Volume 1.22 | Sep 30

Extracellular Matrix News 1.22, September 30, 2010
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Recombinant Spider Silk as Matrices for Cell Culture  ShareThis
The recombinant miniature spider silk protein, 4RepCT, was used to fabricate film, foam, fiber and mesh matrices of different dimensionality, microstructure and nanotopography. These matrices were evaluated regarding their suitability for cell culturing. [Biomaterials]



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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Membrane-Type Matrix Metalloproteinases (MT-MMPs) Are Indispensable for Placental Labyrinth Formation and Development
Data identify essential but interchangeable roles for MT1-MMP or MT2-MMP in placental vasculogenesis and provide the first example of selective temporal and spatial MMP activity required for development of the mouse embryo. [Blood]

Homologous Structure-Function Relationships Between Native Fibrocartilage and Tissue Engineered from MSC-Seeded Nanofibrous Scaffolds
Findings strongly support the use of electrospun scaffolds and mesenchymal stem cells (MSCs) for fibrocartilage tissue engineering, and provide insight on the structure-function relations of both engineered and native biomaterials. [Biomaterials]

The Effect of Source Animal Age Upon Extracellular Matrix Scaffold Properties
The objective of the present study was to compare the structural, mechanical, and compositional properties of small intestinal submucosa-extracellular matrix harvested from pigs that differed only in age. [Biomaterials]

Organ-Derived Coatings on Electrospun Nanofibers as Ex Vivo Microenvironments
Cells plated on extracts isolated from fibrotic murine lungs secreted larger amounts of extracellular matrix, adopted a fibroblastic morphology, and exhibited increased myofibroblast gene expression after 8 and 14 days; cells plated on extracts from non-fibrotic lungs did not. [Biomaterials]

Biological Synthesis of Tooth Enamel Instructed by an Artificial Matrix
Using a self-assembling bioactive matrix, researchers demonstrate the ability to induce ectopic formation of enamel at chosen sites adjacent to a mouse incisor cultured in vivo under the kidney capsule. [Biomaterials]

The Role of Transglutaminase 2 and Osteopontin in Matrix Protein Supplemented Microencapsulation of Marrow Stromal Cells
Microcapsules supplemented with fibronectin/fibrinogen (FN/FG), polymeric osteopontin and transglutaminase 2 demonstrated significantly less apoptotic cells than FN/FG microcapsules. [Biomaterials]

The Discrimination of Type I and Type II Collagen and the Label-Free Imaging of Engineered Cartilage Tissue
Researchers determined the second order susceptibility tensor ratios of type I and II collagens at each pixel, and displayed the results as images. [Biomaterials]

Phospholipid Scramblase 1 Is Secreted by an Unconventional Mechanism and Interacts with the Extracellular Matrix Protein 1 in the Dermal Epidermal Junction Zone of Human Skin
Researchers demonstrate that phospholipid scramblase 1(PLSCR1) interacts with the tandem repeat region of extracellular matrix protein 1a in the dermal epidermal junction zone of the human skin and provide for the first time experimental evidence that PLSCR1 is secreted by an unconventional secretion pathway. [J Biol Chem]

A Comparison of the Sensitivity, Specificity, and Molecular Weight Accuracy of Three Different Commercially Available Hyaluronan ELISA-Like Assays
Three commonly-used, commercially available hyaluronan (HA) ELISA-like assays (from Corgenix, Echelon and R&D) were compared on the basis of accuracy, sample variability and ability to measure a range of HA sizes. [Glycobiology]



Biomerix Corporation and Synthecon Announce Strategic Distribution Agreement
Biomerix Corporation and Synthecon announced a strategic distribution agreement for three-dimensional cell culture scaffolds developed using Biomerix Corporation’s unique biomaterial technology. [Biomerix Corporation Press Release]

U.S. Budgets $1.9 Billion to Back New Drugs and Vaccines
The U.S. has $1.9 billion available for new biotech initiatives that can fight off the biologic threats of the future. And the government’s Biomedical Advanced Research and Development Authority has handed out contracts worth potentially more than $100 million to help accelerate work on a range of drug and vaccine development technologies. [FierceBiotech Research]

Scientists Seek Donations on Innovative Micro-Philanthropy Site
A creative new Web site connects funding proposals by scientists with contributors who want to support the work out of the goodness of their hearts. [ScienceInsider]

Clinical Update on TAMARIS Phase III Trial for NV1FGF
Sanofi-aventis announced that the Phase III TAMARIS trial evaluating the investigational angiogenic therapy NV1FGF (riferminogen pecaplasmid) did not meet its primary endpoint. [Sanofi-aventis Press Release]

Stem Cells That Save Big Pharma a Bundle
Researchers hope they can use human tissue created from stem cells to help identify potentially dangerous side-effects from drugs under development before human trials. [BusinessWeek]


New Legislation Introduced to Form First U.S. National Strategy for Regenerative Medicine, with Commendation from the Alliance for Regenerative Medicine
The Alliance for Regenerative Medicine announced the introduction of the bi-partisan Regenerative Medicine Promotion Act of 2010 in the U.S. House of Representatives. [House of Representatives , United States]

Lawmakers Introduce Bipartisan Legislation to Create Jobs and Promote Investment in Life Sciences
U.S. Representatives introduced bipartisan legislation that will provide tax incentives for small and mid-sized businesses to invest in life sciences research and development on a targeted basis. The Life Sciences Jobs and Investment Act of 2010 provides an opportunity to enhance medical innovation, life sciences education and job creation in the United States. [House of Representatives, United States]

NIH and FDA Announce Awards to Advance Regulatory Science
The National Institutes of Health will award $9.4 million over three years to support four research projects in regulatory science. This research is conducted in partnership with the U.S. Food and Drug Administration, which will contribute approximately $950,000. [National Institutes of Health and Food and Drug Administration, United States]

U.K. Research Leaders Make Final Stand Against Science Cuts
Top officials from six U.K. universities joined Martin Rees, president of the Royal Society, in London in a last-ditch attempt to avert the government’s expected cuts in science funding, which will be detailed in its forthcoming comprehensive spending review, scheduled for release on 20 October. [Royal Society, United Kingdom]

European Medicines Agency Publishes First Review of Orphan Designation
The European Medicines Agency has published the first of its ‘review of orphan designation’ documents. [European Medicines Agency, European Union]

European Medicines Agency Welcomes Adoption of New Pharmacovigilance Legislation by European Parliament
The European Medicines Agency welcomes the adoption of the new pharmacovigilance legislation by the European Parliament. This is a major step towards the legislation coming into force, currently expected for mid-2012. [European Medicines Agency, European Union]

Guidance on Withdrawal of Subjects From Research: Data Retention and Other Related Issues (FR Doc. 2010-23517) [Department of Health and Human Services, United States]

Office of Biotechnology Activities, Office of Science Policy, Office of the Director; Notice of Meeting (FR Doc. 2010-23947) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-23952) [National Institutes of Health, United States]

EVENTS (Listed by Date)

4th International Conference on Biofabrication
October 4-6, 2010
Philadelphia, United States

NEW 5th World Congress on Preventive & Regenerative Medicine (WCRM) 2010
October 5-7, 2010
Hannover, Germany

NEW Bio-IT World Europe Conference & Expo
October 5-7, 2010
Hannover, Germany

bone-tec 2010 – International Bone-Tissue-Engineering Congress
October 7-10, 2010
Hannover, Germany

35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy

NEW 3rd Biobridge “Generation Regeneration” Conference
October 11, 2010
Geneva, Switzerland

BioStar 2010 – 4th Congress on Regenerative Biology and Medicine
October 13-15, 2010
Stuttgart, Germany

NEW The American Society for Bone and Mineral Research (ASBMR) 2010 Annual Meeting
October 15-19, 2010
Toronto, Canada

NEW Stem Cells and Regenerative Medicine – New Solutions to Old Problems
October 18-20, 2010
San Antonio, United States

American Society for Matrix Biology (ASMB) 2010 Biennial Meeting
October 24-27, 2010
Charleston, United States

NEW Frontiers in Tumour Progression
October 24-27, 2010
Madrid, Spain

NEW 3rd Annual Dubai Congress on Anti-Aging and Aesthetic Medicine (DCAAAM)
October 26-27, 2010
Dubai, United Arab Emirates

NEW 2nd Annual Stem Cells Asia and Regenerative Medicine Congress
October 26-28, 2010
Seoul, Korea

Select Biosciences 2nd Annual Lab-on-a-Chip World Congress
October 28-29, 2010
San Diego, United States

Fraunhofer Life Science Symposium Leipzig 2010
October 29-30, 2010
Leipzig, Germany

6th National Cancer Research Institute (NCRI) Conference
November 7-10, 2010
Liverpool, United Kingdom

Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC)
November 12-13, 2010
Tianjin, China

Medica 2010
November 17-20, 2010
Dusseldorf, Germany

NEW 8th Annual Commercial Translation of Regenerative Medicine Conference
November 18-19, 2010
London, United Kingdom

Translational Excellence in Regenerative Medicine (TeRM) – Biophysical Stimuli and Mass Transport for Tissue Development
November 18-19, 2010
Lattrop, The Netherlands

NEW Stem Cell Network’s 10th Annual Scientific Meeting
November 22-24, 2010
Calgary, Alberta

First Berlin-Brandenburg School for Regenerative Therapies (BSRT) PhD Symposium
December 1-3, 2010
Berlin, Germany

Tissue Engineering & Regenerative Medicine International Society – North America (TERMIS-NA) 2010 Annual Conference
December 5-8, 2010
Orlando, United States

The American Society for Cell Biology 50th Annual Meeting
December 11-15, 2010
Philadelphia, United States

Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

NEW Extracellular Matrix and Cardiovascular Remodeling
January 23-28, 2011
Tahoe City, United States

Select Biosciences 5th Annual Stem Cells World Congress
January 24-25, 2011
San Diego, United States

NEW BIO Asia International Partnering Conference
January 24-25, 2011
Tokyo, Japan

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, DC, United States

NEW Molecular Medicine Tri-Conference – Stem Cells: Revolutionizing Regenerative Medicine and Personalized Therapy 2011
February 23-25, 2011
San Francisco, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.




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