Volume 11.25 | Jul 2

ECM 11.25 | Jul 2
Extracellular Matrix News by STEMCELL Technologies
Vol. 11.25 – 2 July, 2020

A Tissue-Engineered Uterus Supports Live Births in Rabbits

Scientists used biodegradable polymer scaffolds seeded with autologous cells to restore uterine structure and function in rabbits. Rabbits underwent a subtotal uterine excision and were reconstructed with autologous cell-seeded constructs, with nonseeded scaffolds or by suturing.
[Nature Biotechnology]


PUBLICATIONSRanked by the impact factor of the journal

Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis

The authors showed that tumor vascular function as well as pericyte coverage was significantly impaired in mice with conditional knockout of platelet-derived growth factor (PDGFB) in platelets.
[Cancer Research]


Control of Fibroblast Shape in Sequentially Formed 3D Hybrid Hydrogels Regulates Cellular Responses to Microenvironmental Cues

Investigators presented a hydrogel-based platform to control cell shape in three dimensions by using sequentially formed hybrid hydrogels consisting of collagen and alginate.
[NPG Asia Materials]

Full Article

Driver Mutations in Leukemia Promote Disease Pathogenesis through a Combination of Cell-Autonomous and Niche Modulation

Researchers showed that constitutive and early loss of the epigenetic regulator, TET2, when combined with constitutive activation of FLT3, results in transformation of chronic myelomonocytic leukemia-like or myeloproliferative neoplasm-like phenotype to acute myeloid leukemia, which is more pronounced in double-mutant mice relative to mice carrying mutations in single genes.
[Stem Cell Reports]

Full Article

EGFR/Ras-Induced CCL20 Production Modulates the Tumor Microenvironment

The effects of CCL20 on endothelial cell migration and tumor-associated vascularization were comprehensively analyzed with chemotaxis assays in vitro and in CCR6-deficient mice in vivo.
[British Journal of Cancer]


HSPG2 Overexpression Independently Predicts Poor Survival in Patients with Acute Myeloid Leukemia

The mRNA expression level of heparan sulfate proteoglycan 2 (HSPG2) in bone marrow mononuclear cells and CD34+ hematopoietic stem/progenitor cells obtained from enrolled participants and human leukemic cell lines was detected by RT-qPCR.
[Cell Death & Disease]

Full Article

Switch of Macrophage Fusion Competency by 3D Matrices

Scientists introduced a collagen-based 3D matrix to embed Raw264.7 cell line and primary rat bone marrow-derived macrophages.
[Scientific Reports]

Full Article

Pre-Innervated Tissue-Engineered Muscle Promotes a Pro-Regenerative Microenvironment following Volumetric Muscle Loss

Investigators developed pre-innervated tissue-engineered muscle comprised of long aligned networks of spinal motor neurons and skeletal myocytes on aligned nanofibrous scaffolds.
[Communications Biology]

Full Article


The Control of Conjunctival Fibrosis as a Paradigm for the Prevention of Ocular Fibrosis-Related Blindness. “Fibrosis Has Many Friends”

Scientists provide current and futures perspectives on different approaches to conjunctival fibrosis following glaucoma surgery and highlights the challenges faced in implementing these therapies with maximal effect and minimal side effects.



AiViva Biopharma Announces Positive Data from Phase I/IIa Clinical Trial of AIV001 for Dermal Scarring and Wound Healing

AiViva Biopharma Inc., has announced completion of its first Phase I/IIa study evaluating AIV001 in dermal scarring. A total of 16 subjects who were scheduled to undergo abdominoplasty were enrolled and completed in one of the four double-blind dose escalation or open label cohorts.
[AiViva BioPharma]

Press Release

United Kingdom Plans ‘Office for Talent’ to Smooth Entry for Top Scientists

The UK government plans to set up an “office for talent” to oversee visas and make it easier to attract top scientists after Brexit, according to an R&D road map.


Hong Kong Universities Rattled by New Security Law

Academics in Hong Kong are facing new worries after the mainland government abruptly imposed a controversial new security law that critics say could infringe on human rights and chill academic freedom.


Amidst Uncertainty, Flexibility Is Key in Higher Ed, Faculty Say

Life sciences professors and other staff make contingency plans for more coronavirus-related disruptions in the coming school year.
[The Scientist]



Micro-CT: Fancy Gadget or Indispensable Technology towards Accurate Quantification of Lung Disease and Therapy?

July 9

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Postdoctoral Position – Extracellular Matrix Integrins

Max Planck Institute for Medical Research – Heidelberg, Germany

Postdoctoral Fellow Position – Primitive Collagen and Stem Cell Chondrogenesis

Drexel University – Philadelphia, Pennsylvania, United States

Postdoctoral Associate – Optic Nerve Head Extracellular Matrix Remodeling

University of Pittsburgh – Pittsburgh, Pennsylvania, United States

Department Chair – Bioengineering

The University of Washington – Seattle, Washington, United States

Senior Scientist – Developmental and Regenerative Biology

Icahn School of Medicine at Mount Sinai – New York City, New York, United States

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