Volume 1.23 | Oct 7

Extracellular Matrix News 1.23, October 7, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Surgeons Create Functional Artificial Pancreatic Tissue  ShareThis
Surgeons from Massachusetts General Hospital, Boston, are reporting on a whole new strategy for controlling insulin dependent diabetes without daily injections of insulin. They have bio-engineered a novel matrix that serves as a scaffold for seeding supportive stem cells as well as pancreatic islets. [Press release from Newswise discussing research presented at the 2010 Annual Clinical Congress of the American College of Surgeons]

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SCIENCE NEWS

Elasticity Found to Stretch Stem Cell Growth to Higher Levels
One of the major challenges in stem cell transplants is how to obtain sufficient numbers of these remarkably rare cells to put into patients. To help overcome this issue, researchers have found a way to increase the number of blood-forming stem cells when growing them outside of the body. They combined routinely-used cell hormones with a new elastic-like substance called tropoelastin to coat the plates on which the cells were grown. [Press release from the Centenary Institute discussing online prepublication in Nature Biotechnology]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Substrate Elasticity Provides Mechanical Signals for the Expansion of Hemopoietic Stem and Progenitor Cells
Data suggest that substrate elasticity and tensegrity are important mechanisms influencing hemopoietic stem and progenitor cell subsets and could be exploited to facilitate cell culture. [Nat Biotechnol]

Collective Cell Migration on Artificial Extracellular Matrix Proteins Containing Full-Length Fibronectin Domains
Protein-based biomaterials that promote rapid wound healing are prepared by expression of artificial genes in bacterial cells. Artificial extracellular matrix proteins containing full-length fibronectin domains 9 and 10 exhibit strong alpha5beta1 integrin binding and support rapid spreading, proliferation, and collective migration of fibroblasts. [ Adv Mater]

A Doxycycline Loaded, Controlled-Release, Biodegradable Fiber for the Treatment of Aortic Aneurysms
Researchers demonstrated the possibility of local administration of doxycycline controlled-release biodegradable fiber for aortic aneurysm in mice. [Biomaterials]

Multilayered Silk Scaffolds for Meniscus Tissue Engineering
Improved scaffold mechanical properties along with extracellular matrix alignment with time in culture suggest the multiporous silk construct as a useful micro-patterned template for directed tissue growth with respect to form and function of meniscus-like tissue. [Biomaterials]

Expression of the Collagen VI Alpha5 and Alpha6 Chains in Normal Human Skin and in Skin of Patients with Collagen VI-Related Myopathies
To gain insight into the function of the newly identified collagen VI alpha5 and alpha6 chains in human skin, researchers studied their expression and localization in normal subjects and in genetically characterized Ullrich congenital muscular dystrophy and Bethlem myopathy patients. [J Invest Dermatol]

Discoidin Domain Receptor 1 Regulates Bronchial Epithelial Repair and Matrix Metalloproteinase Production
Data suggest that extracellular matrix signaling via discoidin domain receptor 1 regulates aspects of bronchial epithelial repair, integrity and matrix metalloproteinase expression in the airways. [Eur Respir J]

Gelation Behavior by the Lanthanoid Adsorption of the Cyanobacterial Extracellular Polysaccharide
The extracellular matrix of Aphanothece sacrum, sacran, may adsorb metal ions to create fibrous nanostructures that reinforce the jelly matrix. [Biomacromolecules]

Site-Specific PEGylation of Bone Morphogenetic Protein-2 Cysteine Analogues
The results indicate that specific attachment of poly(ethylene glycol) (PEG) at engineered sites of bone morphogenetic protein-2 is possible and that the attachment site is critical for biological activity. [Bioconjug Chem]

Increased Matrix Metalloproteinase Activation in Esophageal Squamous Cell Carcinoma
Increased levels of matrix metalloproteinases occur in esophageal squamous cell carcinomas suggesting their up-regulation is important in esophageal tumorigenesis. [J Transl Med]

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INDUSTRY NEWS

Einstein Receives $30 Million to Study Protein Form and Function
The National Institute of General Medical Sciences has awarded Albert Einstein College of Medicine of Yeshiva University a five-year, $30 million grant to study the structure and function of thousands of biomedically important proteins. [Albert Einstein College of Medicine of Yeshiva University Press Release]

Cardium Gains Exclusive Access to Novel Polymer-Based Nitric Oxide Technology for Expansion of Wound Healing Product Portfolio
Cardium Therapeutics announced that it has gained exclusive access to commercial development rights for certain novel supramacromolecular polymer complexes enabling regulatable and localized topical delivery of nitric oxide for prolonged periods of one to three weeks, to broaden and expand the Company’s wound healing and tissue regeneration portfolio. [Cardium Therapeutics Press Release]

Kollodis BioSciences Announces MAPTrix™ ECM Product Line Extension to Strengthen Product Offering
Kollodis BioSciences announced the expansion of its ECM product line to address the needs of the emerging stem cell culture market. [Newswire Today]

Baxter Presents Data from Interim Analyses of Phase III Clinical Trial of HyQ at European Society for Immunodeficiencies Meeting
Data from interim analyses of a Phase III clinical study in patients with primary immune deficiency who received Baxter’s HyQ were presented at the 26th meeting of the European Society for Immunodeficiencies in Istanbul, Turkey. HyQ is an immune globulin therapy facilitated subcutaneously by recombinant human hyaluronidase, a dispersion and permeation enhancer. [Halozyme Therapeutics Press Release]

Shrinking U.S. Biotechnology Sector Lost 25% of Companies in Past 3 Years
One hundred publicly traded biotechnology companies in the U.S. have been acquired or ceased operations since the end of 2007, a 25 percent drop in the number of active companies, a report said. [Bloomberg]

POLICY NEWS

Lawmakers Introduce Bipartisan Legislation to Create Jobs and Promote Investment in Life Sciences
U.S. Representatives introduced bipartisan legislation that will provide tax incentives for small and mid-sized businesses to invest in life sciences research and development on a targeted basis. The Life Sciences Jobs and Investment Act of 2010 provides an opportunity to enhance medical innovation, life sciences education and job creation in the United States. [House of Representatives, United States]

NIH and FDA Announce Awards to Advance Regulatory Science
The National Institutes of Health will award $9.4 million over three years to support four research projects in regulatory science. This research is conducted in partnership with the U.S. Food and Drug Administration, which will contribute approximately $950,000. [National Institutes of Health and Food and Drug Administration, United States]

NIH Announces New Program to Accelerate Research Independence
The National Institutes of Health intends to invest approximately $60 million over the next five years in the NIH Director’s Early Independence Award program to help junior investigators leapfrog over traditional post-doctoral training and move into independent academic positions at U.S. institutions, directly upon completion of their graduate research degrees. [National Institutes of Health, United States]

NIH Grants Will Advance Studies of the Form and Function of Proteins
The National Institutes of Health has awarded 23 grants for structural biology research totaling up to $290 million over five years. The projects will focus on determining the shapes and functions of proteins important in biology and medicine. [National Institutes of Health, United States]

NCBI launches the Database of Genomic Structural Variations
The National Institutes of Health announces the launch of a new resource, called the Database of Genomic Structural Variation, or dbVar, to help scientists understand how differences in DNA contribute to human health and disease. [National Institutes of Health, United States]
 
NIH Transformative Research Project Awards Hasten Innovation
The National Institutes of Health will award up to $64 million over five years to encourage exploration of exceptionally innovative and original research ideas that have the potential for extraordinary impact. [National Institutes of Health, United States]
 
FDA to Push for More Investment in Science
Health regulators plan to spend millions of dollars to step up their scientific prowess in a move that officials say will help quickly get new treatments to patients and protect the public against possible health threats. [Food and Drug Administration, United States]

FDA Issues Final Rule on Safety Information During Clinical Trials
The U.S. Food and Drug Administration (FDA) issued a final rule that clarifies what safety information must be reported during clinical trials of investigational drugs and biologics. [Food and Drug Administration, United States]

Spain’s Science Budget Proposal: Not as Bad as Feared, But Not Good
After weeks during which Spanish researchers fretted nervously about possibly significant cuts to their country’s science budget, Spanish Science and Innovation Minister Cristina Garmendia tried in a press conference to give a reassuring message to the scientific community: the ministry will have about the same amount of money next year as proposed in 2010 with which to fund competitive research projects and scholarships, support national research institutes, and give loans to R&D companies. [Ministry of Science, Spain]

Tumor Microenvironment Network (TMEN) (U54) (RFA-CA-10-021) [Department of Health and Human Services, United States]

Center for Scientific Review; Amended Notice of Meeting (FR Doc. 2010-25171) [National Institutes of Health, United States]
 
Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-25180) [National Institutes of Health, United States]
 
Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-25185) [National Institutes of Health, United States]

National Center for Research Resources; Notice of Closed Meeting (FR Doc. 2010-25176) [National Institutes of Health, United States]
 
National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting (FR Doc. 2010-25172) [National Institutes of Health, United States]

Investigational New Drug Safety Reporting Requirements for Human Drug and Biological Products and Safety Reporting Requirements for Bioavailability and Bioequivalence Studies in Humans [Docket No. FDA-2000-N-0108] (Formerly Docket No. 00N-1484) [Food and Drug Administration, United States]

EVENTS (Listed by Date)

35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy

3rd Biobridge “Generation Regeneration” Conference
October 11, 2010
Geneva, Switzerland

BioStar 2010 – 4th Congress on Regenerative Biology and Medicine
October 13-15, 2010
Stuttgart, Germany

The American Society for Bone and Mineral Research (ASBMR) 2010 Annual Meeting
October 15-19, 2010
Toronto, Canada

Stem Cells and Regenerative Medicine – New Solutions to Old Problems
October 18-20, 2010
San Antonio, United States

American Society for Matrix Biology (ASMB) 2010 Biennial Meeting
October 24-27, 2010
Charleston, United States

Frontiers in Tumour Progression
October 24-27, 2010
Madrid, Spain

3rd Annual Dubai Congress on Anti-Aging and Aesthetic Medicine (DCAAAM)
October 26-27, 2010
Dubai, United Arab Emirates

2nd Annual Stem Cells Asia and Regenerative Medicine Congress
October 26-28, 2010
Seoul, Korea

Select Biosciences 2nd Annual Lab-on-a-Chip World Congress
October 28-29, 2010
San Diego, United States

Fraunhofer Life Science Symposium Leipzig 2010
October 29-30, 2010
Leipzig, Germany

6th National Cancer Research Institute (NCRI) Conference
November 7-10, 2010
Liverpool, United Kingdom

Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC)
November 12-13, 2010
Tianjin, China

Medica 2010
November 17-20, 2010
Dusseldorf, Germany

8th Annual Commercial Translation of Regenerative Medicine Conference
November 18-19, 2010
London, United Kingdom

Translational Excellence in Regenerative Medicine (TeRM) – Biophysical Stimuli and Mass Transport for Tissue Development
November 18-19, 2010
Lattrop, The Netherlands

Stem Cell Network’s 10th Annual Scientific Meeting
November 22-24, 2010
Calgary, Alberta

First Berlin-Brandenburg School for Regenerative Therapies (BSRT) PhD Symposium
December 1-3, 2010
Berlin, Germany

Tissue Engineering & Regenerative Medicine International Society – North America (TERMIS-NA) 2010 Annual Conference
December 5-8, 2010
Orlando, United States

The American Society for Cell Biology 50th Annual Meeting
December 11-15, 2010
Philadelphia, United States

Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

Extracellular Matrix and Cardiovascular Remodeling
January 23-28, 2011
Tahoe City, United States

Select Biosciences 5th Annual Stem Cells World Congress
January 24-25, 2011
San Diego, United States

BIO Asia International Partnering Conference
January 24-25, 2011
Tokyo, Japan

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, DC, United States

Molecular Medicine Tri-Conference – Stem Cells: Revolutionizing Regenerative Medicine and Personalized Therapy 2011
February 23-25, 2011
San Francisco, United States

Visit our events page  to stay up to date with the latest events in the cell, gene and immunotherapy community.

 

 


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