Volume 2.25 | Jun 30

Extracellular Matrix Cell News 2.25, June 30, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
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TOP STORY

Breast Cancer Cells Produce Tenascin C as a Metastatic Niche Component to Colonize the Lungs
The findings link tenascin C (TNC) to pathways that support the fitness of metastasis-initiating breast cancer cells and highlight the relevance of TNC as an extracellular matrix component of the metastatic niche.
[Nat Med]

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SCIENCE NEWS
Potential New Approaches to Treat Myelofibrosis
A new study sheds light on a possible new approach to treat the bone marrow disease known as myelofibrosis by inhibiting an enzyme that connects extracellular fibers. [Press release from ScienceDaily discussing online prepublication in the Journal of Biological Chemistry]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Matrix Metalloproteinase-9 Inhibition Reduces Inflammation and Improves Motility in Murine Models of Post-Operative Ileus
Researchers evaluated the role of matrix metalloproteinase-9 (MMP-9) in post-operative ileus (POI) and investigated whether disruption of MMP-9 or administration of an inhibitor of MMP-9 activity reduced cellular inflammation and bowel dysmotility in rat and mouse models of POI. [Gastroenterology]

The Effect of Composition of Calcium Phosphate Composite Scaffolds on the Formation of Tooth Tissue from Human Dental Pulp Stem Cells
In the present study, researchers tested biocompatibility of four different types of 3-D scaffolds for tooth-tissue regeneration, including a pure poly(lactide-co-glycolide) scaffold and three types of calcium phosphate contained composites scaffolds. [Biomaterials]

MMP-9 from Sublethally Irradiated Tumor Promotes Lewis Lung Carcinoma Cell Invasiveness and Pulmonary Metastasis
Researchers sought to investigate the role of matrix metalloproteinase-9 (MMP-9) from sublethally irradiated tumor in accelerated pulmonary metastasis of Lewis lung carcinoma and the corresponding anti-metastasis strategies in C57BL/6 mice. [Oncogene]

The Transcriptional Regulator Megakaryoblastic Leukemia-1 Mediates Serum Response Factor-Independent Activation of Tenascin-C Transcription by Mechanical Stress
Researchers demonstrate that overexpression of megakaryoblastic leukemia-1 strongly induces tenascin-C expression in mouse NIH3T3 fibroblasts and normal HC11 and transformed 4T1 mammary epithelial cells. [FASEB J]

Control of Megakaryocyte Expansion and Bone Marrow Fibrosis by Lysyl Oxidase
Researchers examined the expression and functions of lysyl oxidase in megakaryocytes, the platelet precursors. [J Biol Chem]

MMP-2/MMP-9 Plasma Level and Brain Expression in Cerebral Amyloid Angiopathy-Associated Hemorrhagic Stroke
In this study, researchers determined the levels of matrix metalloproteinase-2 (MMP-2) and MMP-9 in plasma and their brain expression in cerebral amyloid angiopathy-associated hemorrhagic stroke. [Brain Pathol]

TGF-β3 Stimulates Cartilage Matrix Elaboration by Human Marrow-Derived Stromal Cells Encapsulated in Photocrosslinked Carboxymethylcellulose Hydrogels: Potential for Nucleus Pulposus Replacement
The results demonstrate that human marrow-derived stromal cells encapsulated in photocrosslinked carboxymethylcellulose hydrogels supplemented with transforming growth factor-β3 (TGF-β3) are capable of elaborating functional extracellular matrix consistent with the nucleus pulposus phenotype. [Tissue Eng Part A]

The Effect of Mesenchymal Stromal Cell-Hyaluronic Acid Hydrogel Constructs on Immunophenotype of Macrophages
Researchers investigated the effect of mesenchymal stromal cells on immunophenotype of macrophages in the presence of an hyaluronic acid–hydrogel scaffold using a unique 3D coculture system. [Tissue Eng Part A]

The Type II Collagen N-Propeptide, PIIBNP, Inhibits Cell Survival and Bone Resorption of Osteoclasts via Integrin-Mediated Signaling
Researchers undertook in vitro and in vivo experiments to evaluate both osteoblast and osteoclast functions in the presence of recombinant type IIB procollagen NH2-propeptide (PIIBNP). [Bone]

Dual Targeting of EGFR and Focal Adhesion Kinase in 3D Grown HNSCC Cell Cultures
To examine effects of dual epidermal growth factor (EGFR)/focal adhesion kinase (FAK) inhibition on cellular radiosensitivity of head and neck squamous cell carcinoma (HNSCC) cells in a more physiological environment, researchers employed a previously established laminin-rich extracellular matrix based three-dimensional cell culture model. [Radiother Oncol]

Elevated MMP-7 Levels in Patients with Systemic Sclerosis: Correlation with Pulmonary Involvement
Researchers investigated whether serum matrix metalloproteinase-7 (MMP-7) levels reflect the activity of the fibrotic reaction in systemic sclerosis. [Exp Dermatol]

INDUSTRY NEWS

UC Davis Clinical and Translational Science Center Receives Renewed Grant Funding
The University of California (UC) Davis Clinical and Translational Science Center received renewed grant funding of $20 million from the National Center for Research Resources. [University of California, Davis Press Release]

Leaders in Fight Against Cancer Join Historic Initiative Addressing Clinical Investigator Shortage
The Damon Runyon Cancer Research Foundation announced the formation of Accelerating Cancer Cures, a historic collaboration of the biopharmaceutical industry and academia with a strong commitment to achieving key breakthroughs in cancer treatments. [Damon Runyon Cancer Research Foundation Press Release]

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Cancer Research Global Summit
August 16-17, 2011
London, United Kingdom

NEW The EMBO Meeting 2011
September 10-13, 2011
Vienna, Austria

JOB OPPORTUNITIES

Chemist (STEMCELL Technologies)

Research and Development Senior Technologist (STEMCELL Technologies)

Research Associate in Synthetic Biology (Institute of Systems and Synthetic Biology)


Lab Technologist – Tissue Culture (Maternity Leave) (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Extracellular Matrix Protein Study (Università degli Studi di Genova)


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