mesenchymal stem cell population to differentiate into zone-specific chondrocytes and organize into a complex tissue structure. [Biomaterials]

EMMPRIN and Its Ligand Cyclophilin A as Novel Diagnostic Markers in Inflammatory Cardiomyopathy
The aim of the present study was to investigate whether the extracellular matrix metalloproteinase inducer (EMMPRIN) and its ligand Cyclophilin A are upregulated in inflammatory cardiomyopathy and may serve as diagnostic markers. [Int J Cardiol]

Okadaic Acid Induces MMP-9 Expression in Fibroblast: Crosstalk between Protein Phosphatase Inhibition and β-Adrenoceptor Signaling
Researchers investigated the effect of okadaic acid on matrix metalloproteinase-9 (MMP-9) expression, and assessed the interplay between phosphatase inhibition and β-adrenoceptor signaling in fibroblasts. [Br J Pharmacol]

Carcinoma Matrix Controls Resistance to Cisplatin through Talin Regulation of NF-kB
This study focused on understanding matrix adhesion pathways that control the oral carcinoma response to cisplatin. [PLoS One]

The Long Polar Fimbriae of Enterohemorrhagic Escherichia Coli 0157:H7 Binds to Extracellular Matrix Proteins
Researchers suggest that the interaction of long polar fimbriae and extracellular matrix proteins contributes to enterohemorrhagic Escherichia coli colonization of the gastrointestinal tract. [Infect Immun]

Thermoresponsive Poly(N-Isopropylacrylamide)-G-Methylcellulose Hydrogel as a Three-Dimensional Extracellular Matrix for Cartilage-Engineered Applications
The aim of this work is to explore the ability of poly(N-isopropylacrylamide)-g-methylcellulose thermoreversible hydrogel as a three-dimensional support for cell encapsulation toward the regeneration of articular cartilage through a tissue engineering approach. [J Biomed Mater Res A]

Neomycin Enhances Extracellular Matrix Stability of Glutaraldehyde Crosslinked Bioprosthetic Heart Valves
In this study, researchers examined the ability of neomycin to enhance glutaraldehyde crosslinking to stabilize glycosaminoglycans, as well as provide evidence of improved functional integrity. [J Biomed Mater Res B Appl Biomater]

RSGRoboSep_645x110-WatchVid

INDUSTRY NEWS

Scripps Institutions Join National Tumor Consortium
The Scripps Research Institute, Scripps Health, and Scripps Translational Science Institute have announced they have joined a national consortium of research institutions headed by The Jackson Laboratory that is building a library of primary human tumors with the goal of developing highly targeted cancer therapies. [Scripps Research Press Release]

Halozyme’s Ultrafast Insulin Demonstrates Reduced Variability of Insulin Absorption for Type 1 Diabetes Patients Using Insulin Pumps
Halozyme Therapeutics, Inc. announced final results from a study in type 1 diabetes patients who receive their insulin treatment with a pump demonstrating that Aspart-PH20, a formulation of Halozyme’s recombinant human hyaluronidase with the active ingredient in NovoLog®, reduces the variability of insulin absorption and reduces post-meal glycemic excursions compared to NovoLog alone. [Halozyme Therapeutics Inc., Press Release]

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW The American Society of Clinical Oncology and the American Association for Cancer Research: Methods in Clinical Cancer Research 
July 30-August 5, 2011 
Vail, United States
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Extracellular Matrix Protein Study (Università degli Studi di Genova)

Research Associate in Synthetic Biology (Institute of Systems and Synthetic Biology)


Recruit Top Talent
Reach more than 11,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Jobs are categorized regionally:
United States, Canada, Europe, Asia Pacific

Visit here to post your career opportunities.

Have we missed an important article or publication in Extracellular Matrix News? Click here to submit!

Comments or Suggestions? Email [email protected] with your feedback.

Learn more about Extracellular Matrix Cell News: Archives | Events | Contact Us