Volume 1.31 | Dec 9

Extracellular Matrix News 1.31, December 9, 2010.  
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Endothelial Cell Scaffolds Generated by 3D Direct Writing of Biodegradable Polymer Microfibers  ShareThis
Researchers propose a new “direct-write” process for fabricating scaffolds composed of suspended polymer microfibers that are precisely oriented in 3D, providing directional architecture for selectively guiding cell growth along a desired pathway. [Biomaterials]

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SCIENCE NEWS

Bioactive Peptides Found to Promote Wound Healing
Newly-created bioactive peptides, produced from collagenase treatment of extracellular matrix, promote wound healing through the growth of new blood vessels and epithelial tissue. [Press release from The Tufts Center for Innovations in Wound Healing Research discussing online prepublication in Wound Repair and Regeneration]

PluripotentWallchart_645x110

CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Beta-Catenin Mediates Mechanically Regulated, Transforming Growth Factor-Beta1-Induced Myofibroblast Differentiation of Aortic Valve Interstitial Cells
Myofibroblast differentiation of valve interstitial cells involves matrix stiffness-dependent crosstalk between TGF-1 and Wnt signaling pathways and may explain in part why the stiffer fibrosa is more susceptible to disease. [Arterioscler Thromb Vasc Biol]
 
Mechanics of Cell Spreading Within 3D-Micropatterned Environments
Findings highlight the dynamic relationship between cellular forces and acto-myosin contractility in 3D environments, the influence of cytoskeletal network mechanics on cell shape, as well as the importance of cell-extracellular matrix contact area in the generation of traction forces. [Lab Chip]

Structural Diversity in Integrin/Talin Interactions
Researchers employed NMR to probe interactions and dynamics, revealing marked structural diversity in the contacts between beta1A, beta1D, and beta3 tails and the Talin1 and Talin2 isoforms. [Structure]

The Disintegrin-Like and Cysteine-Rich Domains of ADAM-9 Mediate Interactions Between Melanoma Cells and Fibroblasts
Results suggest that ADAM-9 expression plays an important role in mediating cell-cell contacts between fibroblasts and melanoma cells and that these interactions contribute to proteolytic activities required during invasion of melanoma cells. [J Biol Chem]

Networked-Based Characterization of Extracellular Matrix Proteins from Adult Mouse Pulmonary and Aortic Valves
This study reports the healthy adult pulmonary and aortic valve proteomes characterized by LC/MS/MS, resulting in 2710 proteins expressed by 1513 genes, including over 300 abundant extracellular matrix proteins. [J Proteome Res]

Biomimetic Hydrogels with Vascular Endothelial Growth Factor Induce Angiogenic Processes in Both hUVEC and hMEC
The goal of the current study was to develop a system with a backbone of polyethylene glycol and grafted angiogenic signals to compare the initial angiogenic response of human umbilical vein endothelial cells (hUVEC) or human microvascular endothelial cells (hMEC). [Biomacromolecules]

Functional Composite Nanofibers of Poly(Lactide-Co-Caprolactone) Containing Gelatin-Apatite Bone Mimetic Precipitate for Bone Regeneration
Based on these results, the gelatin-apatite-poly(lactic-co-caprolactone) composite nanofiber developed in this study is considered to be potentially useful as a bone tissue regeneration matrix. [Acta Biomater]

Biological Hydrogel Synthesized from Hyaluronic Acid, Gelatin and Chondroitin Sulfate by Click Chemistry
In order to mimic the natural cartilage extracellular matrix, which is composed of coreproteins and glycosaminoglycan, a biological hydrogel was synthesized from biopolymers of hyaluronic acid, chondroitin sulfate and gelatin via click chemistry. [Acta Biomater]

Beta-Radiation Reduces the Reactivity of Extracellular Matrix Proteins in Intravascular Brachytherapy (IVBT), Resulting in Decreased Platelet Adhesion
20-Gy beta radiation significantly decreased platelet adhesion to extra cellular matrix protein vWF and collagen Type III and had no effect on the adhesion upon fibrinogen and fibronectin. [Int J Cardiol]

Extracellular Matrix of Collagen Modulates Intracellular Calcium Handling and Electrophysiological Characteristics of HL-1 Cardiomyocytes with Activation of Angiotensin II Type 1 Receptor
The study demonstrates that collagen can directly modulate the calcium dynamics and electrical activities of atrial cardiomyocytes, which are associated with the renin-angiotensin system. [J Card Fail]

Bioactive Peptides Derived from Vascular Endothelial Cell Extracellular Matrices Promote Microvascular Morphogenesis and Wound Healing In Vitro
Researchers postulated that matrix degradation by Clostridial collagenase creates bioactive fragments that can stimulate cellular responses to injury and angiogenesis. [Wound Repair Regen]

INDUSTRY NEWS

Halozyme Announces Roche Completes Patient Enrollment in Phase III Clinical Trial with Subcutaneous Herceptin®
Halozyme Therapeutics, Inc. announced that Roche has completed patient enrollment for the pivotal Phase III study of Herceptin SC (trastuzumab subcutaneous), a subcutaneous formulation that uses Halozyme’s Enhanze™ technology (rHuPH20, recombinant human hyaluronidase). [Halozyme Therapeutics, Inc. Press Release]

Audax Medical Gains Rights to Brown Regenerative Nanotech
Medical device startup Audax Medical Inc. has gained exclusive rights from Brown University for Arxis, a biomaterial intended to help regenerate diseased bone and cartilage, the company reported. [Mass High Tech]

WFUBMC Orthopaedic Researchers Awarded DOD Grant
Orthopaedic researchers at Wake Forest University Baptist Medical Center (WFUBMC) have been awarded a $2.24 million four-year grant from the U.S. Department of Defense (DOD) to study the use of keratin gel in the regeneration of damaged peripheral nerves, those in the hands, arms and feet. [Wake Forest University Baptist Medical Center Press Release]

Histogen Announces Completion of Series A Financing
Histogen, Inc. announced the successful completion of its Series A financing at $10 million. [Histogen, Inc. Press Release]

Nanoink Launches New Application for Single Cell Arrays at ASCB Annual Meeting
NanoInk’s NanoFabrication Systems Division is pleased to announce the launch of  a new application for single cell studies that enables micropatterning of proteins and polyethylene glycol-based hydrogel at sub cellular scales. [NanoInk, Inc. Press Release]

Orthovita Receives FDA Clearance for Vitoss™ Bioactive Foam-2X Bone Graft Substitute
Orthovita, Inc. announced that it received 510(k) clearance from the U.S. Food and Drug Administration (FDA) to market Vitoss Bioactive Foam-2X Bone Graft Substitute for use as a non-structural bone void filler for use in the spine, pelvis and extremities. [Orthovita, Inc. Press Release]

Halozyme Therapeutics Realigns Management
Halozyme Therapeutics, Inc. announced the appointment of Gregory I. Frost, Ph.D., to serve as president and CEO, effective immediately. [Halozyme Therapeutics, Inc. Press Release]

BioStorage Technologies Expands Global Cold Chain Logistics and Transport Offering to Include Sample Relocation Services
BioStorage Technologies, a global leader in scientific asset management, cold chain logistics and biomaterial storage for the bioscience industry, has expanded its service offerings to include a suite of global sample relocation services [BioStorage Technologies, Inc. Press Release]

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


EVENTS (Listed by Date)

4th International Conference on the Mechanics of Biomaterials and Tissues
December 11-14, 2010
Waikoloa, Hawaii

The American Society for Cell Biology 50th Annual Meeting
December 11-15, 2010
Philadelphia, United States

Pharmacology in Stem Cells Research and Regenerative Medicine
December 17, 2010
London, United Kingdom

The 3rd Guangzhou International Conference on Stem Cell Biology and Regenerative Medicine
December 17-19, 2010
Guangzhou, China

Keystone Symposia: Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

Extracellular Matrix and Cardiovascular Remodeling
January 23-28, 2011
Tahoe City, United States

5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

BIO Asia International Partnering Conference
January 24-25, 2011
Tokyo, Japan

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, D.C., United States

IQPC’s 4th Biobanking Conference
January 24-26, 2011
Philadelphia, United States

AACR-ACS Joint Meeting on Chemistry in Cancer Research: The Biological Chemistry of Inflammation as a Cause of Cancer
January 30-February 2, 2011
San Diego, United States

Molecular Medicine Tri-Conference: Stem Cells – Revolutionizing Regenerative Medicine and Personalized Therapy 2011
February 23-25, 2011
San Francisco, United States

Cell Culture World Congress 2011 – Optimising Cell Culture Development for Biopharmaceutical, Bioprocessing and Manufacture
February 28-March 2, 2011
Munich, Germany

PITTCON Conference & Expo 2011
March 13-18, 2011
Atlanta, United States

15th Annual Hilton Head Workshop – Regenerative Medicine, Innovations for Clinical Applications
March 16-19, 2011
Hilton Head Island, United States

United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom

World Stem Cells & Regenerative Medicine Congress 2011
May 9-11, 2011
London, United Kingdom

13th Annual C21 BioVentures
May 24-26, 2011
Napa, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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