Volume 1.25 | Oct 21

Extracellular Matrix News 1.25, October 21, 2010.  
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The Isolation of Cell Derived Extracellular Matrix Constructs Using Sacrificial Open-Cell Foams  ShareThis
Researchers have developed an approach to isolate extracellular matrix in bulk from populations of living cells grown in culture on three-dimensional substrates. [ Biomaterials]



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Scientists Turn Stem Cells into Cells for Cartilage Repair
Researchers took human embryonic stem cells and developed a culture procedure involving a precise sequential program of conditions to specifically produce chondrocytes. [Press release from The University of Manchester discussing online prepublication in Nature Biotechnology]

Wake-Up Call: Researchers Find Sleepy Fibroblasts Are Surprisingly Lively
Fibroblasts long have been viewed by scientists as crucial but dull, quietly performing their essential function of providing the structural framework for tissue. But now, a team of scientists has discovered that while these unassuming cells are in “sleep” mode, they actually are working much harder than previously thought to fend off destructive chemicals. [Press release from Princeton University discussing online prepublication in PLoS Biology]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Quiescent Fibroblasts Exhibit High Metabolic Activity
Quiescent fibroblasts, relieved of the biosynthetic requirements associated with generating progeny, direct their metabolic activity to preservation of self integrity and alternative functions beneficial to the organism as a whole. [PLoS Biol]
LKB1 Inhibits Lung Cancer Progression Through Lysyl Oxidase and Extracellular Matrix Remodeling
Findings provide evidence of how LKB1 loss of function promotes lung cancer malignancy through remodeling of extracellular matrix microenvironment, and identify lysyl oxidase as a potential target for disease treatment in lung cancer patients. [Proc Natl Acad Sci U S A]
Bioengineering of Living Renal Membranes Consisting of Hierarchical, Bioactive Supramolecular Meshes and Human Tubular Cells
Researchers report on a bottom-up approach based on hydrogen-bonded supramolecular polymers and extracellular matrix-peptides to make an electro-spun, bioactive supramolecular mesh which can be applied as synthetic basement membrane. [Biomaterials]

Expression of Integrin Beta1 by Fibroblasts Is Required for Tissue Repair In Vivo
Researchers show that mice containing a fibroblast-specific deletion of integrin beta1 exhibit delayed cutaneous wound closure and less granulation tissue formation, including reduced production of new extracellular matrix and reduced expression of alpha-smooth muscle actin. [J Cell Sci]
Mast Cell Fibroblastoid Differentiation Mediated by Airway Smooth Muscle in Asthma
Data indicate that in asthma, airway smooth muscle-derived extracellular matrix proteins mediate human mast cell transition to a fibroblastoid phenotype, suggesting that this may be pivotal in the development of airway dysfunction in asthma. [J Immunol]
ErbB2 Stabilizes Epidermal Growth Factor Receptor (EGFR) Expression via Erk and Sprouty2 in Extracellular Matrix Detached Cells
Researchers show that loss of extracellular matrix (ECM) attachment causes downregulation of EGFR and beta1 integrin protein and mRNA expression and that ErbB2, which is amplified in 25% of breast tumors, reverses these effects of ECM deprivation. [J Biol Chem]
Proline Periodicity Modulates the Self-Assembly Properties of Elastin-Like Polypeptides
Data strongly support a model where proline-poor regions of the elastin monomer provide a unique contribution to assembly, and suggest a role for localized beta-sheet in mediating self-assembly interactions. [J Biol Chem]
Fibroblast Cytoskeletal Remodeling Contributes to Connective Tissue Tension
Fibroblasts within areolar connective tissue exhibit dynamic cytoskeletal remodeling within minutes in response to tissue stretch ex vivo and in vivo . Here, researchers tested the hypothesis that fibroblasts, through this cytoskeletal remodeling, actively contribute to the viscoelastic behavior of the whole tissue. [J Cell Physiol]
Exploring Cellular Contact Guidance Using Gradient Nanogratings
Researchers developed a strategy to fabricate controlled substrates with a wide range of pattern shapes and surface chemistries and to separate surface chemistry and topography effects. [Biomacromolecules]
Biomaterials from Ultrasonication-Induced Silk Fibroin-Hyaluronic Acid Hydrogels
Researchers report formation of biocompatible hydrogels using physically cross-linked biopolymers. Gelation of silk fibroin (from B. mori silkworm) aqueous solution was effected by ultrasonication and used to entrap blended, un-cross-linked, hyaluronic acid without chemical cross-linking. [Biomacromolecules]

Adrenomedullin Increases Fibroblast-Like Synoviocyte Adhesion to Extracellular Matrix Proteins by Upregulating Integrin Activation
Researchers investigated whether adrenomedullin mediated fibroblast-like synoviocyte adhesion to extracellular matrix proteins. [Arthritis Res Ther]


Sanofi-aventis Establishes Research Collaboration with Harvard University
Sanofi-aventis announced a research collaboration with Harvard University. The goal of the collaboration is to advance knowledge in the area of human health through basic and applied research and to promote scientific exchange between Harvard University and Sanofi-aventis. [Sanofi-aventis Press Release]
$3.7 Million to Push Cancer Discoveries Down the ‘Pipeline’
The Cancer Institute New South Wales has awarded the Garvan Institute’s Cancer Research Program $3.7 million, research funding that should lead to improved clinical decision-making for breast, prostate and pancreatic cancer within the next 5 years. [The Garvan Institute Press Release]
Biomerix Granted U.S. Patent for Its Proprietary Biomaterial Platform Technology
Biomerix Corporation announced that the United States Patent and Trademark Office has granted a patent for its proprietary biomaterial platform technology titled “Reticulated elastomeric matrices, their manufacture and use in implantable devices.” [Biomerix Corporation Press Release]


Cancer Chief Varmus Draws Up a List of Unsolved Mysteries
Harold Varmus has made a start on one of his first priorities as chief of the U.S. National Cancer Institute: coming up with a set of key unanswered questions. [National Cancer Institute, United States]
FDA Writes Prescription for IT Innovation
The Food and Drug Administration is prioritizing IT as part of its five-year strategic plan, including accelerating a program to build innovative devices to improve field and laboratory analysis. [Food and Drug Administration, United States]
Partnerships To Advance the National Occupational Research Agenda (NORA) (FR Doc. 2010-25973) [Centers for Disease Control and Prevention, United States]
Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26362) [National Institutes of Health, United States]
Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26363) [National Institutes of Health, United States]
Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26317) [National Institutes of Health, United States]
Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26028) [National Institutes of Health, United States]
Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26033) [National Institutes of Health, United States]
National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-26390) [National Institutes of Health, United States]
National Cancer Institute; Notice of Meeting (FR Doc. 2010-26032) [National Institutes of Health, United States]
National Cancer Institute; Notice of Closed Meetings (FR Doc. 2010-26035) [National Institutes of Health, United States]
National Institute of General Medical Sciences; Notice of Closed Meeting (FR Doc. 2010-26037) [National Institutes of Health, United States]
National Institute of General Medical Sciences; Notice of Closed Meeting (FR Doc. 2010-26075) [National Institutes of Health, United States]
Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-26036) [National Institutes of Health, United States]

EVENTS (Listed by Date)

American Society for Matrix Biology (ASMB) 2010 Biennial Meeting
October 24-27, 2010
Charleston, United States

Frontiers in Tumour Progression
October 24-27, 2010
Madrid, Spain

3rd Annual Dubai Congress on Anti-Aging and Aesthetic Medicine (DCAAAM)
October 26-27, 2010
Dubai, United Arab Emirates

2nd Annual Stem Cells Asia and Regenerative Medicine Congress
October 26-28, 2010
Seoul, Korea

Select Biosciences 2nd Annual Lab-on-a-Chip World Congress
October 28-29, 2010
San Diego, United States

Fraunhofer Life Science Symposium Leipzig 2010
October 29-30, 2010
Leipzig, Germany

6th National Cancer Research Institute (NCRI) Conference
November 7-10, 2010
Liverpool, United Kingdom

Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC)
November 12-13, 2010
Tianjin, China

Medica 2010
November 17-20, 2010
Dusseldorf, Germany

8th Annual Commercial Translation of Regenerative Medicine Conference
November 18-19, 2010
London, United Kingdom

Translational Excellence in Regenerative Medicine (TeRM) – Biophysical Stimuli and Mass Transport for Tissue Development
November 18-19, 2010
Lattrop, The Netherlands

Stem Cell Network’s 10th Annual Scientific Meeting
November 22-24, 2010
Calgary, Alberta

First Berlin-Brandenburg School for Regenerative Therapies (BSRT) PhD Symposium
December 1-3, 2010
Berlin, Germany

NEW 2nd European Association for Cardio-Thoracic Surgery (EACTS) Meeting on Cardiac and Pulmonary Regeneration
December 3-4, 2010
Vienna, Austria

Tissue Engineering & Regenerative Medicine International Society – North America (TERMIS-NA) 2010 Annual Conference
December 5-8, 2010
Orlando, United States

The American Society for Cell Biology 50th Annual Meeting
December 11-15, 2010
Philadelphia, United States

Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

Extracellular Matrix and Cardiovascular Remodeling
January 23-28, 2011
Tahoe City, United States

Select Biosciences 5th Annual Stem Cells World Congress
January 24-25, 2011
San Diego, United States

BIO Asia International Partnering Conference
January 24-25, 2011
Tokyo, Japan

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, DC, United States

AACR-ACS Joint Meeting on Chemistry in Cancer Research: The Biological Chemistry of Inflammation as a Cause of Cancer
January 30-February 2, 2011
San Diego, United Sates

Molecular Medicine Tri-Conference – Stem Cells: Revolutionizing Regenerative Medicine and Personalized Therapy 2011
February 23-25, 2011
San Francisco, United States

Visit our events page  to stay up to date with the latest events in the cell, gene and immunotherapy community.




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