Volume 1.30 | Dec 2

Extracellular Matrix News 1.30, December 2, 2010.  
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Restoration of Senescent Human Diploid Fibroblasts by Modulation of the Extracellular Matrix  ShareThis
Researchers report that interaction with extracellular matrix from young cells is sufficient to restore aged, senescent cells to an apparently youthful state. [ Aging Cell]

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SPECIAL FEATURE

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Transplantation of Human Fetal Blood Stem Cells in the Osteogenesis Imperfecta Mouse Leads to Improvement in Multi-Scale Tissue Properties
Expression of normal collagen from mature osteoblast of donor origin significantly decreased bone brittleness by improving the mechanical integrity of the bone at the molecular, tissue, and whole bone level. [Blood]
 
Cell Infiltration and Growth in a Low Density, Uncompressed Three-Dimensional Electrospun Nanofibrous Scaffold
Researchers have developed a three-dimensional cotton ball-like electrospun scaffold that consists of an accumulation of nanofibers in a low density and uncompressed manner. [Biomaterials]

Integration of Multiple Cell-Matrix Interactions into Alginate Scaffolds for Promoting Cardiac Tissue Regeneration
Researchers explored the possible role of a combination of two matrix-attached peptides, the adhesion peptide G4RGDY and heparin-binding peptide G4SPPRRARVTY, in cardiac tissue regeneration. [Biomaterials]
 
The Effect of Elastin on Chondrocyte Adhesion and Proliferation on Poly (Epsilon-Caprolactone)/Elastin Composites
Results demonstrate the potential of using poly (epsilon-caprolactone)/elastin composites for cartilage repair. [Biomaterials]

Laminins, via Heparan Sulfate Proteoglycans, Participate in Zebrafish Myotome Morphogenesis by Modulating the Pattern of Bmp Responsiveness
Results show that laminins, via heparan sulfate proteoglycans, are instrumental in patterning Bmp responsiveness and that Bmp signaling restricts Engrailed expression to the central domain. [Development]
 
Dymeclin, the Gene Underlying Dyggve-Melchior-Clausen Syndrome, Encodes a Protein Integral to Extracellular Matrix and Golgi Organization and Is Associated with Protein Secretion Pathways Critical in Bone Development
Data identify the role of Dymeclin in secretory pathways essential to endochondral bone formation during early development. [Hum Mutat]
 
The Kinesin KIF9 and Reggie/Flotillin Proteins Regulate Matrix Degradation by Macrophage Podosomes
Researchers identify the kinesin KIF9 and reggie/flotillin proteins as novel regulators of macrophage podosomes and show that their interaction is critical for the matrix-degrading ability of these structures. [Mol Biol Cell]
 
Altered Oxidative Stress Responses and Increased Type I Collagen Expression in Bicuspid Aortic Valve Patients
Data support the hypothesis that bicuspid aortic valve smooth muscle cells lack sufficient resistance to reactive oxygen species to maintain extracellular matrix homeostasis, which imparts a predisposition to thoracic aortic aneurysms. [Ann Thorac Surg]
 
‘Young’ Oral Fibroblasts Are Geno/Phenotypically Distinct
Researchers conclude that oral mucosal fibroblasts exhibit a preferential healing response in vivo, due to their ‘replicatively younger’ phenotype when compared with that of patient-matched skin fibroblasts. [J Dent Res]

Attachment to Extracellular Matrices Is Enhanced in Human Endometriotic Stromal Cells: A Possible Mechanism Underlying the Pathogenesis of Endometriosis
Adhesive properties of endometriotic stromal cells and normal eutopic endometrial cells to various extracellular matrix proteins were investigated by in vitro cell adhesion assays. [Eur J Obstet Gynecol Reprod Biol]

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INDUSTRY NEWS

Halozyme Therapeutics to Present at Upcoming Investor Conference
Halozyme Therapeutics, Inc. announced that management will be presenting at the 5th Annual Canaccord Genuity Cardiovascular, Diabetes and Obesity Conference. [Halozyme Therapeutics, Inc. Press Release]
 
Growth Review Highlights Life Sciences as a Key Sector; Confirms Introduction of Patent Box and Reviews R&D Tax Credits
The government’s growth review “The path to strong, sustainable and balanced growth”, launched by the Chancellor of the Exchequer, George Osborne, is a promising road map to enable the UK to build its vibrant life sciences sector. [The Association of the British Pharmaceutical Industry Press Release]
 
New International Competition Focuses on Early Career Scientists
The Howard Hughes Medical Institute launched an international competition to select up to 35 early career scientists working at academic institutions in 18 countries on five continents with the goal of helping these talented individuals establish independent research programs. [Howard Hughes Medical Institute Press Release]

POLICY NEWS

FDA and Life Sciences Industry Relationship Is Complicated by New Science and Changing Expectations, Finds PwC Survey
Growing public demand for increased medical device and drug safety, as well as the need to develop medical products faster, is complicating the current regulatory approval process and relationship between the life sciences industry and its chief regulator, the U.S. Food and Drug Administration, according to a new PricewaterhouseCoopers (PwC) report. [Food and Drug Administration, United States]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


EVENTS (Listed by Date)

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America (TERMIS-NA) 2010 Annual Conference
December 5-8, 2010
Orlando, United States

NEW  4th International Conference on the Mechanics of Biomaterials and Tissues
December 11-14, 2010
Waikoloa, Hawaii

The American Society for Cell Biology 50th Annual Meeting
December 11-15, 2010
Philadelphia, United States

Pharmacology in Stem Cells Research and Regenerative Medicine
December 17, 2010
London, United Kingdom

The 3rd Guangzhou International Conference on Stem Cell Biology and Regenerative Medicine
December 17-19, 2010
Guangzhou, China

Keystone Symposia: Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

Extracellular Matrix and Cardiovascular Remodeling
January 23-28, 2011
Tahoe City, United States

5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

BIO Asia International Partnering Conference
January 24-25, 2011
Tokyo, Japan

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, D.C., United States

IQPC’s 4th Biobanking Conference
January 24-26, 2011
Philadelphia, United States

AACR-ACS Joint Meeting on Chemistry in Cancer Research: The Biological Chemistry of Inflammation as a Cause of Cancer
January 30-February 2, 2011
San Diego, United States

Molecular Medicine Tri-Conference: Stem Cells – Revolutionizing Regenerative Medicine and Personalized Therapy 2011
February 23-25, 2011
San Francisco, United States

NEW Cell Culture World Congress 2011 – Optimising Cell Culture Development for Biopharmaceutical, Bioprocessing and Manufacture
February 28-March 2, 2011
Munich, Germany

NEW PITTCON Conference & Expo 2011
March 13-18, 2011
Atlanta, United States

15th Annual Hilton Head Workshop – Regenerative Medicine, Innovations for Clinical Applications
March 16-19, 2011
Hilton Head Island, United States

United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom

NEW World Stem Cells & Regenerative Medicine Congress 2011
May 9-11, 2011
London, United Kingdom

13th Annual C21 BioVentures
May 24-26, 2011
Napa, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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