Volume 2.22 | Jun 9

Extracellular Matrix Cell News 2.22, June 9, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
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Role of YAP/TAZ in Mechanotransduction
Scientists report the identification of the Yorkie-homologues YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif) as nuclear relays of mechanical signals exerted by extracellular matrix rigidity and cell shape. [Nature]


CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Conversion of Mechanical Force into TGF-β-Mediated Biochemical Signals
Researchers showed in a mouse model of acute tendon injury and in vitro that physical forces regulate the release of active transforming growth factor (TGF)-β from the extracellular matrix. [Curr Biol]

Small Molecule Anti-Cancer Compounds Selectively Target the Hemopexin Domain of Matrix Metalloproteinase-9
In this work, compounds that target the hemopexin domain of matrix metalloproteinase-9 were identified using an in silico docking approach and evaluated using biochemical and biological approaches. [Cancer Res]

Dentin Matrix Protein 1 (DMP1) Signals Via Cell Surface Integrin
Investigators examined DMP1’s ability to engage cell-surface receptors and subsequently activate intracellular signaling pathways. [J Biol Chem]

Angiotensin II Receptor Type 1 Blockade Decreases Connective Tissue Growth Factor-Mediated Damage and Fibrosis in Normal and Dystrophic Skeletal Muscles
Scientists proposed that AT-1 receptor blockers is a novel pharmacological tool that can be used to decrease the fibrosis induced by connective tissue growth factor in skeletal muscle associated with muscular dystrophies. [J Cell Mol Med]

Phosphorylated c-Jun and Fra-1 Induce Matrix Metalloproteinase-1 and Thereby Regulate Invasion Activity of 143B Osteosarcoma Cells
Here researchers reported an enhanced expression of matrix metalloproteinase-1 in the highly metastatic human osteosarcoma cell line 143B. [Biochim Biophys Acta]

Fluid Shear Stress Regulates the Invasive Potential of Glioma Cells Via Modulation of Migratory Activity and Matrix Metalloproteinase Expression
A 3D Modified Boyden chamber model was designed to mimic the fluid dynamic microenvironment to study the effects of fluid shear stress on the migratory activity of glioma cells. [PLoS One]

Matrix Remodeling Stimulates Stromal Autophagy, “Fueling” Cancer Cell Mitochondrial Metabolism and Metastasis
The secretion and remodeling of extracellular matrix components (such as PAI-1/2) can directly regulate both (1) autophagy in stromal fibroblasts and (2) epithelial tumor cell mitochondrial metabolism. [Cell Cycle]

The Role of Progestogens in Regulating Matrix Metalloproteinase Activity in Macrophages and Microglial Cells
Using a cellular model for vascular (macrophages) and brain (microglial) cells, researchers studied the effects of various progestogens, either alone or in combination with 17β-estradiol on the activity of matrix metalloproteinase-9. [Neurochem Res]


Halozyme and Intrexon Announce Collaboration to Develop First Subcutaneous Recombinant Alpha 1-Antitrypsin Replacement Therapy
Halozyme Therapeutics, Inc. and Intrexon Corporation announced the signing of a worldwide exclusive licensing agreement for the use of recombinant human hyaluronidase in the development of a subcutaneous injectable formulation of Intrexon Corporation’s recombinant human alpha 1-antitrypsin. [Halozyme Therapeutics, Inc. Press Release]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


NEW World Orphan Drug Congress Asia 2011
September 14-16, 2011
Seoul, Korea

NEW Screening Stem Cells 2011: From Reprogramming to Regenerative Medicine
September 26-27, 2011
Boston, United States

Visit our events page to see a complete list of events in the extracellular matrix community.


Chemist (STEMCELL Technologies)

Research and Development Senior Technologist (STEMCELL Technologies)

Postdoctoral Fellow in Systems Microscopy of Cell Migration (Karolinska Institutet)

Research Associate in Synthetic Biology (Institute of Systems and Synthetic Biology)

Proteomic Analysis of ECM of Porifera and Study of Related Enzymes (Università degli Studi di Genova)

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