Volume 2.14 | Apr 14

Extracellular Matrix Cell News 2.14, April 14, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
A Denatured Collagen Microfiber Scaffold Seeded with Human Fibroblasts and Keratinocytes for Skin Grafting
In vivo testing of human skin equivalents on immunocompetent and immunodeficient excisionally wounded model mice demonstrated scaffold wound biocompatibility and ability to deliver human cells after scaffold biodegradation. [Biomaterials]


Tissue Engineers Use New System to Measure Biomaterials, Structures
Researchers have developed a simple and reliable system for measuring the power that cells employ to assemble into three-dimensional tissue. [Press release from Brown University discussing online prepublication in the Proceedings of the National Academy of Sciences USA]

Pervasis Therapeutics Announces Positive Preclinical Study Data of Novel Cell Therapy for Treatment of Solid Tumors
Pervasis Therapeutics, Inc. announced preclinical data showing positive effects of PVS-30200, the company’s investigational cell therapy for the treatment of solid tumors, on controlling tumor growth and inhibiting metastases in an animal model of prostate cancer. [Press release from Pervasis Therapeutics, Inc. discussing research presented at the American Association for Cancer Research 102nd Annual Meeting 2011]


CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Quantification of the Forces Driving Self-Assembly of Three-Dimensional Microtissues
Whereas the driving force for self-assembly has often been viewed as the binding of surface proteins, these data show that cellular contraction is important for cell-cell adhesion. [Proc Natl Acad Sci U S A]

Enhanced Proliferation of Neural Stem Cells in a Collagen Hydrogel Incorporating Engineered Epidermal Growth Factor
Collagen-based hydrogels were designed to provide microenvironments for embedded cells to survive and proliferate. [Biomaterials]

Type IV Collagen-Initiated Signals Provide Survival and Growth Cues Required for Liver Metastasis
Because type IV collagen was the most prominently altered extracellular matrix protein in this model, researchers further analyzed its functional relevance to liver metastasis. [Oncogene]

Actomyosin-Generated Tension Controls the Molecular Kinetics of Focal Adhesions
Researchers present direct evidence that actomyosin contractility regulates the molecular kinetics of focal adhesions. [J Cell Sci]

Hyaluronic Acid-Based Clinical Biomaterials Derived for Cell and Molecule Delivery in Regenerative Medicine
For cell therapy and the development of clinical combination products, researchers created a hyaluronan-based synthetic extracellular matrix that provides highly reproducible, manufacturable, approvable, and affordable biomaterials. [J Control Release]

Extracellular Matrix Protein Lumican Regulates Inflammation in a Mouse Model of Colitis
Researchers investigated the role of lumican in the development of colitis mediated by intrarectal administration of the hapten 2-4-5, trinitrobenzene sulfonic acid in Lum+/+ and Lum−/− mice. [Inflamm Bowel Dis]

Effect of Surface Modification on Protein Retention and Cell Proliferation Under Strain
Researchers investigate differences in laminin surfaces that were deposited on oxidized polydimethylsiloxane with plasma treatment (plasma only) versus plasma and aminopropyltrimethoxysilane (silane-linked). [Acta Biomater]

Different Collagen Types Define Two Types of Idiopathic Epiretinal Membranes
Researchers aimed to identify differences in extracellular matrix contents between idiopathic epiretinal membranes of cellophane macular reflex or preretinal macular fibrosis type. [Histopathology]

The Influence of Patterned Nanofiber Meshes on Human Mesenchymal Stem Cell Osteogenesis
A specially designed electroconductive collector enables the electrospinning of P-NFM composed of areas of parallel/uniaxially aligned fibers and areas of random/orthogonal nanofiber distribution. [Macromol Biosci]

Snail Negatively Regulates Cell Adhesion to Extracellular Matrix and Integrin Expression via the MAPK Pathway in Prostate Cancer Cells
Researchers hypothesized that Snail will lead to decreased cellular adhesion to fibronectin and collagen I matrix through integrin regulation, concomitant with increased cell migration. [Cell Adh Migr]


MRC-CRM and iCeMS Sign Agreement on Academic Collaboration
The University of Edinburgh’s Medical Research Council Centre for Regenerative Medicine (MRC-CRM) and Kyoto University Institute for Integrated Cell-Material Sciences (iCeMS) signed a memorandum of understanding covering future collaborative research. [MRC Centre for Regenerative Medicine Press Release]

Zacharon Pharmaceuticals Announces Research and Development Collaboration with Pfizer to Develop Drugs for Multiple Rare Disorders
Zacharon Pharmaceuticals, Inc. announced that the company has entered into a strategic research collaboration with Pfizer Inc. to develop drugs for orphan diseases, including lysosomal storage disorders. [Zacharon Pharmaceuticals, Inc. Press Release]

Pieris and Daiichi Sankyo Sign Therapeutic Collaboration to Develop Anticalin® Therapeutics
Pieris AG announced the signature of a collaboration and license agreement with Daiichi Sankyo Company Limited under which Pieris will apply its proprietary Anticalin scaffold technology to discover novel Anticalins against two Daiichi Sankyo targets. [Pieris AG Press Release]

American Cancer Society Awards New Research and Training Grants
The American Cancer Society has awarded 132 national research and training grants totaling $51,473,000 to 85 institutions nationwide in the second of two grants cycles for 2011. [American Cancer Society Press Release]

Medline Premier Contract For Surgical Mesh Biomaterials Expanded to Include REVIVE® and ASSURE® Soft Tissue Repair Mesh
Medline Industries, Inc. announced that REVIVE® and ASSURE® soft tissue repair mesh has been added to their national agreement with Premier Purchasing Partners for surgical mesh biomaterials. [Medline Industries, Inc. Press Release]


National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


NEW CIRM/Regenerative Medicine Consortium – Imaging Technology for Cellular Therapies
May 26, 2011

NEW National Cancer Institute – Cancer Research Imaging Camp
June 19-24, 2011
St. Louis, United States

NEW Symposium on Advanced Wound Care (SAWC) Fall 2011
October 13-15, 2011
Las Vegas, United States

NEW American Association for Cancer Research: Metabolism and Cancer
October 16-19, 2011
Baltimore, United States

NEW 10th Annual American Association for Cancer Research Conference on Frontiers in Cancer Prevention Research
October 22-25, 2011
Boston, United States

NEW Days of Molecular Medicine 2011 – Re-Engineering Regenerative Medicine
November 10-12, 2011
Hong Kong

NEW AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics: Discovery, Biology, and Clinical Applications
November 12-16, 2011
San Francisco, United States

Visit our events page to see a complete list of events in the extracellular matrix community.


Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Quality Assurance Manager – Program in Children’s Regenerative Medicine (The University of Texas Medical School at Houston)

Postdoctoral Position – Vascular Smooth Muscle Biology (Boston University Medical School)

Assistant Professor (University of Pittsburgh School of Medicine, Center for Cellular and Molecular Engineering)

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