Volume 2.21 | Jun 2

Extracellular Matrix Cell News 2.21, June 2, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
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TOP STORY

Creation of Bony Microenvironment with CaP and Cell-Derived ECM to Enhance Human Bone-Marrow MSC Behavior and Delivery of BMP-2
Researchers investigated whether the extracellular matrix (ECM) produced by bone marrow-derived mesenchymal stem cells (hBMSC) on a β-TCP scaffold can bind bone morphogenetic protein-2 (BMP-2) and control its release in a sustained manner, and further examined the effect of ECM and the BMP-2 released from ECM on cell behaviors. [Biomaterials]

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SCIENCE NEWS

Protein Patterning Unmasked: Laser Scanning Lithography
A research team in Texas have used laser scanning lithography to pattern multiple ligands onto glass surfaces. The pattern can be easily varied and a mask is not required. In this way, the team patterned two model extracellular matrix components simultaneously, using a GRGD-terminated alkanethiol and fibronectin. [Press release from Materials Views discussing online prepublication in Advanced Functional Materials]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Megakaryocytes Differentially Sort mRNAs for Matrix Metalloproteinases and Their Inhibitors into Platelets: A Mechanism for Regulating Synthetic Events
Because of their critical role in vascular remodelling and inflammation, researchers determined if megakaryocytes selectively dispense transcripts for matrix metalloproteinases and their tissue inhibitors into platelets. [Blood]

Guided Sprouting from Endothelial Spheroids in Fibrin Gels Aligned by Magnetic Fields and Cell-Induced Gel Compaction
The data presented here show that sprouts from human blood outgrowth endothelial cell spheroids align with fibrin fibrils, and that the extent to which the sprouts align depends upon the strength of the fibril alignment. [Biomaterials]

Regenerative Potentials of Platelet-Rich Plasma Enhanced by Collagen in Retrieving Pro-Inflammatory Cytokine-Inhibited Chondrogenesis
This study was undertaken to evaluate the role of collagen matrix to enhance platelet-rich plasma effects on pro-inflammatory cytokine-induced arthritic model. [Biomaterials]

Fabrication of Multifaceted Micropatterned Surfaces with Laser Scanning Lithography
The ability to create multifaceted, patterned surfaces with tight control over pattern size, spacing, and topography provides a platform to simultaneously investigate the complex interactions of extracellular matrix geometry, biochemistry, and topography on cell adhesion and downstream cell behavior. [Adv Funct Mater]

Bi-Stable Switch in MSF Expression is Regulated by the Concerted Signalling of TGFβ1 and the Extracellular Matrix
Since the bioactivities of both Migration Stimulating factor (MSF) and TGF-β1 are modulated by the extracellular matrix, researchers investigated whether the induction of MSF expression by TGF-β1 is also matrix dependent. [Int J Cancer]

Concentration Independent Modulation of Local Micromechanics in a Fibrin Gel
Researchers have developed a novel device for generating stiffness gradients in naturally derived extracellular matrices, where stiffness is tuned by inducing strain, while local mechanical properties are directly determined by laser tweezers based active microrheology. [PLoS ONE]

Diosgenin, a Steroidal Saponin, Inhibits Migration and Invasion of Human Prostate Cancer PC-3 Cells by Reducing Matrix Metalloproteinases Expression
The results suggested that diosgenin inhibited migration and invasion of PC-3 cells by reducing matrix metalloproteinase expression. [PLoS ONE]

Molecular Simulations Predict Novel Collagen Conformations during Cross-Link Loading
Collagen cross-linking mechanically strengthens tissues during development and aging, but there is limited data describing how force transmitted across cross-links affects molecular conformation. Researchers used Steered Molecular Dynamics to model perpendicular force through a side chain. [Matrix Biol]

Three-Dimensional Honeycomb-Patterned Chitosan/Poly(L-lactic acid) Scaffolds with Improved Mechanical and Cell Compatibility
The aim of this work was to elaborate three-dimensional scaffolds with honeycomb patterned surfaces and large open pores, and to study the influence of surface patterning on cell behavior. [J Biomed Mater Res A]

Fibrillar Films Obtained from Sodium Soap Fibers and Polyelectrolyte Multilayers
An objective of tissue engineering is to create synthetic polymer scaffolds with a fibrillar microstructure similar to the extracellular matrix. Here, researchers present a novel method for creating polymer fibers using the layer-by-layer method and sacrificial templates composed of sodium soap fibers. [J Biomed Mater Res A]

INDUSTRY NEWS

Halozyme Therapeutics to Present at the Jefferies 2011 Global Healthcare Conference on June 9
Halozyme Therapeutics, Inc., a biopharmaceutical company developing and commercializing products targeting the extracellular matrix, announced that management will be presenting at the Jefferies 2011 Global Healthcare Conference in New York. [Halozyme Therapeutics, Inc. Press Release]

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW The Cell Therapy Commercialization Summit
September 19-21, 2011
Boston, United States

Visit
our events page to see a complete list of events in the extracellular matrix community.
JOB OPPORTUNITIES

Quality Assurance Manager – Program in Children’s Regenerative Medicine (The University of Texas Medical School at Houston)

Postdoctoral Fellow in Systems Microscopy of Cell Migration (Karolinska Institutet)

Research Associate in Synthetic Biology (Institute of Systems and Synthetic Biology)


Proteomic Analysis of ECM of Porifera and Study of Related Enzymes (Università degli Studi di Genova)

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